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Protein Overview: ISPG_ECOLI

General Information:
Name(s) found: ISPG_ECOLI [Swiss-Prot]
Description(s) found:
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  • pir||S23058 gcpE protein - Escherichia coli (strain K-12) [NCBI NR]
  • gi|50402178|sp|P62620.1|ISPG_ECOLI RecName: Full=4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; AltName: Full=1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; AltName: Full=Protein gcpE; Short=Protein E [NCBI NR]
  • gi|41542|emb|CAA45783.1| gcpE [Escherichia coli] [NCBI NR]
  • gi|382203|prf||1819264A gcpE gene [NCBI NR]
  • pir||E85895 hypothetical protein gcpE [imported] - Escherichia coli (strain O157:H7, substrain EDL933) [NCBI NR]
  • pir||A91051 hypothetical protein ECs3377 [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952) [NCBI NR]
  • gi|209763386|gb|ACI80005.1| hypothetical protein ECs3377 [Escherichia coli] [NCBI NR]
  • gi|209763382|gb|ACI80003.1| hypothetical protein ECs3377 [Escherichia coli] [NCBI NR]
  • gi|209763380|gb|ACI80002.1| hypothetical protein ECs3377 [Escherichia coli] [NCBI NR]
  • gi|209763378|gb|ACI80001.1| hypothetical protein ECs3377 [Escherichia coli] [NCBI NR]
  • gi|17978528|gb|AAK53460.1| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase [Escherichia coli] [NCBI NR]
  • 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.4.3) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) (Protein gcpE) (Protein E) - Escherichia coli [Swiss-Prot]
  • 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; putative enzyme involved in formation of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate [Escherichia coli K12]gi|15832631|ref|NP_311404.1| hypothetical protein ECs3377 [Escherichia coli O157:H7]gi [nrdb_11152004_Chlamydomonas]
  • 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) (Protein gcpE) (Protein E) [NCBI-RefSeq_human_na_08-09-2006_reversed.fasta]
  • 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase [Escherichia coli] [nr-271106-contam.fasta]
  • gcpE [Escherichia coli] [nr-271106-contam.fasta]
  • gcpE gene [nr-271106-contam.fasta]
  • 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase OS=Escherichia coli (strain K12) GN=ispG PE=1 SV=1 [uniprot-Ecoli-reviewed-110511.fasta]
  • 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Escherichia coli (strain K12) GN=ispG PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Escherichia coli
    Length: 372 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHNQAPIQRR KSTRIYVGNV PIGDGAPIAV QSMTNTRTTD VEATVNQIKA LERVGADIVR  60
   61 VSVPTMDAAE AFKLIKQQVN VPLVADIHFD YRIALKVAEY GVDCLRINPG NIGNEERIRM 120
  121 VVDCARDKNI PIRIGVNAGS LEKDLQEKYG EPTPQALLES AMRHVDHLDR LNFDQFKVSV 180
  181 KASDVFLAVE SYRLLAKQID QPLHLGITEA GGARSGAVKS AIGLGLLLSE GIGDTLRVSL 240
  241 AADPVEEIKV GFDILKSLRI RSRGINFIAC PTCSRQEFDV IGTVNALEQR LEDIITPMDV 300
  301 SIIGCVVNGP GEALVSTLGV TGGNKKSGLY EDGVRKDRLD NNDMIDQLEA RIRAKASQLD 360
  361 EARRIDVQQV EK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..201] FFAS03 1.53 Crystal structure of a cyclase subunit of imidazolglycerolphosphate synthase
    2 View Details [202..372] PSI-BLAST 31.0 SULFITE REDUCTASE STRUCTURE AT 1.6 ANGSTROM RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  2.23978286968274 bayes_pls_golite062009
  • ribulose-phosphate 3-epimerase activity
    		•  1.74315876678296 bayes_pls_golite062009
  • racemase and epimerase activity, acting on carbohydrates and derivatives
    		•  0.436867325900229 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting aldoses and ketoses
    		•  0.288873045228069 bayes_pls_golite062009
  • carboxy-lyase activity
    		•  0.255198687020834 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  0.199710740108037 bayes_pls_golite062009
    2
    Term Confidence Notes
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  0.80851296667151 bayes_pls_golite062009
  • catalytic activity
    		•  0.767627914425245 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  0.106592424462903 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle