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Protein Overview: COFA_DICDI, COFB...

General Information:
Name(s) found: COFB_DICDI [Swiss-Prot]
COFA_DICDI [Swiss-Prot]
Description(s) found:
Found 13 descriptions.
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  • Cofilin-1B OS=Dictyostelium discoideum GN=cofB PE=1 SV=1 [Swiss-Prot]
  • Cofilin-1A OS=Dictyostelium discoideum GN=cofA PE=1 SV=1 [Swiss-Prot]
    • Organism: Dictyostelium discoideum
    Length: 137 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    cell leading edge [TAS]
    actin cytoskeleton [IDA]
    ruffle [IDA]
    phagocytic vesicle [IDA][TAS]
    intracellular [IEA]
    Biological Process: biological_process [ND]
    response to bacterium [IEP]
    actin filament severing [IDA]
    cellular component movement [IMP]
    actin filament depolymerization [TAS]
    sporulation resulting in formation of a cellular spore [TAS]
    hyperosmotic response [IMP]
    actin filament bundle assembly [IMP]
    Molecular Function: actin filament binding [TAS]
    molecular_function [ND]
    actin monomer binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGIALAPN CVSTFNDLKL GRKYGGIIYR ISDDSKEIIV DSTLPAGCSF DEFTKCLPEN  60
   61 ECRYVVLDYQ YKEEGAQKSK ICFVAWCPDT ANIKKKMMAT SSKDSLRKAC VGIQVEIQGT 120
  121 DASEVKDSCF YEKCTKI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] PSI-BLAST 39.154902 Cofilin (actin depolymerizing factor, ADF)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  7.52071741004022 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.04859625643932 bayes_pls_golite062009
  • actin filament binding
    		•  5.45532510538573 bayes_pls_golite062009
  • protein binding
    		•  2.93027234013365 bayes_pls_golite062009
  • binding
    		•  2.84811181543046 bayes_pls_golite062009
  • protein kinase activity
    		•  2.04816578082974 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.67227267699496 bayes_pls_golite062009
  • kinase activity
    		•  1.55883505515498 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.47782133980448 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.4161727833926 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.3406661967545 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.693981553634544 bayes_pls_golite062009
  • signal transducer activity
    		•  0.693981553634544 bayes_pls_golite062009
  • transferase activity
    		•  0.591259446255369 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.482954032096802 bayes_pls_golite062009
  • structural molecule activity
    		•  0.391701411061931 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.270847057375333 bayes_pls_golite062009
  • actin monomer binding
    		•  0.224304003054399 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle