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Protein Overview: MUTL_ECOLI

General Information:
Name(s) found: MUTL_ECOLI [Swiss-Prot]
Description(s) found:
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  • pir||PH0853 methyl-directed mismatch repair protein mutL - Escherichia coli (strain K-12) [NCBI NR]
  • gi|537011|gb|AAA97066.1| CG Site No. 470; alternate gene name mut-25 [Escherichia coli] [NCBI NR]
  • gi|42067|emb|CAA77850.1| MutL Protein [Escherichia coli] [NCBI NR]
  • gi|17017338|gb|AAL33626.1|AF440199_1 MutL [Escherichia coli] [NCBI NR]
  • gi|127552|sp|P23367.2|MUTL_ECOLI RecName: Full=DNA mismatch repair protein mutL [NCBI NR]
  • DNA mismatch repair protein mutL - Escherichia coli [Swiss-Prot]
  • enzyme in methyl-directed mismatch repair; enzyme in methyl-directed mismatch repair, stimulates binding of Vsr and MutS to heteroduplex DNA [Escherichia coli K12]gi|17017338|gb|AAL33626.1| MutL [Escherichia coli]gi|1790612|gb|AAC77127.1| enzyme in meth [nrdb_11152004_Chlamydomonas]
  • DNA mismatch repair protein mutL [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • CG Site No. 470; alternate gene name mut-25 [Escherichia coli] [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • MutL Protein [Escherichia coli] [nr-271106-contam.fasta]
  • MutL [Escherichia coli] [nr-271106-contam.fasta]
  • DNA mismatch repair protein mutL OS=Escherichia coli (strain K12) GN=mutL PE=1 SV=2 [uniprot-Ecoli-reviewed-110511.fasta]
  • DNA mismatch repair protein MutL OS=Escherichia coli (strain K12) GN=mutL PE=1 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Escherichia coli
    Length: 615 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG  60
   61 CGIKKDELAL ALARHATSKI ASLDDLEAII SLGFRGEALA SISSVSRLTL TSRTAEQQEA 120
  121 WQAYAEGRDM NVTVKPAAHP VGTTLEVLDL FYNTPARRKF LRTEKTEFNH IDEIIRRIAL 180
  181 ARFDVTINLS HNGKIVRQYR AVPEGGQKER RLGAICGTAF LEQALAIEWQ HGDLTLRGWV 240
  241 ADPNHTTPAL AEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD 300
  301 VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQLETPLPL DDEPQPAPRS IPENRVAAGR 360
  361 NHFAEPAARE PVAPRYTPAP ASGSRPAAPW PNAQPGYQKQ QGEVYRQLLQ TPAPMQKLKA 420
  421 PEPQEPALAA NSQSFGRVLT IVHSDCALLE RDGNISLLSL PVAERWLRQA QLTPGEAPVC 480
  481 AQPLLIPLRL KVSAEEKSAL EKAQSALAEL GIDFQSDAQH VTIRAVPLPL RQQNLQILIP 540
  541 ELIGYLAKQS VFEPGNIAQW IARNLMSEHA QWSMAQAITL LADVERLCPQ LVKTPPGGLL 600
  601 QSVDLHPAIK ALKDE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..350] PSI-BLAST 87.69897 DNA mismatch repair protein MutL
    2 View Details [351..442] PSI-BLAST 18.221849 No description for 2cgeA was found.
    3 View Details [443..615] PSI-BLAST 28.522879 Crystal structure of the MutL C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mismatched DNA binding
    		•  8.69038541722775 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  7.03361327424191 bayes_pls_golite062009
    		• 6.04882684441736 bayes_pls_golite062009
  • guanine/thymine mispair binding
    		•  5.8954303695758 bayes_pls_golite062009
  • mismatch repair complex binding
    		•  5.63566878749852 bayes_pls_golite062009
  • single base insertion or deletion binding
    		•  5.36719395837475 bayes_pls_golite062009
  • dinucleotide insertion or deletion binding
    		•  4.91072939712457 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  4.30742933993291 bayes_pls_golite062009
  • loop DNA binding
    		•  4.26052361441101 bayes_pls_golite062009
  • MutSalpha complex binding
    		•  3.98449516092015 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  2.94622218217238 bayes_pls_golite062009
  • DNA topoisomerase (ATP-hydrolyzing) activity
    		•  2.66323092512867 bayes_pls_golite062009
  • DNA topoisomerase activity
    		•  2.35776058207527 bayes_pls_golite062009
  • catalytic activity
    		•  2.10890475146569 bayes_pls_golite062009
  • protein kinase activity
    		•  1.84867054522487 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.60156177836014 bayes_pls_golite062009
  • kinase activity
    		•  1.56098992648511 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.53059432571568 bayes_pls_golite062009
  • centromeric DNA binding
    		•  1.14717297489632 bayes_pls_golite062009
  • transferase activity
    		•  1.09369139087478 bayes_pls_golite062009
  • signal transducer activity
    		•  0.996368427522977 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.996368427522977 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.86218415868631 bayes_pls_golite062009
  • exonuclease activity
    		•  0.76163144715311 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.71251019785001 bayes_pls_golite062009
  • nuclease activity
    		•  0.42266682237543 bayes_pls_golite062009
  • structural molecule activity
    		•  0.41673693977319 bayes_pls_golite062009
  • DNA binding
    		•  0.354386854508935 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.350127505292197 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.339546157228275 bayes_pls_golite062009
  • binding
    		•  0.269048901178327 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.0675296198098132 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle