Protein Overview: MTO1

General Information:
Name(s) found:	MTO1 / YGL236C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|50593214\|ref\|NP_011278.2\| Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S r [NCBI NR] gi\|115502421\|sp\|P53070.2\|MTO1_YEAST RecName: Full=Mitochondrial translation optimization protein 1; Flags: Precursor [NCBI NR] Mitochondrial translation optimization protein 1 OS=Saccharomyces cerevisiae GN=MTO1 PE=1 SV=2 [Swiss-Prot] MTO1 Part of Mto1p/Mss1p complex with role in optimizing mitochondrial protein synthesis [mips] Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants [SGD] MTO1 SGDID:S0003205, Chr VII from 55796-53787, reverse complement, Verified ORF [10112005cervSGD.fasta] Mitochondrial protein required for respiration in paromomycin-resistant 15S rRNA mutants; forms a heterodimer complex with Mss1p that plays a role in optimizing mitochondrial protein synthesis [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] MTO1 SGDID:S000003205, Chr VII from 55796-53787, reverse complement, Verified ORF, "Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; Mto1p [Saccharom [nr-271106-contam.fasta] Mitochondrial translation optimization protein 1, mitochondrial precursor [nr-271106-contam.fasta] MTO1 SGDID:S000003205, Chr VII from 55796-53787, reverse complement, Verified ORF, "Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Mitochondrial translation optimization protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MTO1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MTO1 SGDID:S000003205, Chr VII from 55796-53787, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants" [yeast-030211-contam.fasta] MTO1 SGDID:S000003205, Chr VII from 55796-53787, Genome Release 64-2-1, reverse complement, Verified ORF, "Mitochondrial protein; forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants" [20141208_orf_trans.fasta] YGL236C SGDID:S000003205, Chr VII from 55796-53787, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	669 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA]
Biological Process:	response to drug [IMP] tRNA modification [IMP] translation [IMP ]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRVTTLASS CTSFPLQVLR RRLTISSLTS FQPTTKTQVV VIGAGHAGCE AAAASSRTGA  60
   61 HTTLITPSLT DIGKCSCNPS IGGVGKGILV KEIDALDGLM GKVTDLAGVQ FKMLNRSKGP 120
  121 AVWGPRAQID RELYKKYMQR ELSDKKAHPN LSLLQNKVAD LILYDPGCGH KVIKGVVLDD 180
  181 GTQVGADQVI ITTGTFLSAE IHIGDKRIAA GRIGEQPTYG ISNTLQNEVG FQLGRLKTGT 240
  241 PARLAKESID FSALEVQKGD ALPVPMSFLN ETVSVEPTKQ LDCFGTHTTP QMHDFLRNNL 300
  301 HQSIHIQDTT IKGPRYCPSI EAKILRFPDR SSHKIWLEPE GFNSDVIYPN GISNSMPEDV 360
  361 QLQMMRLIPG MANVEILQPA YGVEYDYVDP RQLKPSLETK LVDGLFLAGQ INGTTGYEEA 420
  421 AAQGIIAGIN AGLLSRQERE QLVLKRSEAY IGVLIDDLIN NGVIEPYRMF TSRSEFRISV 480
  481 RADNADFRLT PIGAQLGIIS PVRLSQYSRD KHLYDETIRA LQNFKLSSQK WSSLLQANIA 540
  541 PQAENRSAWE IFRFKDMDLH KLYECIPDLP INLLDIPMHV VTKINIQGKY EPYIVKQNQF 600
  601 VKAFQADENM LLPQDYDYRQ LPTLSTECKL LLNRVQPLTI GQARRIQGIT AAALFELYRV 660
  661 ARKPSQPVM

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	DMC1	MTO1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted