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Protein Overview: egl-4

General Information:
Name(s) found: egl-4 / CE37241 [WormBase]
Description(s) found:
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  • WBGene00001173 locus:egl-4 cGMP-dependent protein kinase egl-4 status:Confirmed UniProt:O76360 protein_id:CCD71863.1 [WormBase]
  • gi|71989393|ref|NP_001023223.1| EGg Laying defective family member (egl-4) [Caenorhabditis elegans] [NCBI NR]
  • gi|51536877|gb|AAU05567.1| Egg laying defective protein 4, isoform e [Caenorhabditis elegans] [NCBI NR]
  • Egg laying defective protein 4, isoform e [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE37241 WBGene00001173 locus:egl-4 status:Confirmed TR:Q688A9 protein_id:AAU05567.1 [wormpep150.fasta]
  • CE37241 WBGene00001173 locus:egl-4 status:Confirmed protein_id:AAU05567.1 [wormpep132.fasta]
  • 37241 WBGene00001173 locus:egl-4 status:Confirmed TR:Q688A9 protein_id:AAU05567.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE37241 WBGene00001173 locus:egl-4 status:Confirmed UniProt:Q688A9_CAEEL protein_id:AAU05567.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE37241 WBGene00001173 locus:egl-4 status:Confirmed UniProt:Q688A9_CAEEL protein_id:AAU05567.1| [wormORF-contam.fasta]
  • EGg Laying defective family member (egl-4) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE37241 WBGene00001173 locus:egl-4 status:Confirmed UniProt:O76360 protein_id:AAU05567.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE37241 WBGene00001173 locus:pkg-1 status:Confirmed UniProt:O76360 protein_id:CCD71863.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE37241 WBGene00001173 locus:egl-4 status:Confirmed UniProt:O76360 protein_id:CCD71863.1 [wormbase_c_elegans_ws234_and_mcherry_10-06-2012_reversed.fasta]
  • CE37241 WBGene00001173 locus:egl-4 status:Confirmed UniProt:O76360 protein_id:CCD71863.1 cGMP-dependent protein kinase egl-4 [wormpep246-ecoli-contam.fasta]
  • Isoform of O76360, Isoform e of cGMP-dependent protein kinase egl-4 OS=Caenorhabditis elegans GN=egl-4 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 743 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    cAMP-dependent protein kinase complex [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    cAMP-dependent protein kinase regulator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCWKFNPLKA LRVVEVQVGT RTFEAHELQK LIPQLEEAIS RKDAQLRQQQ TIVEGHIKRI  60
   61 SELEGEVTTL QRECDKLRSV LEQKAQSAAS PGGQPPSPSP RTDQLGNDLQ QKAVLPADGV 120
  121 QRAKKIAVSA EPTNFENKPA TLQHYNKTVG AKQMIRDAVQ KNDFLKQLAK EQIIELVNCM 180
  181 YEMRARAGQW VIQEGEPGDR LFVVAEGELQ VSREGALLGK MRAGTVMGEL AILYNCTRTA 240
  241 SVQALTDVQL WVLDRSVFQM ITQRLGMERH SQLMNFLTKV SIFQNLSEDR ISKMADVMDQ 300
  301 DYYDGGHYII RQGEKGDAFF VINSGQVKVT QQIEGETEPR EIRVLNQGDF FGERALLGEE 360
  361 VRTANIIAQA PGVEVLTLDR ESFGKLIGDL ESLKKDYGDK ERLAQVVREP PSPVKIVDDF 420
  421 REEFAQVTLK NVKRLATLGV GGFGRVELVC VNGDKAKTFA LKALKKKHIV DTRQQEHIFA 480
  481 ERNIMMETST DWIVKLYKTF RDQKFVYMLL EVCLGGELWT TLRDRGHFDD YTARFYVACV 540
  541 LEGLEYLHRK NIVYRDLKPE NCLLANTGYL KLVDFGFAKK LASGRKTWTF CGTPEYVSPE 600
  601 IILNKGHDQA ADYWALGIYI CELMLGRPPF QASDPMKTYT LILKGVDALE IPNRRIGKTA 660
  661 TALVKKLCRD NPGERLGSGS GGVNDIRKHR WFMGFDWEGL RSRTLKPPIL PKVSNPADVT 720
  721 NFDNYPPDND VPPDEFSGWD EGF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] PSI-BLAST 5.30103 Solution structure of the docking and dimerization domain of the type I alpha regulatory subunit of protein kinase A (RIalpha D/D)
    2 View Details [91..234] PSI-BLAST 44.69897 REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
    3 View Details [235..681] PSI-BLAST 42.39794 No description for 2ozoA was found.
    4 View Details [682..743] PSI-BLAST 85.522879 cAMP-dependent PK, catalytic subunit


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle