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Protein Overview: gi|149063239, gi...

General Information:
Name(s) found: gi|157820385 [NCBI NR]
gi|149063239 [NCBI NR]
Description(s) found:
Found 8 descriptions.
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  • gi|157820385|ref|NP_001101804.1| nuclear receptor co-repressor 2 [Rattus norvegicus] [NCBI NR]
  • gi|149063239|gb|EDM13562.1| nuclear receptor co-repressor 2 (predicted), isoform CRA_a [Rattus norvegicus] [NCBI NR]
    • Organism: Rattus norvegicus
    Length: 2472 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    nuclear body [UNKNOWN]
    transcriptional repressor complex [UNKNOWN]
    histone deacetylase complex [UNKNOWN]
    [NOT]nucleolus [UNKNOWN]
    chromatin [IDA]
    cellular_component [ND]
    Biological Process: biological_process [ND]
    telencephalon development [UNKNOWN]
    cell proliferation in forebrain [UNKNOWN]
    negative regulation of fat cell differentiation [UNKNOWN]
    estrous cycle phase [IEP]
    regulation of transcription [IEA]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    white fat cell differentiation [UNKNOWN]
    heart morphogenesis [UNKNOWN]
    forebrain development [UNKNOWN]
    negative regulation of transcription, DNA-dependent [UNKNOWN]
    in utero embryonic development [UNKNOWN]
    negative regulation of transcription [UNKNOWN]
    glucose homeostasis [UNKNOWN]
    response to estradiol stimulus [IEP]
    response to organic nitrogen [IEP]
    negative regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    Molecular Function: DNA binding [UNKNOWN][IEA]
    protein binding [UNKNOWN][IPI]
    histone deacetylase binding [UNKNOWN]
    transcription corepressor activity [UNKNOWN]
    protein N-terminus binding [UNKNOWN]
    Notch binding [UNKNOWN]
    sequence-specific DNA binding [UNKNOWN]
    chromatin binding [UNKNOWN]
    receptor activity [IEA]
    transcription repressor activity [UNKNOWN]
    molecular_function [ND]
    specific transcriptional repressor activity [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSTQPVAQ TWRAAEPRYP PHGISYPVQI ARPHTDVGLL EYQHHPRDYT SHLSPGSIIQ  60
   61 PQRRRPSLLS EFQPGSERSQ ELHLRPESRT FLPELGKPDI EFTESKRPRL ELLPDTLLRP 120
  121 APLLATGQPS GSEDLTKDRS LAGKLEPVSP PSPPHADPEL ELTPSRLSKE ELIQNMDRVD 180
  181 REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA 240
  241 AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQRFCQ 300
  301 RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG 360
  361 LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMDDPM 420
  421 KVYKDRQVTN MWSEQERDTF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK 480
  481 SLVRRSYRRR GKSQQQQQQQ QQQQQQQMAR SSQEEKEEKE KEKEADKEEE KQDAENEKEE 540
  541 LSKEKTDDTS GEDNDEKEAV ASKGRKTANS QGRRKGRITR SMANEANHEE TATPQQSSEL 600
  601 ASMEMNESSR WTEEEMETAK KGLLEHGRNW SAIARMVGSK TVSQCKNFYF NYKKRQNLDE 660
  661 ILQQHKLKME KERNARRKKK KTPAAASEET AFPPAAEDEE MEASGASANE EELAEEAEAS 720
  721 QASGNEVPRV GECSGPAAVN NSSDTESVPS PRTEATKDAG PKPASTEALP AATQPPVPPP 780
  781 EEPATVPDEP CPAPDASGPP SPVASPPPAA PPAAVDKDEQ DQAATVPQTE DAKEQKSEAE 840
  841 ELVIDVGKTE EPEAPEEPPE SVKSDHKEET EEEPEDKAKG PEAIETVSEA PLKVEEAGSK 900
  901 AAVTKGSSSG ATQDSDSSAT CSADEVDEPE GGDKGRLLSP RPSLLTPAGD PRASTSPQKP 960
  961 LDLKQLKQRA AAIPPIVTKV HEPPREDTVP PKPAPPVPPP TQHLQPEGDV SQQSGGSPRG1020
 1021 KCRSPVPPAE KEAEKASFFP AFPAEGPKLP TEPPRWTSGL PFPIPPREVI KTSPHAADPS1080
 1081 AFSYTPPGHP LPLGLHDSAR PVLPRPPISN PPPLISSAKH PGVLERQLGT ISQQGMSVQL1140
 1141 RVPHSEHAKA PMGPLTMGLP LAVDPKKLGT ALGSTASGSI TKGLPSTRTA DGPSYRGSIT1200
 1201 HGTPADVLYK GTISRIVGED SPSRLDRARE DTLPKGHVIY EGKKGHVLSY EGGMSVSQCS1260
 1261 KEDGRSSSGP PHETAAPKRT YDMMEGRVGR TITSASIEGL MGRAIPEQHS PHLKEQHHIR1320
 1321 GSITQGIPRS YVEAQEDYLR REAKLLKREG TPPPPPPPRD LTETYKTRPL DPLGPLKLKP1380
 1381 THEGVVATVK EAGRSIHEIP REELRRTPEL PLAPRPLKEG SITQGTPLKY DSGVPSSGSK1440
 1441 KHDVRSIIGS PGRPFPALHP LDIMADARAL ERACYEESLK SRSGTSSGAG GSITRGAPVV1500
 1501 VPELGKPRQS PLAYEDHGAP FTSHLPRGSP VTTREPTPRL QEGSLLSSKA SQDRKLTSTP1560
 1561 REIAKSPHST VPEHHPHPIS PYEHLLRGVT GVDLYRGHIP LAFDPTSIPR GIPLEAAAAA1620
 1621 YYLPRHLAPS PTYPHLYPPY LIRGYPDTAA LENRQTIIND YITSQQMHHN AASAMAQRAD1680
 1681 MLRGLSPRES SLALNYAAGP RGIIDLSQVP HLPVLVPPTP GTPATAIDRL AYLPTAPPPF1740
 1741 SSRHSSSPLS PGGPTHLAKP TATSSSERER ERERERDKSI LTSTTTVEHA PIWRPGTEQS1800
 1801 SGAGGSSRPA SHTHQHSPIS PRTQDALQQR PSVLHNTSMK GVVTSVEPGT PTVLRWARST1860
 1861 STSSPVRPAA TFPPATHCPL GGTLEGVYPT LMEPVLLPKE TSRVTRPERP RVDAGHAFLT1920
 1921 KPPAREPASS PSKSSEPRSL APPSSSHTAI ARTPAKSLAP HHASPDLPAP TSASDLHREK1980
 1981 TQSKPFSIQE LELRSLGYHS GAGYSPDGVE PISPVSSPSL THDKGLSKPL EELEKSHLEG2040
 2041 ELRHKQPGPM KLSGEAAHLP HLRPLPESQP SSSPLLQTAP GIKGHQRVVT LAQHISEVIT2100
 2101 QDYTRHHPQQ LSGPLPAPLY SFPGASCPVL DLRRPPSDLY LPPPDHGTPA RGSPHSEGGK2160
 2161 RSPEPSKTVL SSSEDAIEPV SPPEGMTEPG HARSTAYPLL YRDGEQGEPR MGSKSPGNTS2220
 2221 QPPAFFSKLT ESNSAMVKSK KQEINKKLNT HNRNEPEYNI GQPGTEIFNM PAITGAGLMT2280
 2281 CRSQAVQEHA STNMGLEAII RKALMGKYDQ WEEPPPLGAN AFNPLNASAS LPAAAMPITT2340
 2341 ADGRSDHPLT SPGGGGKAKV SGRPSSRKAK SPAPGLAPGD RPPSVSSVHS EGDCNRRTPL2400
 2401 TNRVWEDRPS SAGSTPFPYN PLIMRLQAGV MASPPPPGLA AGSGPLAGPH HAWDEEPKPL2460
 2461 LCSQYETLSD SE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle