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View Structure Prediction Details

Protein: sol-PB
Organism: Drosophila melanogaster
Length: 1594 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sol-PB.

Description E-value Query
Range
Subject
Range
gi|21711741 - gi|21711741|gb|AAM75061.1| RE21811p [Drosophila melanogaster]
1080.0 [0..1] [1594..1]

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Predicted Domain #1
Region A:
Residues: [1-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTISSVLQW SCTKCNTINP TESLKCFNCG TVRKVFPQQQ QQQHRSSSIT ASWTADDALE  60
   61 QEQAEKGQER DKEKGRAAVA RSEYKHVYKS LLRGCLKRPQ RNSQNLPANC VDCEDTRKYI 120
  121 KSSIELYRHF SNPALNRRWV CHACGTDNSS VTWHCLICDT VSYLAPIYKD AIAADRGQDL 180
  181 AGSLGNRGEL LAADHSHPHH HHHYLHQELE EQHQHQLHSQ HLHKRHLKGR 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [231-423]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASGSGSGPG SGSGLRRTQS LSTAIDKSAS GRSCHICYAN NQSKDIFNLP QIKPAPQLTG  60
   61 IPPVAACSNS RFAIANDTFC RRKQNNNNKN QNHKVVRESG AKRKYNFTIT TLSRSAAKDA 120
  121 GHGQMKPLRQ VVNLNLNLQQ EPQQKSPANP QQLQRKTQRE PAAVSMNPTQ FTIPRNGVFI 180
  181 AVNEWSEPMA SSS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein binding 0.896934807256194 bayes_pls_golite062009
binding 0.843808199409152 bayes_pls_golite062009
cysteine-type peptidase activity 0.692376479375244 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [424-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVSSSSNHHH HHHSNSNSNS SGNSNIINNN SSSSSGSNKL YENECVALAQ QQLRAAAAQA  60
   61 AQAAATAVAI ASSPSAKAMA EPAPTATMPI YAQVNKQHKL KKKQQIASES QTNNNTGSGE 120
  121 IADAVSE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [551-672]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLTAGLGTST DGSGEASESE SQVEEHSIYA KVWKGPRKAT ESKIMHDPGS SSRLSGAASA  60
   61 AAGTASAGAI AAAVGAAAAS RHDNKTQLGN GSRSKMWICI KCSYAYNRLW LQTCEMCEAK 120
  121 AE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [673-993]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQQQLQLQQ QQQQQQQHHH HHLQQQQAEA PRDEPWTCKK CTLVNYSTAM ACVVCGGSKL  60
   61 KSISSIEDMT LRKGEFWTCS HCTLKNSLHS PVCSACKSHR QPQLSMAMEA VRERPDGQSY 120
  121 EEQDAAAVGG GGGSAHQSGA NEVKAPTALN LPLTSVALPM PMLQLPTSTA AGLRGSRSPS 180
  181 PRMQLLPSLQ QQRNSSSSGA IPKRHSTGGS IVPRNISIAG LANYNLQQGQ GVGSASVVSA 240
  241 SGAGSGAGAV GASTSTKKWQ CPACTYDNCA ASVVCDICSS PRGLASAVLG EALGRKSVRV 300
  301 ALTPADIRQE SKLMENLRQL E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1m6bA
Description: Receptor protein-tyrosine kinase Erbb-3 extracellular domain; Receptor protein-tyrosine kinase Erbb-3 Cys-rich domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.03276746586736 bayes_pls_golite062009
protein binding 2.01842861979642 bayes_pls_golite062009
growth factor binding 1.94941983865103 bayes_pls_golite062009
insulin-like growth factor binding 1.16573145970749 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [994-1594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETEALTKWQN IIQYCRDNSE LFVDDSFPPA PKSLYYNPAS GAGEGNPVVQ WRRPHEINCD  60
   61 GGAYPPWAVF RTPLPSDICQ GVLGNCWLLS ALAVLAERED LVKEVLVTKE ICGQGAYQVR 120
  121 LCKDGKWTTV LVDDLLPCDK RGHLVYSQAK RKQLWVPLIE KAVAKIHGCY EALVSGRAIE 180
  181 GLATLTGAPC ESIPLQASSL PMPSEDELDK DLIWAQLLSS RCVRFLMGAS CGGGNMKVDE 240
  241 EEYQQKGLRP RHAYSVLDVK DIQGHRLLKL RNPWGHYSWR GDWSDDSSLW TDDLRDALMP 300
  301 HGASEGVFWI SFEDVLNYFD CIDICKVRSG WNEVRLQGTL QPLCSISCVL LTVLEPTEAE 360
  361 FTLFQEGQRN SEKSQRSQLD LCVVIFRTRS PAAPEIGRLV EHSKRQVRGF VGCHKMLERD 420
  421 IYLLVCLAFN HWHTGIEDPH QYPQCILAIH SSKRLLVEQI SPSPHLLADA IISLTLTKGQ 480
  481 RHEGREGMTA YYLTKGWAGL VVMVENRHEN KWIHVKCDCQ ESYNVVSTRG ELKTVDSVPP 540
  541 LQRQVIIVLT QLEGSGGFSI AHRLTHRLAN SRGLHDWGPP GATHCPPIEN VHGLHAPRLI 600
  601 T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1qxpA
Description: Crystal Structure of a mu-like calpain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 0.896934807256194 bayes_pls_golite062009
binding 0.843808199409152 bayes_pls_golite062009
cysteine-type peptidase activity 0.692376479375244 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle