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Protein Overview: HSD17B1

General Information:
Name(s) found: HSD17B1 [HGNC (HUGO)]
Description(s) found:
Found 26 descriptions.
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  • hydroxysteroid (17-beta) dehydrogenase 1 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARTVVLITGC SSGIGLHLAV RLASDPSQSF KVYATLRDLK TQGRLWEAAR ALACPPGSLE  60
   61 TLQLDVRDSK SVAAARERVT EGRVDVLVCN AGLGLLGPLE ALGEDAVASV LDVNVVGTVR 120
  121 MLQAFLPDMK RRGSGRVLVT GSVGGLMGLP FNDVYCASKF ALEGLCESLA VLLLPFGVHL 180
  181 SLIECGPVHT AFMEKVLGSP EEVLDRTDIH TFHRFYQYLA HSKQVFREAA QNPEEVAEVF 240
  241 LTALRAPKPT LRYFTTERFL PLLRMRLDDP SGSNYVTAMH REVFGDVPAK AEAGAEAGGG 300
  301 AGPGAEDEAG RSAVGDPELG DPPAAPQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. HSD17B1 gi|112491310

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..327] PSI-BLAST 56.69897 HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • retinol dehydrogenase activity
    		•  3.10587467349583 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.8894480857983 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.867909552357575 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.82673050487418 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.824879127880521 bayes_pls_golite062009
  • binding
    		•  0.784517759335365 bayes_pls_golite062009
  • retinol binding
    		•  0.343379136183648 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.311551606659739 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  0.27189038644972 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.220014544038474 bayes_pls_golite062009
  • signal transducer activity
    		•  0.220014544038474 bayes_pls_golite062009
  • channel activity
    		•  0.166857973838454 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.166857973838454 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.14195924411997 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.135469305070471 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.100470710829263 bayes_pls_golite062009
  • DNA binding
    		•  0.0824412435540247 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.0822919343613215 bayes_pls_golite062009
  • receptor activity
    		•  0.0665855982136239 bayes_pls_golite062009
  • ion channel activity
    		•  0.0487923057681532 bayes_pls_golite062009
  • ethanol binding
    		•  0.0448614072391299 bayes_pls_golite062009
  • gated channel activity
    		•  0.015794644474568 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.70

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle