Protein Overview: IWR1

General Information:
Name(s) found:	IWR1 / YDL115C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|154199603\|ref\|NP_010168.4\| Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin; Iwr1p [Saccharomyces cerevisiae] [NCBI NR] gi\|150421583\|sp\|Q07532.2\|IWR1_YEAST RecName: Full=Putative transcription factor IWR1 [NCBI NR] Putative transcription factor IWR1 OS=Saccharomyces cerevisiae GN=IWR1 PE=1 SV=2 [Swiss-Prot] - IWR1 - Interacts With RNA Polymerase II [mips] Protein involved in transcription from polymerase II promoters; interacts with with most of the polymerase II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to the K1 killer toxin [SGD] IWR1 SGDID:S000002273, Chr IV from 255126-255045,254974-253995, reverse complement, Verified ORF, "Protein of unknown function, deletion causes hypersensitivity to the K1 killer toxin" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] IWR1 SGDID:S000002273, Chr IV from 255126-255045,254974-253995, reverse complement, Verified ORF, "Protein involved in transcription from polymerase II promoters; interacts with with most of the polymerase II subunits; nucleo-cytoplasmic shuttling protein [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] IWR1 SGDID:S000002273, Chr IV from 255126-255045,254974-253995, reverse complement, Verified ORF, "Protein involved in transcription from polymerase II promoters; interacts with with most of the polymerase II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to the K1 killer toxin" [SGDyeast.20101221.fasta] RNA polymerase II nuclear localization protein IWR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IWR1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] IWR1 SGDID:S000002273, Chr IV from 254974-253995,255126-255045, Genome Release 64-1-1, reverse complement, Verified ORF, "RNA polymerase II transport factor, conserved from yeast to humans; involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters, but not itself a transcription factor; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin" [yeast-030211-contam.fasta] IWR1 SGDID:S000002273, Chr IV from 254974-253995,255126-255045, Genome Release 64-2-1, reverse complement, Verified ORF, "RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress" [20141208_orf_trans.fasta] YDL115C SGDID:S000002273, Chr IV from 254974-253995,255126-255045, Genome Release 64-1-1, reverse complement, Verified ORF, "RNA polymerase II transport factor, conserved from yeast to humans; involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters, but not itself a transcription factor; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	353 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA] DNA-directed RNA polymerase II, holoenzyme [IPI]
Biological Process:	transcription from RNA polymerase II promoter [IC][IGI] meiosis [TAS]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTISTTTAP EFIRVKRRRD EDSVQALLID EGKRVKKQKF IFKLSKTVSS ESYQSEQESS  60
   61 TPLLKLAHED HRHFVLEQRK KSRRDSDDEK SQQRLAAEGS TVDDDGLPPE INQMVNDYLK 120
  121 LNKGVEKTER KKPSRKYFTG DSAKIASLPS LDYVFDIYHL EKIHDDEVAR YNNEKNIGFV 180
  181 KIIEHIDLAL DEESDPNEAR SDDEDSNDEN YYQNDYPEDE DDDRSILFGS EGEDIAALGE 240
  241 EIVIGVNKSR FSSWNDDKIQ GSNGYHDVEE EYGDLFNRLG GKSDVLKSIN SSNFIDLDGQ 300
  301 EGEIEISDNE DDSDEGDDIE YPRNEFFPTD VDDPLAHHRD RIFHQLQKKI NRS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	IWR1	Huh WK, et al. (2003)

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: IWR1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: