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Protein Overview: FOXD3_RAT

General Information:
Name(s) found: FOXD3_RAT [Swiss-Prot]
Description(s) found:
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  • gi|3913827|sp|Q63245.1|FOXD3_RAT RecName: Full=Forkhead box protein D3; AltName: Full=Hepatocyte nuclear factor 3 forkhead homolog 2; Short=HFH-2; AltName: Full=HNF3/FH transcription factor genesis [NCBI NR]
  • gi|310155|gb|AAA41319.1| HNF-3/fork-head homolog-2 [NCBI NR]
  • pir||I60917 HNF-3/fork-head homolog-2 - rat (fragment) [NCBI NR]
  • (Q63245) Forkhead box protein D3 (HNF3/FH transcription factor genesis) (Hepatocyte nuclear factor 3 forkhead homolog 2) (HFH-2) (Fragment) [Swiss-Prot]
  • Forkhead box protein D3 (Fragment) OS=Rattus norvegicus GN=Foxd3 PE=1 SV=1 [Swiss-Prot]
  • HNF-3/fork-head homolog-2 - rat (fragment)gi|310155|gb|AAA41319.1| HNF-3/fork-head homolog-2gi|3913827|sp|Q63245|FXD3_RAT Forkhead box protein D3 (HNF3/FH transcription factor genesis) (Hepatocyte nuclear factor 3 forkhead homolog 2) (HFH-2) [nrdb_11152004_Chlamydomonas]
  • Forkhead box protein D3 (Hepatocyte nuclear factor 3 forkhead homolog 2) (HFH-2) (HNF3/FH transcription factor genesis) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • HNF-3/fork-head homolog-2 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Forkhead box protein D3 (HNF3/FH transcription factor genesis) (Hepatocyte nuclear factor 3 forkhead homolog 2) (HFH-2) [nr-271106-contam.fasta]
  • Forkhead box protein D3 (Fragment) OS=Rattus norvegicus GN=Foxd3 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 101 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [ISS]
    in utero embryonic development [ISS]
    multicellular organismal development [IEA]
    regulation of transcription, DNA-dependent [IEA][TAS]
    trophectodermal cell differentiation [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][ISS]
    embryonic placenta development [UNKNOWN][IEA]
    Molecular Function: DNA binding [IDA]
    transcription factor activity [IEA][ISS]
    protein binding [UNKNOWN][IEA]
    double-stranded DNA binding [IMP]
    sequence-specific DNA binding [IEA]
    promoter binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVKPPYSYIA LITMAILQSP QKKLTLSGIC EFISNRFPYY REKFPAWQNS IRHNLSLNDC  60
   61 FVKIPREPGN PGKGNYWTLD PQSEDMFDNG SFLRRRKRFK R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] PSI-BLAST 41.522879 Genesis

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • transcription activator activity
    		•  3.70589483230587 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.58179858678904 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.2723726467408 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle