YRC Public Data Repository - Protein Structure Prediction

Protein:	HSD17B1
Organism:	Homo sapiens
Length:	327 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSD17B1.

Description	E-value	Query Range	Subject Range
gi\|115250215, gi... - gi\|126698778\|ref\|YP_001087675.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile 6... gi\|255306086 - gi\|255306086\|ref\|ZP_05350258.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile AT... gi\|255100197 - gi\|255100197\|ref\|ZP_05329174.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC...	282.0	[0..2]	[267..6]
gi\|255313843 - gi\|255313843\|ref\|ZP_05355426.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255516524 - gi\|255516524\|ref\|ZP_05384200.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255649624 - gi\|255649624\|ref\|ZP_05396526.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|254974717 - gi\|254974717\|ref\|ZP_05271189.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255092105 - gi\|255092105\|ref\|ZP_05321583.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile CI... gi\|90575404, gi\|... - gi\|90575404\|ref\|ZP_01231888.1\| hypothetical protein CdifQ_02001165 [Clostridium difficile QCD-32g58]...	281.0	[0..2]	[267..6]
gi\|146296617, gi... - gi\|82501013\|ref\|ZP_00886394.1\| 3-oxoacyl-(acyl-carrier-protein) reductase [Caldicellulosiruptor sacc...	279.0	[0..3]	[267..7]
gi\|18310052, gi\|... - gi\|18310052\|ref\|NP_561986.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens st...	275.0	[0..3]	[267..5]
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1 FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...	273.0	[0..2]	[266..5]
gi\|168210762, gi... - gi\|170711222\|gb\|EDT23404.1\| 3-oxoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens B st... gi\|110675446, gi... - gi\|110800799\|ref\|YP_695772.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens A... gi\|170660709, gi... - gi\|170660709\|gb\|EDT13392.1\| 3-oxoacyl- reductase [Clostridium perfringens E str. JGS1987], gi\|168207...	271.0	[0..3]	[267..5]
gi\|1502421 - gi\|1502421\|gb\|AAC44307.1\| 3-ketoacyl-acyl carrier protein reductase gi\|1502421\|gb\|AA... - 3-ketoacyl-acyl carrier protein reductase	270.0	[0..3]	[267..5]
gi\|221313791 - gi\|221313791\|ref\|ZP_03595596.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... gi\|221318715 - gi\|221318715\|ref\|ZP_03600009.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... gi\|221322986 - gi\|221322986\|ref\|ZP_03604280.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus subtilis subs... FABG_BACSU - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Bacillus subtilis GN=fabG PE=3 SV=3 FABG_BACSU - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Bacillus subtilis (strain 168) GN=fabG PE=3 SV=3	270.0	[0..3]	[267..5]
gi\|110803752, gi... - gi\|110803752\|ref\|YP_698460.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens S...	269.0	[0..3]	[267..5]
gi\|158320488, gi... - gi\|158320488\|ref\|YP_001512995.1\| 3-oxoacyl-(acyl-carrier-protein) reductase [Alkaliphilus oremlandii...	269.0	[0..1]	[267..4]

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Predicted Domain #1

Region A:
Residues: [1-327]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARTVVLITGC SSGIGLHLAV RLASDPSQSF KVYATLRDLK TQGRLWEAAR ALACPPGSLE  60
   61 TLQLDVRDSK SVAAARERVT EGRVDVLVCN AGLGLLGPLE ALGEDAVASV LDVNVVGTVR 120
  121 MLQAFLPDMK RRGSGRVLVT GSVGGLMGLP FNDVYCASKF ALEGLCESLA VLLLPFGVHL 180
  181 SLIECGPVHT AFMEKVLGSP EEVLDRTDIH TFHRFYQYLA HSKQVFREAA QNPEEVAEVF 240
  241 LTALRAPKPT LRYFTTERFL PLLRMRLDDP SGSNYVTAMH REVFGDVPAK AEAGAEAGGG 300
  301 AGPGAEDEAG RSAVGDPELG DPPAAPQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.69897
Match:	1bhsA
Description:	HUMAN ESTROGENIC 17BETA-HYDROXYSTEROID DEHYDROGENASE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
retinol dehydrogenase activity	3.10587467349583	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
oxidoreductase activity	0.8894480857983	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	0.867909552357575	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.82673050487418	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.824879127880521	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
retinol binding	0.343379136183648	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	0.311551606659739	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	0.27189038644972	bayes_pls_golite062009
molecular transducer activity	0.220014544038474	bayes_pls_golite062009
signal transducer activity	0.220014544038474	bayes_pls_golite062009
channel activity	0.166857973838454	bayes_pls_golite062009
passive transmembrane transporter activity	0.166857973838454	bayes_pls_golite062009
substrate-specific channel activity	0.14195924411997	bayes_pls_golite062009
G-protein coupled receptor activity	0.135469305070471	bayes_pls_golite062009
nucleic acid binding	0.100470710829263	bayes_pls_golite062009
DNA binding	0.0824412435540247	bayes_pls_golite062009
NADPH:quinone reductase activity	0.0822919343613215	bayes_pls_golite062009
receptor activity	0.0665855982136239	bayes_pls_golite062009
ion channel activity	0.0487923057681532	bayes_pls_golite062009
ethanol binding	0.0448614072391299	bayes_pls_golite062009
gated channel activity	0.015794644474568	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: