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Protein Overview: FBpp0311922, NetA-PA

General Information:
Name(s) found: FBpp0311922 [FlyBase]
NetA-PA / FBpp0073759 [FlyBase]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • type=protein; loc=X:complement(14498519..14498660,14498779..14499157,14500516..14500581,14504472..14504624,14504694..14504843,14514733..14514921,14546176..14547277); ID=FBpp0311922; name=NetA-PC; parent=FBgn0015773,FBtr0346088; dbxref=FlyBase:FBpp0311922,FlyBase_Annotation_IDs:CG18657-PC; MD5=f81b86e41da59643d91013f195ccbfd6; length=726; release=r5.56; species=Dmel; [FlyBase]
  • The gene Netrin-A is referred to in FlyBase by the symbol Dmel\NetA (CG18657, FBgn0015773). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14498045..14547864. It has the cytological map location 12F1-12F2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; dendrite guidance. 14 alleles are reported. The phenotypes of these alleles are annotated with: commissure; optic nerve; intersegmental nerve; lamina; transverse nerve; axon. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 726 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [ISS]
    proteinaceous extracellular matrix [ISS]
    Biological Process: motor axon guidance [IMP]
    axon guidance [ISS][NAS]
    dendrite guidance [IGI]
    Molecular Function: protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRGILLLLL GTTRFSPIQC ISNDVYFKMF SQQAPPEDPC YNKAHEPRAC IPDFVNAAYD  60
   61 APVVASSTCG SSGAQRYCEY QDHERSCHTC DMTDPLRSFP ARSLTDLNNS NNVTCWRSEP 120
  121 VTGSGDNVTL TLSLGKKFEL TYVILQLCPH APRPDSMVIY KSTDHGLSWQ PFQFFSSQCR 180
  181 RLFGRPARQS TGRHNEHEAR CSDVTRPLVS RIAFSTLEGR PSSRDLDSSP VLQDWVTATD 240
  241 IRVVFHRLQR PDPQALLSLE AGGATDLASG KYSVPLANGP AGNNIEANLG GDVATSGSGL 300
  301 HYAISDFSVG GRCKCNGHAS KCSTDASGQL NCECSHNTAG RDCERCKPFH FDRPWARATA 360
  361 KEANECKECN CNKHARQCRF NMEIFRLSQG VSGGVCQNCR HSTTGRNCHQ CKEGFYRDAT 420
  421 KPLTHRKVCK ACDCHPIGSS GKICNSTSGQ CPCKDGVTGL TCNRCARGYQ QSRSHIAPCI 480
  481 KQPPRMINML DTQNTAPEPD EPESSPGSGG DRNGAAGMAA QSQYYRTEGG RECGKCRVST 540
  541 KRLNLNKFCK RDYAIMAKVI GRDTSSEAVS REVQRRAMDP DVADYEMDQV QPGSARSPIT 600
  601 GVYEFQAADY PNPNPNPRGS EMERFDLQIQ AVFKRSRPGE SSGAGNVYGM PNTTLKRGPM 660
  661 TWIIPTKDLE CRCPRIRVNR SYLILGRDSE APPGYLGIGP HSIVIEWKED WYRRMKRFQR 720
  721 RARTCA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..262] FFAS03 1.47 No description for 2jd9A was found.
    2 View Details [263..650] PSI-BLAST 9.0 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    3 View Details [651..726] FFAS03 3.58 Procollagen c-proteinase enhancer protein PCOLCE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • growth factor activity
    		•  4.72461268561406 bayes_pls_golite062009
  • receptor binding
    		•  4.33045214660893 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  3.94919760633279 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  3.49243532917035 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  3.35388192361449 bayes_pls_golite062009
  • heparin binding
    		•  3.18889412817519 bayes_pls_golite062009
  • protein binding
    		•  3.02592228806142 bayes_pls_golite062009
  • polysaccharide binding
    		•  2.79319890241656 bayes_pls_golite062009
  • binding
    		•  2.54996368217395 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.50577000783584 bayes_pls_golite062009
  • pattern binding
    		•  1.70788251788028 bayes_pls_golite062009
  • transcription factor binding
    		•  1.57104729053305 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.47966998696701 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  0.97849904249419 bayes_pls_golite062009
  • signal transducer activity
    		•  0.779677131640727 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.779677131640727 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.66981956037474 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.37481112933019 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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