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Protein Overview: CaMKII-PI, CaMKII-PD

General Information:
Name(s) found: CaMKII-PI / FBpp0289607 [FlyBase]
CaMKII-PD / FBpp0099496 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • The gene Calcium/calmodulin-dependent protein kinase II is referred to in FlyBase by the symbol Dmel\CaMKII (CG18069, FBgn0004624). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1056643..1074329. It has the cytological map location 102F6-102F7. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; learning or memory; regulation of filopodium assembly; long-term memory; male courtship behavior. 14 alleles are reported. The phenotypes of these alleles are annotated with: adult abdomen; neuromuscular junction; larval neuromuscular junction; wing. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
  • The gene Calcium/calmodulin-dependent protein kinase II is referred to in FlyBase by the symbol Dmel\CaMKII (CG18069, FBgn0004624). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1056643..1074329. It has the cytological map location 102F6-102F7. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity; calmodulin-dependent protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; learning or memory; regulation of filopodium assembly; long-term memory; male courtship behavior. 14 alleles are reported. The phenotypes of these alleles are annotated with: adult abdomen; neuromuscular junction; larval neuromuscular junction; wing. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 530 amino acids

    Gene Ontology:
    Cellular Component: calcium- and calmodulin-dependent protein kinase complex [ISS]
    dendrite [IDA]
    presynaptic active zone [IDA]
    postsynaptic membrane [IDA]
    axon [IDA]
    Biological Process: neuromuscular junction development [NAS]
    long-term memory [IMP]
    regulation of filopodium assembly [IMP]
    courtship behavior [TAS]
    male courtship behavior [IMP]
    synaptic transmission [IMP]
    protein amino acid phosphorylation [IEA][NAS][TAS]
    learning or memory [IMP][NAS]
    Molecular Function: ATP binding [IEA]
    calmodulin binding [IEA][TAS]
    calmodulin-dependent protein kinase activity [IDA][ISS]
    protein serine/threonine kinase activity [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPAACTRF SDNYDIKEEL GKGAFSIVKR CVQKSTGFEF AAKIINTKKL TARDFQKLER  60
   61 EARICRKLHH PNIVRLHDSI QEENYHYLVF DLVTGGELFE DIVAREFYSE ADASHCIQQI 120
  121 LESVNHCHQN GVVHRDLKPE NLLLASKAKG AAVKLADFGL AIEVQGDHQA WFGFAGTPGY 180
  181 LSPEVLKKEP YGKSVDIWAC GVILYILLVG YPPFWDEDQH RLYSQIKAGA YDYPSPEWDT 240
  241 VTPEAKNLIN QMLTVNPNKR ITAAEALKHP WICQRERVAS VVHRQETVDC LKKFNARRKL 300
  301 KGAILTTMLA TRNFSSRSMI TKKGEGSQVK ESTDSSSTTL EDDDIKEDKK GTVDRSTTVV 360
  361 SKEPEDIRIL CPAKTYQQNI GNSQCSSARR QEIIKITEQL IEAINSGDFD GYTKICDPHL 420
  421 TAFEPEALGN LVEGIDFHKF YFENVLGKNC KAINTTILNP HVHLLGEEAA CIAYVRLTQY 480
  481 IDKQGHAHTH QSEETRVWHK RDNKWQNVHF HRSASAKISG ATTFDFIPQK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..293] PSI-BLAST 83.0 No description for 2v7oA was found.
    2 View Details [294..465] PSI-BLAST 18.39794 Regulatory apparatus of Calcium Dependent protein kinase from Arabidopsis thaliana
    3 View Details [466..530] PSI-BLAST 53.522879 No description for 2ux0A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.60

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle