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Protein Overview: Sas-4-PA

General Information:
Name(s) found: Sas-4-PA / FBpp0081088 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Sas-4 is referred to in FlyBase by the symbol Dmel\Sas-4 (CG10061, FBgn0011020). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:2977076..2979886. It has the cytological map location 84C6-84C7. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: centrosome organization; cilium assembly; locomotion; flagellum assembly; mitotic spindle organization; centriole replication; centrosome duplication; asymmetric cell division. 9 alleles are reported. The phenotypes of these alleles are annotated with: centriole; neuroblast; flagellum; centrosome; cilium. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 901 amino acids

    Gene Ontology:
    Cellular Component: centriole [IDA]
    Biological Process: centrosome organization [IMP]
    locomotion [IMP]
    centriole replication [IMP]
    centrosome duplication [IMP]
    mitotic spindle organization [IMP]
    cilium assembly [IMP]
    flagellum assembly [IMP]
    asymmetric cell division [IMP]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQEAGESPVG MPLSQEAIAQ RLAALSRWQD EQKRLLQERQ SNHRVLLGLE QRNMYKMLGL  60
   61 LHQETESHEN SVLEEWDEEH SIQMPRLAAD PDEHEPEISM ADPQPAKPKR PFLRRGEGLK 120
  121 QRFKINPDQL RLENLPRYKF ANAHPQFRTP QMKKGILKKQ VKSPPNPAPP PAPKPSAQLD 180
  181 DLNEQRFQQM LIGKNACSST PDLKSSYASS TTASSTSPRV RFVEQKSRAG QTTHADDEAS 240
  241 SEASPMTGVC WAKVLDTQSI KPAQIQRRSA QIRVEDDSNV SIFELLEQKA TEGNIDMNSS 300
  301 CIRTFMARKD QRRRVADDSD HIVVTQQVRQ MRLQPQVDQM LVQELQEGDE EDTEPSSDQT 360
  361 LTMTPIQVGN TKVRVRFSDS NDTHEYSDAT SLNDGSNIQL FEQFKSALFQ ALEQKKKSSP 420
  421 SKESDEPITK DLQEKANLVR TRLEELETEI ATFKEQNAQL LRLRQQHELE KAKCTQDHME 480
  481 AMERVHDEKI QAEIYLHDER MKIEEERRKF EQQMRLQKSN ANSKEKKEIA ALKQEVEGLQ 540
  541 LQLKQKEQAH VSAQARLRAQ LRASEKEQRN YRDEIELLRK ENKRLEQELV KIGRENNSKM 600
  601 LQEINRNIAR LAPKVLPSAT MSDILDENGR RTQSLDGTAG KPAKQREAQN RRQSSGSAQV 660
  661 RSRSRSLSRN KKTPYALDES YASSSSVESE EVQPPVTAPK AATPPPAANS SSDFKREITN 720
  721 ADGSKDIWYP NGNLKKISAD GMNLRMLYFN KDIKETNIRE GTVKYYYAET NTWHTSYLDG 780
  781 LEILEFPNGQ TEHRRKDGTV EIHFPNNSIK IVDPSDTEKL EEWRYADGTH LVQLRNGDKI 840
  841 LNLPNGQKEI HTKLNKRREY PDGTVKLVYP DGSQETRYSN GRVRLKDKDG KLIMDTDYAK 900
  901 Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..329] PSI-BLAST 22.69897 Heavy meromyosin subfragment
    2 View Details [330..609] PSI-BLAST 10.69897 Tropomyosin
    3 View Details [610..811] PSI-BLAST 3.522879 No description for 2iw5A was found.
    4 View Details [812..901] Pfam 21.744727 No description for PF07202.4 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.45058468282438 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.1457670954804 bayes_pls_golite062009
  • actin binding
    		•  1.48871115327078 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.38505016881116 bayes_pls_golite062009
  • DNA binding
    		•  1.29464499177454 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.27419374347122 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.13700925407906 bayes_pls_golite062009
  • protein binding
    		•  1.03780839342631 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.88156363379437 bayes_pls_golite062009
  • transcription factor activity
    		•  0.694399096428821 bayes_pls_golite062009
  • actin filament binding
    		•  0.26311995282891 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle