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View Structure Prediction Details

Protein: FBpp0311922, NetA-PA
Organism: Drosophila melanogaster
Length: 726 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0311922, NetA-PA.

Description E-value Query
Range
Subject
Range
gi|1407707 - gi|1407707|gb|AAB17533.1| Netrin-A [Drosophila melanogaster]
392.0 [0..15] [726..15]

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Predicted Domain #1
Region A:
Residues: [1-262]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRGILLLLL GTTRFSPIQC ISNDVYFKMF SQQAPPEDPC YNKAHEPRAC IPDFVNAAYD  60
   61 APVVASSTCG SSGAQRYCEY QDHERSCHTC DMTDPLRSFP ARSLTDLNNS NNVTCWRSEP 120
  121 VTGSGDNVTL TLSLGKKFEL TYVILQLCPH APRPDSMVIY KSTDHGLSWQ PFQFFSSQCR 180
  181 RLFGRPARQS TGRHNEHEAR CSDVTRPLVS RIAFSTLEGR PSSRDLDSSP VLQDWVTATD 240
  241 IRVVFHRLQR PDPQALLSLE AG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.47
Match: 2jd9A
Description: No description for 2jd9A was found.

Predicted Domain #2
Region A:
Residues: [263-650]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GATDLASGKY SVPLANGPAG NNIEANLGGD VATSGSGLHY AISDFSVGGR CKCNGHASKC  60
   61 STDASGQLNC ECSHNTAGRD CERCKPFHFD RPWARATAKE ANECKECNCN KHARQCRFNM 120
  121 EIFRLSQGVS GGVCQNCRHS TTGRNCHQCK EGFYRDATKP LTHRKVCKAC DCHPIGSSGK 180
  181 ICNSTSGQCP CKDGVTGLTC NRCARGYQQS RSHIAPCIKQ PPRMINMLDT QNTAPEPDEP 240
  241 ESSPGSGGDR NGAAGMAAQS QYYRTEGGRE CGKCRVSTKR LNLNKFCKRD YAIMAKVIGR 300
  301 DTSSEAVSRE VQRRAMDPDV ADYEMDQVQP GSARSPITGV YEFQAADYPN PNPNPRGSEM 360
  361 ERFDLQIQAV FKRSRPGESS GAGNVYGM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.0
Match: 1n7dA
Description: Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
growth factor activity 4.72461268561406 bayes_pls_golite062009
receptor binding 4.33045214660893 bayes_pls_golite062009
ErbB-2 class receptor binding 3.94919760633279 bayes_pls_golite062009
glycosaminoglycan binding 3.49243532917035 bayes_pls_golite062009
ErbB-3 class receptor binding 3.35388192361449 bayes_pls_golite062009
heparin binding 3.18889412817519 bayes_pls_golite062009
protein binding 3.02592228806142 bayes_pls_golite062009
polysaccharide binding 2.79319890241656 bayes_pls_golite062009
binding 2.54996368217395 bayes_pls_golite062009
transcription regulator activity 2.50577000783584 bayes_pls_golite062009
pattern binding 1.70788251788028 bayes_pls_golite062009
transcription factor binding 1.57104729053305 bayes_pls_golite062009
transcription cofactor activity 1.47966998696701 bayes_pls_golite062009
epidermal growth factor receptor binding 0.97849904249419 bayes_pls_golite062009
signal transducer activity 0.779677131640727 bayes_pls_golite062009
molecular transducer activity 0.779677131640727 bayes_pls_golite062009
extracellular matrix structural constituent 0.66981956037474 bayes_pls_golite062009
carbohydrate binding 0.37481112933019 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [651-726]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNTTLKRGPM TWIIPTKDLE CRCPRIRVNR SYLILGRDSE APPGYLGIGP HSIVIEWKED  60
   61 WYRRMKRFQR RARTCA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.58
Match: 1uapA
Description: Procollagen c-proteinase enhancer protein PCOLCE
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle