YRC Public Data Repository - Protein Structure Prediction

Protein:	MUTL_ECOLI
Organism:	Escherichia coli
Length:	615 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MUTL_ECOLI.

Description	E-value	Query Range	Subject Range
MUTL_PSEPK - DNA mismatch repair protein MutL OS=Pseudomonas putida (strain KT2440) GN=mutL PE=3 SV=1	486.0	[0..1]	[612..1]
gi\|148549974, gi... - gi\|82738817\|ref\|ZP_00901641.1\| DNA mismatch repair protein [Pseudomonas putida F1], gi\|82714129\|gb\|E...	485.0	[0..1]	[612..2]
MUTL_PSEE4 - DNA mismatch repair protein MutL OS=Pseudomonas entomophila (strain L48) GN=mutL PE=3 SV=1 gi\|95112861 - gi\|95112861\|emb\|CAK17589.1\| DNA mismatch repair protein MutL [Pseudomonas entomophila L48]	484.0	[0..1]	[612..1]
gi\|77380752, gi\|... - gi\|77456749\|ref\|YP_346254.1\| DNA mismatch repair protein [Pseudomonas fluorescens Pf0-1], gi\|7738075...	476.0	[0..3]	[612..10]
MUTL_PSEA7 - DNA mismatch repair protein MutL OS=Pseudomonas aeruginosa (strain PA7) GN=mutL PE=3 SV=1	475.0	[0..1]	[612..1]
gi\|90022314, gi\|... - gi\|90022314\|ref\|YP_528141.1\| DNA mismatch repair protein [Saccharophagus degradans 2-40], gi\|8995191...	474.0	[0..1]	[612..1]
gi\|30065542, gi\|... - gi\|30065542\|ref\|NP_839713.1\| DNA mismatch repair protein [Shigella flexneri 2a str. 2457T], gi\|30043... gi\|56384136, gi\|... - gi\|56480585\|ref\|NP_710035.2\| DNA mismatch repair protein [Shigella flexneri 2a str. 301], gi\|5638413... MUTL_SHIFL - DNA mismatch repair protein MutL OS=Shigella flexneri GN=mutL PE=3 SV=4	473.0	[0..1]	[615..1]
MUTL_PSEAB - DNA mismatch repair protein MutL OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=mutL PE=3 SV=1 gi\|107104045 - gi\|107104045\|ref\|ZP_01367963.1\| hypothetical protein PaerPA_01005118 [Pseudomonas aeruginosa PACS2]	473.0	[0..1]	[612..1]
MUTL_PSEAE - DNA mismatch repair protein MutL OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 ... gi\|126170270, gi... - gi\|84317612\|ref\|ZP_00966051.1\| COG0323: DNA mismatch repair enzyme (predicted ATPase) [Pseudomonas a... MUTL_PSEAE - DNA mismatch repair protein mutL OS=Pseudomonas aeruginosa GN=mutL PE=3 SV=1 MUTL_PSEA8 - DNA mismatch repair protein MutL OS=Pseudomonas aeruginosa (strain LESB58) GN=mutL PE=3 SV=1	473.0	[0..1]	[612..1]
MUTL_ECOL5 - DNA mismatch repair protein MutL OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=mutL PE=3 SV=... MUTL_ECOK1 - DNA mismatch repair protein MutL OS=Escherichia coli O1:K1 / APEC GN=mutL PE=3 SV=1 gi\|190905205, gi... - gi\|75236177\|ref\|ZP_00720299.1\| COG0323: DNA mismatch repair enzyme (predicted ATPase) [Escherichia c... gi\|226901749, gi... - gi\|237703837\|ref\|ZP_04534318.1\| MutL [Escherichia sp. 3_2_53FAA], gi\|226901749\|gb\|EEH88008.1\| MutL [... MUTL_ECO45 - DNA mismatch repair protein MutL OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=mutL PE=3 SV=1	473.0	[0..1]	[615..1]

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Predicted Domain #1

Region A:
Residues: [1-350]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG  60
   61 CGIKKDELAL ALARHATSKI ASLDDLEAII SLGFRGEALA SISSVSRLTL TSRTAEQQEA 120
  121 WQAYAEGRDM NVTVKPAAHP VGTTLEVLDL FYNTPARRKF LRTEKTEFNH IDEIIRRIAL 180
  181 ARFDVTINLS HNGKIVRQYR AVPEGGQKER RLGAICGTAF LEQALAIEWQ HGDLTLRGWV 240
  241 ADPNHTTPAL AEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD 300
  301 VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQLETPLPL DDEPQPAPRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	87.69897
Match:	1bknA
Description:	DNA mismatch repair protein MutL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
mismatched DNA binding	8.69038541722775	bayes_pls_golite062009
DNA insertion or deletion binding	7.03361327424191	bayes_pls_golite062009
	6.04882684441736	bayes_pls_golite062009
guanine/thymine mispair binding	5.8954303695758	bayes_pls_golite062009
mismatch repair complex binding	5.63566878749852	bayes_pls_golite062009
single base insertion or deletion binding	5.36719395837475	bayes_pls_golite062009
dinucleotide insertion or deletion binding	4.91072939712457	bayes_pls_golite062009
double-stranded DNA binding	4.30742933993291	bayes_pls_golite062009
loop DNA binding	4.26052361441101	bayes_pls_golite062009
MutSalpha complex binding	3.98449516092015	bayes_pls_golite062009
DNA secondary structure binding	2.94622218217238	bayes_pls_golite062009
DNA topoisomerase (ATP-hydrolyzing) activity	2.66323092512867	bayes_pls_golite062009
DNA topoisomerase activity	2.35776058207527	bayes_pls_golite062009
catalytic activity	2.10890475146569	bayes_pls_golite062009
protein kinase activity	1.84867054522487	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.60156177836014	bayes_pls_golite062009
kinase activity	1.56098992648511	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.53059432571568	bayes_pls_golite062009
centromeric DNA binding	1.14717297489632	bayes_pls_golite062009
transferase activity	1.09369139087478	bayes_pls_golite062009
signal transducer activity	0.996368427522977	bayes_pls_golite062009
molecular transducer activity	0.996368427522977	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.86218415868631	bayes_pls_golite062009
exonuclease activity	0.76163144715311	bayes_pls_golite062009
structural constituent of ribosome	0.71251019785001	bayes_pls_golite062009
nuclease activity	0.42266682237543	bayes_pls_golite062009
structural molecule activity	0.41673693977319	bayes_pls_golite062009
DNA binding	0.354386854508935	bayes_pls_golite062009
nucleic acid binding	0.350127505292197	bayes_pls_golite062009
transcription regulator activity	0.339546157228275	bayes_pls_golite062009
binding	0.269048901178327	bayes_pls_golite062009
ribonuclease activity	0.0675296198098132	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [351-442]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPENRVAAGR NHFAEPAARE PVAPRYTPAP ASGSRPAAPW PNAQPGYQKQ QGEVYRQLLQ  60
   61 TPAPMQKLKA PEPQEPALAA NSQSFGRVLT IV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.221849
Match:	2cgeA
Description:	No description for 2cgeA was found.

Predicted Domain #3

Region A:
Residues: [443-615]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSDCALLERD GNISLLSLPV AERWLRQAQL TPGEAPVCAQ PLLIPLRLKV SAEEKSALEK  60
   61 AQSALAELGI DFQSDAQHVT IRAVPLPLRQ QNLQILIPEL IGYLAKQSVF EPGNIAQWIA 120
  121 RNLMSEHAQW SMAQAITLLA DVERLCPQLV KTPPGGLLQS VDLHPAIKAL KDE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	28.522879
Match:	1x9zA
Description:	Crystal structure of the MutL C-terminal domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: