YRC Public Data Repository - Protein Structure Prediction

Protein:	ISPG_ECOLI
Organism:	Escherichia coli
Length:	372 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISPG_ECOLI.

Description	E-value	Query Range	Subject Range
ISPG_CHRSD - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Chromohalobacter salexigens (st...	553.0	[0..1]	[369..1]
ISPG_AZOVD - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Azotobacter vinelandii (strain ... gi\|53612553, gi\|... - gi\|67156528\|ref\|ZP_00418121.1\| IspG protein [Azotobacter vinelandii AvOP], ref\|ZP_00342610.1\| COG082...	549.0	[0..1]	[354..1]
gi\|94426701, gi\|... - gi\|94501125\|ref\|ZP_01307648.1\| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase [Oceanobacter sp...	548.0	[0..5]	[371..7]
gi\|88799905, gi\|... - gi\|88799905\|ref\|ZP_01115477.1\| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase [Reinekea sp. ME...	545.0	[0..2]	[368..4]
ISPG_HAHCH - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Hahella chejuensis (strain KCTC...	544.0	[0..1]	[362..1]
ISPG_PSEAE - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase OS=Pseudomonas aeruginosa GN=ispG PE=3 SV=1 ISPG_PSEAE - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Pseudomonas aeruginosa (strain ... ISPG_PSEAB - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Pseudomonas aeruginosa (strain ... gi\|254242494, gi... - gi\|254242494\|ref\|ZP_04935816.1\| hypothetical protein PA2G_03244 [Pseudomonas aeruginosa 2192], gi\|19... gi\|254236707, gi... - gi\|254236707\|ref\|ZP_04930030.1\| hypothetical protein PACG_02717 [Pseudomonas aeruginosa C3719], gi\|1... ISPG_PSEA8 - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Pseudomonas aeruginosa (strain ...	540.0	[0..1]	[353..3]
ISPG_MARHV - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Marinobacter hydrocarbonoclasti...	540.0	[0..1]	[368..1]
gi\|86166111, gi\|... - gi\|87118477\|ref\|ZP_01074376.1\| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase [Marinomonas sp....	538.0	[0..1]	[362..1]
ISPG_PSESM - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Pseudomonas syringae pv. tomato... ISPG_PSESM - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase OS=Pseudomonas syringae pv. tomato GN=ispG PE=3... gi\|213971518, gi... - gi\|213971518\|ref\|ZP_03399629.1\| 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase [Pseudomonas...	537.0	[0..1]	[364..1]
ISPG_PSEPK - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) OS=Pseudomonas putida (strain KT24... tr\|E4R533\|E4R533... - 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase OS=Pseudomonas putida (strain BIRD-1) GN=ispG P...	537.0	[0..1]	[353..1]

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Predicted Domain #1

Region A:
Residues: [1-201]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHNQAPIQRR KSTRIYVGNV PIGDGAPIAV QSMTNTRTTD VEATVNQIKA LERVGADIVR  60
   61 VSVPTMDAAE AFKLIKQQVN VPLVADIHFD YRIALKVAEY GVDCLRINPG NIGNEERIRM 120
  121 VVDCARDKNI PIRIGVNAGS LEKDLQEKYG EPTPQALLES AMRHVDHLDR LNFDQFKVSV 180
  181 KASDVFLAVE SYRLLAKQID Q

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.53
Match:	1vh7A
Description:	Crystal structure of a cyclase subunit of imidazolglycerolphosphate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.23978286968274	bayes_pls_golite062009
ribulose-phosphate 3-epimerase activity	1.74315876678296	bayes_pls_golite062009
racemase and epimerase activity, acting on carbohydrates and derivatives	0.436867325900229	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	0.288873045228069	bayes_pls_golite062009
carboxy-lyase activity	0.255198687020834	bayes_pls_golite062009
intramolecular oxidoreductase activity	0.199710740108037	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [202-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLHLGITEAG GARSGAVKSA IGLGLLLSEG IGDTLRVSLA ADPVEEIKVG FDILKSLRIR  60
   61 SRGINFIACP TCSRQEFDVI GTVNALEQRL EDIITPMDVS IIGCVVNGPG EALVSTLGVT 120
  121 GGNKKSGLYE DGVRKDRLDN NDMIDQLEAR IRAKASQLDE ARRIDVQQVE K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.0
Match:	1aopA
Description:	SULFITE REDUCTASE STRUCTURE AT 1.6 ANGSTROM RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	0.80851296667151	bayes_pls_golite062009
catalytic activity	0.767627914425245	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	0.106592424462903	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: