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Protein Overview: dwg-PA

General Information:
Name(s) found: dwg-PA / FBpp0070465 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene deformed wings is referred to in FlyBase by the symbol Dmel\dwg (CG2711, FBgn0000520). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2621733..2624092. It has the cytological map location 3B3. There is experimental evidence that it has the molecular function</span>: protein binding; chromatin insulator sequence binding. The biological processes in which it is involved are not known. 49 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: peripheral nervous system; nervous system; organ system; external compound sense organ; adult segment; sensillum; adult mesothoracic segment; integumentary plate; anterior orbital bristle; anterior vertical bristle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 592 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    nuclear chromatin [IDA]
    Biological Process: NONE FOUND
    Molecular Function: transcription factor activity [ISS]
    zinc ion binding [IEA]
    protein binding [IPI]
    chromatin insulator sequence binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMNSKIAEVV VLNCRTCTRA CKLHKPLQEE IDLGSEGSTT LASMLNYCTG LSFEPQDGAA  60
   61 MPQHICLHCL QLLEQAFNFK RMVIDSDELL RLGLDEARCS SFHESQTHSP NQSQQHDQQQ 120
  121 QAFDSTEEYV MIEMLNEEQE NVANLDEELA EEDRRIFAMT VDEEEEFLTE EVDQDDELSE 180
  181 EEHQLAQSGD QQEEHITMES VHEFQPAEVE YVTIKNEFET IVTEEDEFEV MNDSGAHDAI 240
  241 LDCQMIVIPA EGAIDEVIGE ETLELEGDGR EEHLLPEAED VCEDEDFLEE SLDSAPPTAG 300
  301 EALPYVCTVC QKAFRQQCRL NQHMRSHVDE KQYECEECGK RLKHLRNYKE HMLTHTNVKP 360
  361 HQCSICGRFY RTTSSLAVHK RTHAEKKPYN CDQCGRGYAA FDHLRRHKLT HTGERPYACD 420
  421 LCDKAYYDSS SLRQHKISHT GKKAFTCEIC GVGLSQKSGY KKHMMVHSGV KAHKCDVCGH 480
  481 AFTFTSNLNA HVRLHSGEKP FKCEVCVKAF PTKKRLASHM RVHNKESPVT ATVAVQSINP 540
  541 PSRQAGAEGA TGGGATGGSP TGGGATGGSA TNLHITEVHE QPVSTSKVVM VL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] PSI-BLAST 7.0 Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone
    2 View Details [94..157] PSI-BLAST 10.522879 Solution structure of the Kruppel-associated box (KRAB) domain
    3 View Details [158..364] FFAS03 7.6 No description for 2i13A was found.
    4 View Details [365..592] PSI-BLAST 66.69897 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.88834375049208 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.62841402245495 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62405765585032 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.46067968492906 bayes_pls_golite062009
  • protein binding
    		•  1.39455913713025 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.14370842685155 bayes_pls_golite062009
  • structural molecule activity
    		•  1.03433454627943 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    2
    Term Confidence Notes
  • nucleic acid binding
    		•  2.36376512665406 bayes_pls_golite062009
  • DNA binding
    		•  2.2458683155586 bayes_pls_golite062009
  • binding
    		•  2.05464920186799 bayes_pls_golite062009
  • protein binding
    		•  0.476896736636797 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle