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Protein Overview: unc-22

General Information:
Name(s) found: unc-22 / CE40796 [WormBase]
Description(s) found:
Found 9 descriptions.
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  • WBGene00006759 locus:unc-22 status:Partially_confirmed UniProt:Q23551 protein_id:CAM35841.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 6629 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    A band [IDALink to PubMed article]
    proteinaceous extracellular matrix [IEALink to PubMed article]
    Biological Process: tRNA aminoacylation for protein translation [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    signal transduction [IEALink to PubMed article]
    locomotion [IMPLink to PubMed article]
    cell adhesion [IEALink to PubMed article]
    blood coagulation [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    translation [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    aminoacyl-tRNA ligase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQDFDSDSD SESQLDEIPS SGLTIPEERR RELLGQVGES DDEVSESISE LPSFAGGKPR  60
   61 RKTDSPPKQD DMFSRDTLLR KTTTSTKNES STVEEKTKLR KTVKKVDGEL DFKAMVKLKK 120
  121 VKKEEGGTTE KSGFPLDHAD STSSVLSQES RSRRGSNAPF AKDGLPEQPA NPFAQLKKVK 180
  181 SGAGGLEKSD SMASLKKLDL KKGKIDDNSD GAFKVQLKKV VKKEVKESTI SVKEKNGTES 240
  241 GIKTEFKMEK RERTTLQKYE KTDSDGSKKE DKPKKVSIAP VSTNKSSDDE PSTPRVRPQR 300
  301 IKVCMHHKEV EEKSTSEELK AKVAGRQVGQ KRNGAQKPEE PKNLLSQIQL KKVTKKAHDD 360
  361 TNELEGIKLK KVTTVPKHVA DDDSQSESES RRGSVFGELR RGSRAPRDSA DNSRRDSIRR 420
  421 SSIDMRRESV QEILEKTSTP LVPSGASGSA PKIVEVPENV TVVENETAIL TCKVSGSPAP 480
  481 TFRWFKGSRE VISGGRFKHI TDGKEHTVAL ALLKCRSQDE GPYTLTIENV HGTDSADVKL 540
  541 LVTSDNGLDF RAMLKHRESQ AGFQKDGEGG GAGGGGGEKK PMTEAERRQS LFPGKKVEKW 600
  601 DIPLPEKTVQ QQVDKICEWK CTYSRPNAKI RWYKDRKEIF SGGLKYKIVI EKNVCTLIIN 660
  661 NPEVDDTGKY TCEANGVPTH AQLTVLEPPM KYSFLNPLPN TQEIYRTKQA VLTCKVNTPR 720
  721 APLVWYRGSK AIQEGDPRFI IEKDAVGRCT LTIKEVEEDD QAEWTARITQ DVFSKVQVYV 780
  781 EEPRHTFVVP MKSQKVNESD LATLETDVND KDAEVVWWHD GKRIDIDGVK FKVESSNRKR 840
  841 RLIINGARIE DHGEYKCTTK DDRTMAQLIV DAKNKFIVAL KDTEVIEKDD VTLMCQTKDT 900
  901 KTPGIWFRNG KQISSMPGGK FETQSRNGTH TLKIGKIEMN EADVYEIDQA GLRGSCNVTV 960
  961 LEAEKRPILN WKPKKIEAKA GEPCVVKVPF QIKGTRRGDP KAQILKNGKP IDEEMRKLVE1020
 1021 VIIKDDVAEI VFKNPQLADT GKWALELGNS AGTALAPFEL FVKDKPKPPK GPLETKNVTA1080
 1081 EGLDLVWGTP DPDEGAPVKA YIIEMQEGRS GNWAKVGETK GTDFKVKDLK EHGEYKFRVK1140
 1141 ALNECGLSDP LTGESVLAKN PYGVPGKPKN MDAIDVDKDH CTLAWEPPEE DGGAPITGYI1200
 1201 IERREKSEKD WHQVGQTKPD CCELTDKKVV EDKEYLYRVK AVNKAGPGDP CDHGKPIKMK1260
 1261 AKKASPEFTG GGIKDLRLKV GETIKYDVPI SGEPLPECLW VVNGKPLKAV GRVKMSSERG1320
 1321 KHIMKIENAV RADSGKFTIT LKNSSGSCDS TATVTVVGRP TPPKGPLDIA DVCADGATLS1380
 1381 WNPPDDDGGD PLTGYIVEAQ DMDNKGKYIE VGKVDPNTTT LKVNGLRNKG NYKFRVKAVN1440
 1441 NEGESEPLSA DQYTQIKDPW DEPGKPGRPE ITDFDADRID IAWEPPHKDG GAPIEEYIVE1500
 1501 VRDPDTKEWK EVKRVPDTNA SISGLKEGKE YQFRVRAVNK AGPGQPSEPS EKQLAKPKFI1560
 1561 PAWLKHDNLK SITVKAGATV RWEVKIGGEP IPEVKWFKGN QQLENGIQLT IDTRKNEHTI1620
 1621 LCIPSAMRSD VGEYRLTVKN SHGADEEKAN LTVLDRPSKP NGPLEVSDVF EDNLNLSWKP1680
 1681 PDDDGGEPIE YYEVEKLDTA TGRWVPCAKV KDTKAHIDGL KKGQTYQFRV KAVNKEGASD1740
 1741 ALSTDKDTKA KNPYDEPGKT GTPDVVDWDA DRVSLEWEPP KSDGGAPITQ YVIEKKGKHG1800
 1801 RDWQECGKVS GDQTNAEILG LKEGEEYQFR VKAVNKAGPG EASDPSRKVV AKPRNLKPWI1860
 1861 DREAMKTITI KVGNDVEFDV PVRGEPPPKK EWIFNEKPVD DQKIRIESED YKTRFVLRGA1920
 1921 TRKHAGLYTL TATNASGSDK HSVEVIVLGK PSSPLGPLEV SNVYEDRADL EWKVPEDDGG1980
 1981 APIDHYEIEK MDLATGRWVP CGRSETTKTT VPNLQPGHEY KFRVRAVNKE GESDPLTTNT2040
 2041 AILAKNPYEV PGKVDKPELV DWDKDHVDLA WNAPDDGGAP IEAFVIEKKD KNGRWEEALV2100
 2101 VPGDQKTATV PNLKEGEEYQ FRISARNKAG TGDPSDPSDR VVAKPRNLAP RIHREDLSDT2160
 2161 TVKVGATLKF IVHIDGEPAP DVTWSFNGKG IGESKAQIEN EPYISRFALP KALRKQSGKY2220
 2221 TITATNINGT DSVTINIKVK SKPTKPKGPI EVTDVFEDRA TLDWKPPEDD GGEPIEFYEI2280
 2281 EKMNTKDGIW VPCGRSGDTH FTVDSLNKGD HYKFRVKAVN SEGPSDPLET ETDILAKNPF2340
 2341 DRPDRPGRPE PTDWDSDHVD LKWDPPLSDG GAPIEEYQIE KRTKYGRWEP AITVPGGQTT2400
 2401 ATVPDLTPNE EYEFRVVAVN KGGPSDPSDA SKAVIAKPRN LKPHIDRDAL KNLTIKAGQS2460
 2461 ISFDVPVSGE PAPTVTWHWP DNREIRNGGR VKLDNPEYQS KLVVKQMERG DSGTFTIKAV2520
 2521 NANGEDEATV KINVIDKPTS PNGPLDVSDV HGDHVTLNWR APDDDGGIPI ENYVIEKYDT2580
 2581 ASGRWVPAAK VAGDKTTAVV DGLIPGHEYK FRVAAVNAEG ESDPLETFGT TLAKDPFDKP2640
 2641 GKTNAPEITD WDKDHVDLEW KPPANDGGAP IEEYVVEMKD EFSPFWNDVA HVPAGQTNAT2700
 2701 VGNLKEGSKY EFRIRAKNKA GLGDPSDSAS AVAKARNVPP VIDRNSIQEI KVKAGQDFSL2760
 2761 NIPVSGEPTP TITWTFEGTP VESDDRMKLN NEDGKTKFHV KRALRSDTGT YIIKAENENG2820
 2821 TDTAEVKVTV LDHPSSPRGP LDVTNIVKDG CDLAWKEPED DGGAEISHYV IEKQDAATGR2880
 2881 WTACGESKDT NFHVDDLTQG HEYKFRVKAV NRHGDSDPLE AREAIIAKDP FDRADKPGTP2940
 2941 EIVDWDKDHA DLKWTPPADD GGAPIEGYLV EMRTPSGDWV PAVTVGAGEL TATVDGLKPG3000
 3001 QTYQFRVKAL NKAGESTPSD PSRTMVAKPR HLAPKINRDM FVAQRVKAGQ TLNFDVNVEG3060
 3061 EPAPKIEWFL NGSPLSSGGN THIDNNTDNN TKLTTKSTAR ADSGKYKIVA TNESGKDEHE3120
 3121 VDVNILDIPG APEGPLRHKD ITKESVVLKW DEPLDDGGSP ITNYVVEKQE DGGRWVPCGE3180
 3181 TSDTSLKVNK LSEGHEYKFR VKAVNRQGTS APLTSDHAIV AKNPFDEPDA PTDVTPVDWD3240
 3241 KDHVDLEWKP PANDGGAPID AYIVEKKDKF GDWVECARVD GKTTKATADN LTPGETYQFR3300
 3301 VKAVNKAGPG KPSDPTGNVV AKPRRMAPKL NLAGLLDLRI KAGTPIKLDI AFEGEPAPVA3360
 3361 KWKANDATID TGARADVTNT PTSSAIHIFS AVRGDTGVYK IIVENEHGKD TAQCNVTVLD3420
 3421 VPGTPEGPLK IDEIHKEGCT LNWKPPTDNG GTDVLHYIVE KMDTSRGTWQ EVGTFPDCTA3480
 3481 KVNKLVPGKE YAFRVKAVNL QGESKPLEAE EPIIAKNQFD VPDPVDKPEV TDWDKDRIDI3540
 3541 KWNPTANNGG APVTGYIVEK KEKGSAIWTE AGKTPGTTFS ADNLKPGVEY EFRVIAVNAA3600
 3601 GPSDPSDPTD PQITKARYLK PKILTASRKI KIKAGFTHNL EVDFIGAPDP TATWTVGDSG3660
 3661 AALAPELLVD AKSSTTSIFF PSAKRADSGN YKLKVKNELG EDEAIFEVIV QDRPSAPEGP3720
 3721 LEVSDVTKDS CVLNWKPPKD DGGAEISNYV VEKRDTKTNT WVPVSAFVTG TSITVPKLTE3780
 3781 GHEYEFRVMA ENTFGRSDSL NTDEPVLAKD PFGTPGKPGR PEIVDTDNDH IDIKWDPPRD3840
 3841 NGGSPVDHYD IERKDAKTGR WIKVNTSPVQ GTAFSDTRVQ KGHTYEYRVV AVNKAGPGQP3900
 3901 SDSSAAATAK PMHEAPKFDL DLDGKEFRVK AGEPLVITIP FTASPQPDIS WTKEGGKPLA3960
 3961 GVETTDSQTK LVIPSTRRSD SGPVKIKAVN PYGEAEANIK ITVIDKPGAP ENITYPAVSR4020
 4021 HTCTLNWDAP KDDGGAEIAG YKIEYQEVGS QIWDKVPGLI SGTAYTVRGL EHGQQYRFRI4080
 4081 RAENAVGLSD YCQGVPVVIK DPFDPPGAPS TPEITGYDTN QVSLAWNPPR DDGGSPILGY4140
 4141 VVERFEKRGG GDWAPVKMPM VKGTECIVPG LHENETYQFR VRAVNAAGHG EPSNGSEPVT4200
 4201 CRPYVEKPGA PDAPRVGKIT KNSAELTWNR PLRDGGAPID GYIVEKKKLG DNDWTRCNDK4260
 4261 PVRDTAFEVK NLGEKEEYEF RVIAVNSAGE GEPSKPSDLV LIEEQPGRPI FDINNLKDIT4320
 4321 VRAGETIQIR IPYAGGNPKP IIDLFNGNSP IFENERTVVD VNPGEIVITT TGSKRSDAGP4380
 4381 YKISATNKYG KDTCKLNVFV LDAPGKPTGP IRATDIQADA MTLSWRPPKD NGGDAITNYV4440
 4441 VEKRTPGGDW VTVGHPVGTT LRVRNLDANT PYEFRVRAEN QYGVGEPLET DDAIVAKNPF4500
 4501 DTPGAPGQPE AVETSEEAIT LQWTRPTSDG GAPIQGYVIE KREVGSTEWT KAAFGNILDT4560
 4561 KHRVTGLTPK KTYEFRVAAY NAAGQGEYSV NSVPITADNA PTRPKINMGM LTRDILAYAG4620
 4621 ERAKILVPFA ASPAPKVTFS KGENKISPTD PRVKVEYSDF LATLTIEKSE LTDGGLYFVE4680
 4681 LENSQGSDSA SIRLKVVDKP ASPQHIRVED IAPDCCTLYW MPPSSDGGSP ITNYIVEKLD4740
 4741 LRHSDGKWEK VSSFVRNLNY TVGGLIKDNR YRFRVRAETQ YGVSEPCELA DVVVAKYQFE4800
 4801 VPNQPEAPTV RDKDSTWAEL EWDPPRDGGS KIIGYQVQYR DTSSGRWINA KMDLSEQCHA4860
 4861 RVTGLRQNGE FEFRIIAKNA AGFSKPSPPS ERCQLKSRFG PPGPPIHVGA KSIGRNHCTI4920
 4921 TWMAPLEDGG SKITGYNVEI REYGSTLWTV ASDYNVREPE FTVDKLREFN DYEFRVVAIN4980
 4981 AAGKGIPSLP SGPIKIQESG GSRPQIVVKP EDTAQPYNRR AVFTCEAVGR PEPTARWLRN5040
 5041 GRELPESSRY RFEASDGVYK FTIKEVWDID AGEYTVEVSN PYGSDTATAN LVVQAPPVIE5100
 5101 KDVPNTILPS GDLVRLKIYF SGTAPFRHSL VLNREEIDMD HPTIRIVEFD DHILITIPAL5160
 5161 SVREAGRYEY TVSNDSGEAT TGFWLNVTGL PEAPQGPLHI SNIGPSTATL SWRPPVTDGG5220
 5221 SKITSYVVEK RDLSKDEWVT VTSNVKDMNY IVTGLFENHE YEFRVSAQNE NGIGAPLVSE5280
 5281 HPIIARLPFD PPTSPLNLEI VQVGGDYVTL SWQRPLSDGG GRLRGYIVEK QEEEHDEWFR5340
 5341 CNQNPSPPNN YNVPNLIDGR KYRYRVFAVN DAGLSDLAEL DQTLFQASGS GEGPKIVSPL5400
 5401 SDLNEEVGRC VTFECEISGS PRPEYRWFKG CKELVDTSKY TLINKGDKQV LIINDLTSDD5460
 5461 ADEYTCRATN SSGTRSTRAN LRIKTKPRVF IPPKYHGGYE AQKGETIELK IPYKAYPQGE5520
 5521 ARWTKDGEKI ENNSKFSITT DDKFATLRIS NASREDYGEY RVVVENSVGS DSGTVNVTVA5580
 5581 DVPEPPRFPI IENILDEAVI LSWKPPALDG GSLVTNYTIE KREAMGGSWS PCAKSRYTYT5640
 5641 TIEGLRAGKQ YEFRIIAENK HGQSKPCEPT APVLIPGDER KRRRGYDVDE QGKIVRGKGT5700
 5701 VSSNYDNYVF DIWKQYYPQP VEIKHDHVLD HYDIHEELGT GAFGVVHRVT ERATGNNFAA5760
 5761 KFVMTPHESD KETVRKEIQT MSVLRHPTLV NLHDAFEDDN EMVMIYEFMS GGELFEKVAD5820
 5821 EHNKMSEDEA VEYMRQVCKG LCHMHENNYV HLDLKPENIM FTTKRSNELK LIDFGLTAHL5880
 5881 DPKQSVKVTT GTAEFAAPEV AEGKPVGYYT DMWSVGVLSY ILLSGLSPFG GENDDETLRN5940
 5941 VKSCDWNMDD SAFSGISEDG KDFIRKLLLA DPNTRMTIHQ ALEHPWLTPG NAPGRDSQIP6000
 6001 SSRYTKIRDS IKTKYDAWPE PLPPLGRISN YSSLRKHRPQ EYSIRDAFWD RSEAQPRFIV6060
 6061 KPYGTEVGEG QSANFYCRVI ASSPPVVTWH KDDRELKQSV KYMKRYNGND YGLTINRVKG6120
 6121 DDKGEYTVRA KNSYGTKEEI VFLNVTRHSE PLKFEPLEPM KKAPSPPRVE EFKERRSAPF6180
 6181 FTFHLRNRLI QKNHQCKLTC SLQGNPNPTI EWMKDGHPVD EDRVQVSFRS GVCSLEIFNA6240
 6241 RVDDAGTYTV TATNDLGVDV SECVLTVQTK GGEPIPRVSS FRPRRAYDTL STGTDVERSH6300
 6301 SYADMRRRSL IRDVSPDVRS AADDLKTKIT NELPSFTAQL SDSETEVGGS AEFSAAVSGQ6360
 6361 PEPLIEWLHN GERISESDSR FRASYVAGKA TLRISDAKKS DEGQYLCRAS NSAGQEQTRA6420
 6421 TLTVKGDQPL LNGHAGQAVE SELRVTKHLG GEIVNNGESV TFEARVQGTP EEVLWMRNGQ6480
 6481 ELTNGDKTSI SQDGETLSFT INSADASDAG HYQLEVRSKG TNLVSVASLV VVGEKADPPV6540
 6541 TRLPSSVSAP LGGSTAFTIE FENVEGLTVQ WFRGSEKIEK NERVKSVKTG NTFKLDIKNV6600
 6601 EQDDDGIYVA KVVKEKKAIA KYAAALLLV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle