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Protein Overview: sol-PB

General Information:
Name(s) found: sol-PB / FBpp0088620 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene small optic lobes is referred to in FlyBase by the symbol Dmel\sol (CG1391, FBgn0003464). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:21221357..21228939. It has the cytological map location 19F5. Based on sequence similarity, it is predicted to have molecular function</span>: calcium-dependent cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: nervous system development. 21 alleles are reported. The phenotypes of these alleles are annotated with: medulla neuropil; larval optic stalk; central nervous system; lobula plate cortex; optic lobe; lobula; adult central nervous system; lobula plate neuropil; medulla cortex; pigment-dispersing hormone-immunoreactive neuron. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1594 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    intracellular [IEA]
    Biological Process: proteolysis [IEA]
    nervous system development [IMP]
    visual behavior [NAS]
    Molecular Function: zinc ion binding [IEA]
    calcium-dependent cysteine-type endopeptidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTISSVLQW SCTKCNTINP TESLKCFNCG TVRKVFPQQQ QQQHRSSSIT ASWTADDALE  60
   61 QEQAEKGQER DKEKGRAAVA RSEYKHVYKS LLRGCLKRPQ RNSQNLPANC VDCEDTRKYI 120
  121 KSSIELYRHF SNPALNRRWV CHACGTDNSS VTWHCLICDT VSYLAPIYKD AIAADRGQDL 180
  181 AGSLGNRGEL LAADHSHPHH HHHYLHQELE EQHQHQLHSQ HLHKRHLKGR SASGSGSGPG 240
  241 SGSGLRRTQS LSTAIDKSAS GRSCHICYAN NQSKDIFNLP QIKPAPQLTG IPPVAACSNS 300
  301 RFAIANDTFC RRKQNNNNKN QNHKVVRESG AKRKYNFTIT TLSRSAAKDA GHGQMKPLRQ 360
  361 VVNLNLNLQQ EPQQKSPANP QQLQRKTQRE PAAVSMNPTQ FTIPRNGVFI AVNEWSEPMA 420
  421 SSSSVSSSSN HHHHHHSNSN SNSSGNSNII NNNSSSSSGS NKLYENECVA LAQQQLRAAA 480
  481 AQAAQAAATA VAIASSPSAK AMAEPAPTAT MPIYAQVNKQ HKLKKKQQIA SESQTNNNTG 540
  541 SGEIADAVSE SLTAGLGTST DGSGEASESE SQVEEHSIYA KVWKGPRKAT ESKIMHDPGS 600
  601 SSRLSGAASA AAGTASAGAI AAAVGAAAAS RHDNKTQLGN GSRSKMWICI KCSYAYNRLW 660
  661 LQTCEMCEAK AEQQQQQLQL QQQQQQQQQH HHHHLQQQQA EAPRDEPWTC KKCTLVNYST 720
  721 AMACVVCGGS KLKSISSIED MTLRKGEFWT CSHCTLKNSL HSPVCSACKS HRQPQLSMAM 780
  781 EAVRERPDGQ SYEEQDAAAV GGGGGSAHQS GANEVKAPTA LNLPLTSVAL PMPMLQLPTS 840
  841 TAAGLRGSRS PSPRMQLLPS LQQQRNSSSS GAIPKRHSTG GSIVPRNISI AGLANYNLQQ 900
  901 GQGVGSASVV SASGAGSGAG AVGASTSTKK WQCPACTYDN CAASVVCDIC SSPRGLASAV 960
  961 LGEALGRKSV RVALTPADIR QESKLMENLR QLEETEALTK WQNIIQYCRD NSELFVDDSF1020
 1021 PPAPKSLYYN PASGAGEGNP VVQWRRPHEI NCDGGAYPPW AVFRTPLPSD ICQGVLGNCW1080
 1081 LLSALAVLAE REDLVKEVLV TKEICGQGAY QVRLCKDGKW TTVLVDDLLP CDKRGHLVYS1140
 1141 QAKRKQLWVP LIEKAVAKIH GCYEALVSGR AIEGLATLTG APCESIPLQA SSLPMPSEDE1200
 1201 LDKDLIWAQL LSSRCVRFLM GASCGGGNMK VDEEEYQQKG LRPRHAYSVL DVKDIQGHRL1260
 1261 LKLRNPWGHY SWRGDWSDDS SLWTDDLRDA LMPHGASEGV FWISFEDVLN YFDCIDICKV1320
 1321 RSGWNEVRLQ GTLQPLCSIS CVLLTVLEPT EAEFTLFQEG QRNSEKSQRS QLDLCVVIFR1380
 1381 TRSPAAPEIG RLVEHSKRQV RGFVGCHKML ERDIYLLVCL AFNHWHTGIE DPHQYPQCIL1440
 1441 AIHSSKRLLV EQISPSPHLL ADAIISLTLT KGQRHEGREG MTAYYLTKGW AGLVVMVENR1500
 1501 HENKWIHVKC DCQESYNVVS TRGELKTVDS VPPLQRQVII VLTQLEGSGG FSIAHRLTHR1560
 1561 LANSRGLHDW GPPGATHCPP IENVHGLHAP RLIT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..230] deduced N/A No confident structure predictions are available.
    2 View Details [231..423] MSA 3.281993 View MSA. No confident structure predictions are available.
    3 View Details [424..550] MSA 3.293989 View MSA. No confident structure predictions are available.
    4 View Details [551..672] deduced N/A No confident structure predictions are available.
    5 View Details [673..993] PSI-BLAST 3.69897 Receptor protein-tyrosine kinase Erbb-3 extracellular domain; Receptor protein-tyrosine kinase Erbb-3 Cys-rich domains
    6 View Details [994..1594] PSI-BLAST 1000.0 Crystal Structure of a mu-like calpain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein binding
    		•  0.896934807256194 bayes_pls_golite062009
  • binding
    		•  0.843808199409152 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.692376479375244 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.03276746586736 bayes_pls_golite062009
  • protein binding
    		•  2.01842861979642 bayes_pls_golite062009
  • growth factor binding
    		•  1.94941983865103 bayes_pls_golite062009
  • insulin-like growth factor binding
    		•  1.16573145970749 bayes_pls_golite062009
    6
    Term Confidence Notes
  • protein binding
    		•  0.896934807256194 bayes_pls_golite062009
  • binding
    		•  0.843808199409152 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.692376479375244 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle