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View Structure Prediction Details

Protein: Sas-4-PA
Organism: Drosophila melanogaster
Length: 901 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Sas-4-PA.

Description E-value Query
Range
Subject
Range
gi|68388302 - gi|68388302|ref|XP_696268.1| PREDICTED: similar to slow myosin heavy chain 1 [Danio rerio]
363.0 [0..4] [875..1839]

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Predicted Domain #1
Region A:
Residues: [1-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQEAGESPVG MPLSQEAIAQ RLAALSRWQD EQKRLLQERQ SNHRVLLGLE QRNMYKMLGL  60
   61 LHQETESHEN SVLEEWDEEH SIQMPRLAAD PDEHEPEISM ADPQPAKPKR PFLRRGEGLK 120
  121 QRFKINPDQL RLENLPRYKF ANAHPQFRTP QMKKGILKKQ VKSPPNPAPP PAPKPSAQLD 180
  181 DLNEQRFQQM LIGKNACSST PDLKSSYASS TTASSTSPRV RFVEQKSRAG QTTHADDEAS 240
  241 SEASPMTGVC WAKVLDTQSI KPAQIQRRSA QIRVEDDSNV SIFELLEQKA TEGNIDMNSS 300
  301 CIRTFMARKD QRRRVADDSD HIVVTQQVR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.69897
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [330-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QMRLQPQVDQ MLVQELQEGD EEDTEPSSDQ TLTMTPIQVG NTKVRVRFSD SNDTHEYSDA  60
   61 TSLNDGSNIQ LFEQFKSALF QALEQKKKSS PSKESDEPIT KDLQEKANLV RTRLEELETE 120
  121 IATFKEQNAQ LLRLRQQHEL EKAKCTQDHM EAMERVHDEK IQAEIYLHDE RMKIEEERRK 180
  181 FEQQMRLQKS NANSKEKKEI AALKQEVEGL QLQLKQKEQA HVSAQARLRA QLRASEKEQR 240
  241 NYRDEIELLR KENKRLEQEL VKIGRENNSK MLQEINRNIA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 2tmaA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [610-811]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLAPKVLPSA TMSDILDENG RRTQSLDGTA GKPAKQREAQ NRRQSSGSAQ VRSRSRSLSR  60
   61 NKKTPYALDE SYASSSSVES EEVQPPVTAP KAATPPPAAN SSSDFKREIT NADGSKDIWY 120
  121 PNGNLKKISA DGMNLRMLYF NKDIKETNIR EGTVKYYYAE TNTWHTSYLD GLEILEFPNG 180
  181 QTEHRRKDGT VEIHFPNNSI KI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 2iw5A
Description: No description for 2iw5A was found.

Predicted functions:

Term Confidence Notes
binding 2.45058468282438 bayes_pls_golite062009
cytoskeletal protein binding 2.1457670954804 bayes_pls_golite062009
actin binding 1.48871115327078 bayes_pls_golite062009
transcription regulator activity 1.38505016881116 bayes_pls_golite062009
DNA binding 1.29464499177454 bayes_pls_golite062009
nucleic acid binding 1.27419374347122 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.13700925407906 bayes_pls_golite062009
protein binding 1.03780839342631 bayes_pls_golite062009
sequence-specific DNA binding 0.88156363379437 bayes_pls_golite062009
transcription factor activity 0.694399096428821 bayes_pls_golite062009
actin filament binding 0.26311995282891 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [812-901]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDPSDTEKLE EWRYADGTHL VQLRNGDKIL NLPNGQKEIH TKLNKRREYP DGTVKLVYPD  60
   61 GSQETRYSNG RVRLKDKDGK LIMDTDYAKY 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 21.744727
Match: PF07202.4
Description: No description for PF07202.4 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle