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Protein Overview: brk-PA

General Information:
Name(s) found: brk-PA / FBpp0071007 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene brinker is referred to in FlyBase by the symbol Dmel\brk (CG9653, FBgn0024250). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:7201974..7205645. It has the cytological map location 7B1. There is experimental evidence that it has the molecular function</span>: specific transcriptional repressor activity. There is experimental evidence that it is involved in the biological process</span>: wing disc morphogenesis; cell competition in a multicellular organism; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; imaginal disc-derived wing morphogenesis. 65 alleles are reported. The phenotypes of these alleles are annotated with 36 unique terms, many of which group under: organ system; primordium; adult segment; embryonic nervous system; adult mesothoracic segment; ventral nerve cord primordium; portion of tissue; peripheral nervous system; thoracic segment; imaginal precursor. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 704 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMP][TAS]
    cell competition in a multicellular organism [IMP]
    wing disc morphogenesis [IMP]
    transforming growth factor beta receptor signaling pathway [TAS]
    salivary gland boundary specification [NAS]
    nervous system development [NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    regulation of BMP signaling pathway [TAS]
    negative regulation of transforming growth factor beta receptor signaling pathway [IMP][NAS]
    Molecular Function: transcription factor activity [ISS]
    RNA polymerase II transcription factor activity [NAS]
    transcription repressor activity [TAS]
    specific transcriptional repressor activity [IMP][NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSSSEQLNG SGALNFKRPK DSSENATNSH TNNGNSSGSP KMGSRRIFTP HFKLQVLESY  60
   61 RNDNDCKGNQ RATARKYNIH RRQIQKWLQC ESNLRSSVAN NQQQQQQQQQ QQQQQQQQQQ 120
  121 LLPQQSVSPT PAVKVFHQLS HPLVHQLHHH HAAAVGHHHH HAAHHHAAHH HHAAAAAAAA 180
  181 AAAAAAAAAH HHAAHHLLAA NGMVPHPLAA HPHLHVPVAM HPQMQHQKEQ QQQQQQLQQE 240
  241 QQQQDQQQSQ QETPATIATN GSNQGSSNVL SAAKIAAVVA AAMATSNGNP TPTATIPASS 300
  301 SSSSNTLPSS NNSSCHNSSS SSNSCNSNQV PIQVPILSGS PGSTSSASHI PHVPFAYHHN 360
  361 LHGYLENRLE AVATPAPMDL SLGSSARRQM QLHEKDPSGV DLTFRKRKVI TSPMQPDKIS 420
  421 KLEEVIKKEP ETETENEDVE VDVETEQPEE HKLPSKQVKL FKPYLLDDDE EQDHHHHHHH 480
  481 HRQEDLDEGA AEEEQDDEEE SRYADDDEVD SKEAADKKQR RLKKKPSAIN EQREPIIWSN 540
  541 HPYPGGCVSP GSSITSSFQC PTSMQQQQTF PVAGGSPNQQ FQDNCSSSKA TTPLSPFSAP 600
  601 ALSPTGFCCP KGSPVSGYES SSSTYSDSGS NYSLNLQLHA VYNDNLMYMQ QQQQQQQQQH 660
  661 HLQHQQHLQR WLDQESLATA RTSSVNRPLI LVADTAPTNL TLVA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] FFAS03 6.06 No description for 2gloA was found.
    2 View Details [86..301] PSI-BLAST 8.30103 Sec24
    3 View Details [302..463] deduced N/A No confident structure predictions are available.
    4 View Details [464..589] deduced N/A No confident structure predictions are available.
    5 View Details [590..704] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

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