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Protein Overview: ci-PA

General Information:
Name(s) found: ci-PA / FBpp0088245 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene cubitus interruptus is referred to in FlyBase by the symbol Dmel\ci (CG2125, FBgn0004859). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:68334..77667. It has the cytological map location 102A1-102A3. There is experimental evidence that it has the molecular function</span>: protein binding; transcription activator activity. There is experimental evidence for 15 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; regulation of biological process; regulation of S phase of mitotic cell cycle; positive regulation of cellular biosynthetic process; regionalization; embryonic pattern specification; reproductive process in a multicellular organism; neuron differentiation; positive regulation of mitotic cell cycle; cuticle pattern formation; cell communication; positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; sensory organ development; genital disc pattern formation; open tracheal system development; system development; dendrite morphogenesis; multicellular organism reproduction. 192 alleles are reported. The phenotypes of these alleles are annotated with 50 unique terms, many of which group under: organ system; adult segment; adult mesothoracic segment; peripheral nervous system; nervous system; external compound sense organ; thoracic segment; spiracle; embryonic/larval dorsal branch; integumentary specialisation. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1397 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    cytoplasm [IDA]
    membrane [IDA]
    protein complex [IPI]
    Hedgehog signaling complex [IPI]
    Biological Process: spiracle morphogenesis, open tracheal system [IMP]
    blastoderm segmentation [TAS]
    epidermis development [IMP]
    segment polarity determination [IMP]
    smoothened signaling pathway [IEP][IMP][NAS][TAS]
    neuron development [IMP]
    positive regulation of transcription from RNA polymerase II promoter [IGI][IMP][TAS]
    regulation of transcription [TAS]
    regulation of mitotic cell cycle [IMP]
    dendrite morphogenesis [IMP]
    negative regulation of transcription from RNA polymerase II promoter [TAS]
    wing disc anterior/posterior pattern formation [IMP]
    eye morphogenesis [IMP]
    oogenesis [IEP]
    positive regulation of S phase of mitotic cell cycle [IMP]
    ovarian follicle cell development [TAS]
    labial disc development [IMP]
    genital disc anterior/posterior pattern formation [IEP]
    cuticle pattern formation [IMP]
    Molecular Function: nucleic acid binding [IEA]
    transcription factor activity [TAS]
    zinc ion binding [IEA]
    protein binding [IPI]
    specific RNA polymerase II transcription factor activity [NAS]
    transcription activator activity [IGI][TAS]
    transcription repressor activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAYALPTYF PLAYSELQFL ASRRAAAVAA AATVLPGSPC INQHHPTDVS SSVTVPSIIP  60
   61 TGGTSDSIKT SIQPQICNEN TLLGNAGHQH NHQPQHVHNI NVTGQPHDFH PAYRIPGYME 120
  121 QLYSLQRTNS ASSFHDPYVN CASAFHLAGL GLGSADFLGS RGLSSLGELH NAAVAAAAAG 180
  181 SLASTDFHFS VDGNRRLGSP RPPGGSIRAS ISRKRALSSS PYSDSFDINS MIRFSPNSLA 240
  241 TIMNGSRGSS AASGSYGHIS ATALNPMSHV HSTRLQQIQA HLLRASAGLL NPMTPQQVAA 300
  301 SGFSIGHMPT SASLRVNDVH PNLSDSHIQI TTSPTVTKDV SQVPAAAFSL KNLDDAREKK 360
  361 GPFKDVVPEQ PSSTSGGVAQ VEADSASSQL SDRCYNNVVN NITGIPGDVK VNSRLDEYIN 420
  421 CGSISIPSNE YDCANADTTD IKDEPGDFIE TNCHWRSCRI EFITQDELVK HINNDHIQTN 480
  481 KKAFVCRWED CTRGEKPFKA QYMLVVHMRR HTGEKPHKCT FEGCFKAYSR LENLKTHLRS 540
  541 HTGEKPYTCE YPGCSKAFSN ASDRAKHQNR THSNEKPYIC KAPGCTKRYT DPSSLRKHVK 600
  601 TVHGAEFYAN KKHKGLPLND ANSRLQQNNS RHNLQEHNID SSPCSEDSHL GKMLGTSSPS 660
  661 IKSESDISSS NHHLVNGVRA SDSLLTYSPD DLAENLNLDD GWNCDDDVDV ADLPIVLRAM 720
  721 VNIGNGNASA STIGGSVLAR QRFRGRLQTK GINSSTIMLC NIPESNRTFG ISELNQRITE 780
  781 LKMEPGTDAE IKIPKLPNTT IGGYTEDPLQ NQTSFRNTVS NKQGTVSGSI QGQFRRDSQN 840
  841 STASTYYGSM QSRRSSQSSQ VSSIPTMRPN PSCNSTASFY DPISPGCSRR SSQMSNGANC 900
  901 NSFTSTSGLP VLNKESNKSL NACINKPNIG VQGVGIYNSS LPPPPSSHLI ATNLKRLQRK 960
  961 DSEYHNFTSG RFSVPSYMHS LHIKNNKPVG ENEFDKAIAS NARRQTDPVP NINLDPLTNI1020
 1021 SRFSTTPHSF DINVGKTNNI ASSINKDNLR KDLFTVSIKA DMAMTSDQHP NERINLDEVE1080
 1081 ELILPDEMLQ YLNLVKDDTN HLEKEHQAVP VGSNVSETIA SNHYREQSNI YYTNKQILTP1140
 1141 PSNVDIQPNT TKFTVQDKFA MTAVGGSFSQ RELSTLAVPN EHGHAKCESF HHQSQKYMNT1200
 1201 DIGSKQQSAL PSAHQRQTEK SNYNQIIDSS MTSLPELNVD SIYPRNETEN IFKVHGDHDN1260
 1261 EIQCGIISQS QMSPSTNLNN DGQFSTVNMQ PITTSKLFPP EPQKIVCDTQ ASNTSVMHLD1320
 1321 TYQRTLEYVQ SCQNWMETNN TSTNQIQSLP GMPVNNTLFP DVSSSTHPYH GTNMVINDMT1380
 1381 TSLTSLLEEN RYLQMMQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] deduced N/A No confident structure predictions are available.
    2 View Details [186..326] deduced N/A No confident structure predictions are available.
    3 View Details [327..551] PSI-BLAST 52.69897 No description for 2i13A was found.
    4 View Details [552..650] FFAS03 4.66 No description for 2i13A was found.
    5 View Details [651..770] PSI-BLAST 20.39794 Designed zinc finger protein
    6 View Details [771..1011] deduced N/A No confident structure predictions are available.
    7 View Details [1012..1094] deduced N/A No confident structure predictions are available.
    8 View Details [1095..1314] PSI-BLAST 5.522879 Sec24
    9 View Details [1315..1397] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle