YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SIAH1_RAT

General Information:
Name(s) found: SIAH1_RAT [Swiss-Prot]
Description(s) found:
SHOW ONLY BEST
  • gi|82880666|ref|NP_543181.2| seven in absentia 1A [Rattus norvegicus] [NCBI NR]
  • gi|56405458|gb|AAV87215.1| SIAH [Rattus norvegicus] [NCBI NR]
  • gi|46577139|sp|Q920M9.2|SIAH1_RAT RecName: Full=E3 ubiquitin-protein ligase SIAH1; AltName: Full=Seven in absentia homolog 1; Short=Siah-1; AltName: Full=Siah-1a [NCBI NR]
  • gi|19550383|gb|AAL91362.1|AF389476_1 SIAH-1A [Rattus norvegicus] [NCBI NR]
  • gi|149032636|gb|EDL87506.1| rCG44348, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|149032635|gb|EDL87505.1| rCG44348, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • (Q920M9) Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a) [Swiss-Prot]
  • E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus GN=Siah1 PE=1 SV=2 [Swiss-Prot]
  • seven in absentia 1A [Mus musculus]gi|28277394|gb|AAH46317.1| Seven in absentia 1A [Mus musculus]gi|19550383|gb|AAL91362.1| SIAH-1A [Rattus norvegicus]gi|46577139|sp|Q920M9|SIH1_RAT Ubiquitin ligase SIAH1 (Seven in absentia homolog 1) (Siah-1) (Siah-1a [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Ubiquitin ligase SIAH1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • seven in absentia 1A [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • E3 ubiquitin-protein ligase SIAH1 (Seven in absentia homolog 1) (Siah-1) (Siah-1a) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • SIAH [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • rCG44348, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • SIAH-1A [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Ubiquitin ligase SIAH1 (Seven in absentia homolog 1) (Siah-1) (Siah-1a) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Siah1a E3 ubiquitin-protein ligase SIAH1 [rat-ipi-250309-contam.fasta]
  • E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus GN=Siah1 [011711_HMR.fasta]
  • RCG44348, isoform CRA_a OS=Rattus norvegicus GN=Siah1a [011711_HMR.fasta]
  • RCG44348, isoform CRA_a OS=Rattus norvegicus GN=Siah1a PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
  • Isoform of Q920M9, E3 ubiquitin-protein ligase OS=Rattus norvegicus GN=Siah1 PE=2 SV=1 [RAT.fasta.20160308]
    • Organism: Rattus norvegicus
    Length: 282 amino acids

    Gene Ontology:
    Cellular Component: beta-catenin destruction complex [UNKNOWN][ISS]
    nucleus [IEA]
    early endosome [IDA]
    cytoplasm [IEA]
    synaptic vesicle [IDA]
    Biological Process: regulation of multicellular organism growth [UNKNOWN]
    proteasomal ubiquitin-dependent protein catabolic process [ISS]
    multicellular organismal development [IEA]
    spermatogenesis [UNKNOWN][IEA]
    protein catabolic process [UNKNOWN]
    apoptosis [IEA]
    male meiosis I [UNKNOWN]
    post-embryonic development [UNKNOWN]
    cell differentiation [IEA]
    cell cycle [IEA]
    protein ubiquitination during ubiquitin-dependent protein catabolic process [IDA][ISS]
    Molecular Function: ubiquitin-protein ligase activity [IDA][ISS]
    zinc ion binding [UNKNOWN][ISS]
    protein binding [UNKNOWN][IPI]
    protein C-terminus binding [UNKNOWN][IEA]
    metal ion binding [IEA]
    ligase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQTATALP TGTSKCPPSQ RVPALTGTTA SNNDLASLFE CPVCFDYVLP PILQCQSGHL  60
   61 VCSNCRPKLT CCPTCRGPLG SIRNLAMEKV ANSVLFPCKY ASSGCEITLP HTEKAEHEEL 120
  121 CEFRPYSCPC PGASCKWQGS LDAVMPHLMH QHKSITTLQG EDIVFLATDI NLPGAVDWVM 180
  181 MQSCFGFHFM LVLEKQEKYD GHQQFFAIVQ LIGTRKQAEN FAYRLELNGH RRRLTWEATP 240
  241 RSIHEGIATA IMNSDCLVFD TSIAQLFAEN GNLGINVTIS MC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] PSI-BLAST 10.0 No description for 2cklB was found.
    2 View Details [97..282] PSI-BLAST 57.0 Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle