Protein Overview: let-413

General Information:
Name(s) found:	let-413 / CE37008 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00002632 locus:let-413 Protein lap1 status:Confirmed UniProt:O61967 protein_id:CCD70054.1 [WormBase] gi\|76803776\|sp\|O61967.3\|LAP1_CAEEL RecName: Full=Protein lap1; AltName: Full=Lethal protein 413 [NCBI NR] gi\|71991531\|ref\|NP_001023851.1\| LEThal family member (let-413) [Caenorhabditis elegans] [NCBI NR] gi\|50727055\|gb\|AAT81195.1\| Lethal protein 413, isoform b [Caenorhabditis elegans] [NCBI NR] Protein lap1 OS=Caenorhabditis elegans GN=let-413 PE=1 SV=3 [Swiss-Prot] Lethal protein 413, isoform b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas] CE37008 WBGene00002632 locus:let-413 status:Confirmed SW:O61967 protein_id:AAT81195.1 [wormpep150.fasta] 37008 WBGene00002632 locus:let-413 status:Partially_confirmed protein_id:AAT81195.1 [wormpep130-phg-ecoli-orf-rand.fasta] CE37008 WBGene00002632 locus:let-413 status:Partially_confirmed TR:Q6A580 protein_id:AAT81195.1 [wormpep132.fasta] 37008 WBGene00002632 locus:let-413 status:Confirmed SW:O61967 protein_id:AAT81195.1 [wormpep150-phg-orf-ecoli-rand.fasta] CE37008 WBGene00002632 locus:let-413 status:Confirmed TR:Q6A580 protein_id:AAT81195.1 [WormBase_C-elegans_na_01-20-2005_combined_reversed.fasta] CE37008 WBGene00002632 locus:let-413 status:Confirmed UniProt:O61967 protein_id:AAT81195.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE37008 WBGene00002632 locus:let-413 status:Confirmed UniProt:O61967 protein_id:AAT81195.1\| [wormORF-contam.fasta] Protein lap1 (Protein lethal-413) [nr-271106-contam.fasta] LEThal family member (let-413) [Caenorhabditis elegans] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE37008 WBGene00002632 locus:let-413 status:Confirmed UniProt:O61967 protein_id:CCD70054.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE37008 WBGene00002632 locus:let-413 status:Confirmed UniProt:O61967 protein_id:CCD70054.1 Protein lap1 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	699 amino acids
Gene Ontology:
Cellular Component:	basolateral plasma membrane [IDA]
Biological Process:	embryonic development [IMP] actin filament-based process [IMP] negative regulation of multicellular organism growth [IMP] hermaphrodite genitalia development [IMP] locomotory behavior [IMP] cell-cell junction assembly [IMP] embryonic development ending in birth or egg hatching [IMP ] reproduction [IMP]
Molecular Function:	protein binding [IEA][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAFFCLPMA CQRQVDSIDR SQSNLQAIPS DIFRFRKLED LNLTMNNIKE LDHRLFSLRH  60
   61 LRILDVSDNE LAVLPAEIGN LTQLIELNLN RNSIAKLPDT MQNCKLLTTL NLSSNPFTRL 120
  121 PETICECSSI TILSLNETSL TLLPSNIGSL TNLRVLEARD NLLRTIPLSI VELRKLEELD 180
  181 LGQNELEALP AEIGKLTSLR EFYVDINSLT SLPDSISGCR MLDQLDVSEN QIIRLPENLG 240
  241 RMPNLTDLNI SINEIIELPS SFGELKRLQM LKADRNSLHN LTSEIGKCQS LTELYLGQNF 300
  301 LTDLPDTIGD LRQLTTLNVD CNNLSDIPDT IGNCKSLTVL SLRQNILTEL PMTIGKCENL 360
  361 TVLDVASNKL PHLPFTVKVL YKLQALWLSE NQTQSILKLS ETRDDRKGIK VVTCYLLPQV 420
  421 DAIDGEGRSG SAQHNTDRGA FLGGPKVHFH DQADTTFEEN KEAEIHLGNF ERHNTPHPKT 480
  481 PKHKKGSIDG HMLPHEIDQP RQLSLVSNHR TSTSSFGESS NSINRDLADI RAQNGVREAT 540
  541 LSPEREERMA TSLSSLSNLA AGTQNMHTIR IQKDDTGKLG LSFAGGTSND PAPNSNGDSG 600
  601 LFVTKVTPGS AAYRCGLREG DKLIRANDVN MINASQDNAM EAIKKRETVE LVVLRRSPSP 660
  661 VSRTSEPSLN GSSHQLNHFD AGSPDSTMFV TSSTPVYAS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
signal transducer activity	2.54176035045352	bayes_pls_golite062009
molecular transducer activity	2.54176035045352	bayes_pls_golite062009
receptor activity	2.44108148686445	bayes_pls_golite062009
transmembrane receptor activity	2.25077658159974	bayes_pls_golite062009
protein kinase activity	1.61450095469422	bayes_pls_golite062009
G-protein coupled receptor activity	1.37462680876315	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.36168522830563	bayes_pls_golite062009
kinase activity	1.28067810202729	bayes_pls_golite062009
binding	1.23313855731605	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.875083054478353	bayes_pls_golite062009
protein binding	0.646159692466759	bayes_pls_golite062009
transferase activity	0.435331931559158	bayes_pls_golite062009
protein tyrosine kinase activity	0.231213253402712	bayes_pls_golite062009
nucleic acid binding	0.205944109094333	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
binding	2.6196222853442	bayes_pls_golite062009
protein binding	2.35875654816667	bayes_pls_golite062009
kinase activity	1.29833697558449	bayes_pls_golite062009
transporter activity	1.18978519116375	bayes_pls_golite062009
cytoskeletal protein binding	1.11584635608743	bayes_pls_golite062009
transmembrane transporter activity	1.07211582292329	bayes_pls_golite062009
signal transducer activity	1.06018756723145	bayes_pls_golite062009
molecular transducer activity	1.06018756723145	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.851396699088923	bayes_pls_golite062009
substrate-specific transporter activity	0.755223974149211	bayes_pls_golite062009
PDZ domain binding	0.71844819286977	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
protein kinase binding	0.54934142458843	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.549085929250683	bayes_pls_golite062009
kinase binding	0.541050170070789	bayes_pls_golite062009
receptor binding	0.359972518335054	bayes_pls_golite062009
transferase activity	0.325404241870749	bayes_pls_golite062009
beta-catenin binding	0.27594880120163	bayes_pls_golite062009
enzyme binding	0.265928259068924	bayes_pls_golite062009
actin binding	0.263747574646927	bayes_pls_golite062009
active transmembrane transporter activity	0.252733105474942	bayes_pls_golite062009
phosphatase binding	0.24515474358339	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.80

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..373]	PSI-BLAST	44.39794	No description for 2omxA was found.
2	View Details	[374..427]	PSI-BLAST	27.09691	Polygalacturonase inhibiting protein PGIP
3	View Details	[428..564]	deduced	N/A	No confident structure predictions are available.
4	View Details	[565..699]	PSI-BLAST	10.154902	Erbin

Protein Overview: let-413

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: