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View Structure Prediction Details

Protein: egl-4
Organism: Caenorhabditis elegans
Length: 743 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for egl-4.

Description E-value Query
Range
Subject
Range
egl-4 - cyclic-GMP-dependent protein kinase status:Confirmed UniProt:O76360 protein_id:AAD36954.1
554.0 [0..7] [743..44]

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Predicted Domain #1
Region A:
Residues: [1-90]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCWKFNPLKA LRVVEVQVGT RTFEAHELQK LIPQLEEAIS RKDAQLRQQQ TIVEGHIKRI  60
   61 SELEGEVTTL QRECDKLRSV LEQKAQSAAS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.30103
Match: 2ezwA
Description: Solution structure of the docking and dimerization domain of the type I alpha regulatory subunit of protein kinase A (RIalpha D/D)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [91-234]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGGQPPSPSP RTDQLGNDLQ QKAVLPADGV QRAKKIAVSA EPTNFENKPA TLQHYNKTVG  60
   61 AKQMIRDAVQ KNDFLKQLAK EQIIELVNCM YEMRARAGQW VIQEGEPGDR LFVVAEGELQ 120
  121 VSREGALLGK MRAGTVMGEL AILY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.69897
Match: 1rgsA
Description: REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [235-681]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NCTRTASVQA LTDVQLWVLD RSVFQMITQR LGMERHSQLM NFLTKVSIFQ NLSEDRISKM  60
   61 ADVMDQDYYD GGHYIIRQGE KGDAFFVINS GQVKVTQQIE GETEPREIRV LNQGDFFGER 120
  121 ALLGEEVRTA NIIAQAPGVE VLTLDRESFG KLIGDLESLK KDYGDKERLA QVVREPPSPV 180
  181 KIVDDFREEF AQVTLKNVKR LATLGVGGFG RVELVCVNGD KAKTFALKAL KKKHIVDTRQ 240
  241 QEHIFAERNI MMETSTDWIV KLYKTFRDQK FVYMLLEVCL GGELWTTLRD RGHFDDYTAR 300
  301 FYVACVLEGL EYLHRKNIVY RDLKPENCLL ANTGYLKLVD FGFAKKLASG RKTWTFCGTP 360
  361 EYVSPEIILN KGHDQAADYW ALGIYICELM LGRPPFQASD PMKTYTLILK GVDALEIPNR 420
  421 RIGKTATALV KKLCRDNPGE RLGSGSG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.39794
Match: 2ozoA
Description: No description for 2ozoA was found.

Predicted Domain #4
Region A:
Residues: [682-743]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVNDIRKHRW FMGFDWEGLR SRTLKPPILP KVSNPADVTN FDNYPPDNDV PPDEFSGWDE  60
   61 GF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.522879
Match: 1ctpE
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle