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Protein Overview: FBpp0300625, cngl-PC

General Information:
Name(s) found: FBpp0300625 [FlyBase]
cngl-PC / FBpp0088348 [FlyBase]
Description(s) found:
Found 13 descriptions.
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  • type=protein; loc=X:complement(15285743..15285762,15286403..15287034,15287095..15288488,15289018..15289224,15290432..15290651,15290747..15291088,15291208..15291608,15291677..15291830,15292491..15292621,15292774..15292926,15292989..15293129,15293246..15293353,15294301..15294504,15294712..15294847,15297617..15297735); ID=FBpp0300625; name=cngl-PC; parent=FBgn0263257,FBtr0308306; dbxref=FlyBase_Annotation_IDs:CG43395-PC,FlyBase:FBpp0300625,FlyBase:FBpp0088348,FlyBase_Annotation_IDs:CG9176-PC; MD5=68e680d43fb25a22e008a799577926e5; length=1453; release=r5.43; species=Dmel; [FlyBase]
  • The gene CNG channel-like is referred to in FlyBase by the symbol Dmel\cngl (CG9176, FBgn0029090). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15283639..15298498. It has the cytological map location 13C1. Based on sequence similarity, it is predicted to have molecular function</span>: intracellular cyclic nucleotide activated cation channel activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: transmembrane transport; ion transport. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1453 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Biological Process: ion transport [IEA]
    transmembrane transport [IEA]
    Molecular Function: intracellular cyclic nucleotide activated cation channel activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRNKSTKET ARNKKKMKYF RNSFRKSRIG DGASDPDSDW TRSNQRWMKL RTTVQISSAI  60
   61 QKKPPLKRED SFLKRFSTRQ IPETQETVED TGSESASGDV DKSVKRRRRY LQKRRSVVNP 120
  121 DENFYFYWLM MLTVCVLYNL WTLIVRQSFP ELQQSVPTFW LICDSMTDVV FILDIIVQLR 180
  181 TGYLEQGLMV YDDRKLACHY VHSRDFIFDM IALIPLDLLQ LKMGTHPLLR FTRFFKVYRS 240
  241 VRFYYIVESR TVWPNLWRVV NLIHILLILA HWFGCFYFLL SEAEGFQGDW VYPYRPGDYA 300
  301 TLTRKYLGSL YWSTLTLTTI GDLPTPETNA EYIFTIVSYL IGVFIFATIV GQVGNVITNR 360
  361 NANRLEFERL LDGAKTYMRH HKVPGGMKRR VLRWYDYSWS RGRIQGGGDI NTALGLLPDK 420
  421 LKTELALHVN LSVLKKVTIF QECQPEFLHD LVLKMKAYIF TPGDSICRKG EVAREMFIIA 480
  481 DGILEVLSET GKVLTTMKAG DFFGEIGILN LDGLNKRTAD VRSVGYSELF SLSREDVLAA 540
  541 MKDYPDAQEI LQTLGRKRLM EVRCVNKKYA KAQSDKEAAA YAAAHPHHHQ SHHQGQVHQS 600
  601 DSSENSASKK IVDKLKHDVK GFRNVLKKSR TSRKSDESLE MQPLHNTSPR GSKILLKRMS 660
  661 RVRSDEKDAD SAEAKDELHD KTPSPIGAGL PLLQRLRLLK EKQDREERAV KSTPPQKSPP 720
  721 HSHVTCTLSP QESIQEEPER EFSEGFPLIQ RLQQLKIKNE PQANAAEPGV VMVNTPPNIS 780
  781 SKIDSHFAAS QAGASHPGPN GGAIGISAPG QSLTVAQIKP IMKVSFKQKI QQMQGGGGGA 840
  841 SSSPGPSTGA IAKKEPPKSL ALVAKHATSE DPVAAAGLGL GSGSSSGIAT ISKRVVKPQS 900
  901 HRMATPLQSD TDTDGTPIKP WSKLKLATLM SSSYTSLTNC SPDDLASPLK NYSLSNIPQQ 960
  961 MESHTRPRHH SARSSSRSPR HGHHHHHHHG HHQHGQLQGP SSTCTNGSTT SQVNQVTASA1020
 1021 KRDCLRLQKP EQHLPDGELT ELGGNGRRKL YQSVFDLSPE YCGLPFVKRL KILNERQKLA1080
 1081 ELERALQTRS FSLDCSKSGP DSKVPITESL YRCYSDTSGI YSQFLSTYES TTSSTSISTN1140
 1141 TSASASASAS ASASASDSNS RQLQYVPLPL SPESNETMER RKLKSILKKL QMGGGQQEEA1200
 1201 GPGTGTGAGA VMGTGSKVNS SASQKGQGLP AEPTLEGPPA SAKEEESPFG GAAAIGSVNN1260
 1261 ACGNGNGNGS VSGNGNGSGT VNDSSANSSS HPSNNGNSAY TCPPPPSVAF PFPVPIAPAS1320
 1321 GSVPLPLEPG VSNVWSPTLT LVTPTNSPQE SFAFPAQLQG ELGGHGTGRG LVGGVGSASA1380
 1381 SMLPAGAGAS ASASASTSTS ASYVVECSAS SNQILHAQST TDLNLNLQLR QNTTSSMGGP1440
 1441 GPAQRIEGFY RNI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..511] PSI-BLAST 3.522879 No description for 2nyyA was found.
    2 View Details [512..631] PSI-BLAST 39.0 HCN2J 443-645 in the presence of cGMP
    3 View Details [632..839] deduced N/A No confident structure predictions are available.
    4 View Details [840..975] deduced N/A No confident structure predictions are available.
    5 View Details [976..1453] PSI-BLAST 18.045757 No description for 1y0fB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.56259855231916 bayes_pls_golite062009
  • carbohydrate binding
    		•  1.40439904952516 bayes_pls_golite062009
  • sugar binding
    		•  1.06597588006145 bayes_pls_golite062009
  • amine binding
    		•  0.947632395806172 bayes_pls_golite062009
  • protein binding
    		•  0.657665757061848 bayes_pls_golite062009
  • signal transducer activity
    		•  0.631926547812897 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.631926547812897 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.5678336426881 bayes_pls_golite062009
  • receptor activity
    		•  0.23954333371021 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00800219256384116 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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