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Protein Overview: HEM3_ARATH

General Information:
Name(s) found: HEM3_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|313838|emb|CAA52061.1| hydroxymethylbilane synthase [Arabidopsis thaliana] [NCBI NR]
  • gi|313150|emb|CAA51941.1| hydroxymethylbilane synthase [Arabidopsis thaliana] [NCBI NR]
  • gi|2495179|sp|Q43316.1|HEM3_ARATH RecName: Full=Porphobilinogen deaminase, chloroplastic; Short=PBG; AltName: Full=Pre-uroporphyrinogen synthase; AltName: Full=Hydroxymethylbilane synthase; Short=HMBS; Flags: Precursor [NCBI NR]
  • gi|21689853|gb|AAM67570.1| putative hydroxymethylbilane synthase [Arabidopsis thaliana] [NCBI NR]
  • gi|17979402|gb|AAL49926.1| putative hydroxymethylbilane synthase [Arabidopsis thaliana] [NCBI NR]
  • gi|16930521|gb|AAL31946.1|AF419614_1 AT5g08280/F8L15_10 [Arabidopsis thaliana] [NCBI NR]
  • gi|15241573|ref|NP_196445.1| HEMC (HYDROXYMETHYLBILANE SYNTHASE); hydroxymethylbilane synthase [Arabidopsis thaliana] [NCBI NR]
  • pir||S50762 hydroxymethylbilane synthase (EC 4.3.1.8) precursor - Arabidopsis thaliana [NCBI NR]
  • gi|10178270|emb|CAC08328.1| hydroxymethylbilane synthase [Arabidopsis thaliana] [NCBI NR]
  • Porphobilinogen deaminase, chloroplastic OS=Arabidopsis thaliana GN=HEMC PE=1 SV=1 [Swiss-Prot]
  • (Q43316) Porphobilinogen deaminase, chloroplast precursor (EC 2.5.1.61) (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) [athaliana3702.FASTAC.txt]
  • putative hydroxymethylbilane synthase [Arabidopsis thaliana]gi|17979402|gb|AAL49926.1| putative hydroxymethylbilane synthase [Arabidopsis thaliana]gi|10178270|emb|CAC08328.1| hydroxymethylbilane synthase [Arabidopsis thaliana]gi|313838|emb|CAA52061.1| [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Porphobilinogen deaminase, chloroplast precursor [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: HEMC | HEMC (HYDROXYMETHYLBILANE SYNTHASE); hydroxymethylbilane synthase | chr5:2663764-2665597 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • hydroxymethylbilane synthase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • putative hydroxymethylbilane synthase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • AT5g08280/F8L15_10 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • Porphobilinogen deaminase, chloroplast precursor (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) [nr-271106-contam.fasta]
  • | Symbols: HEMC | hydroxymethylbilane synthase | chr5:2663763-2665596 REVERSE LENGTH=382 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 382 amino acids

    Gene Ontology:
    Cellular Component: chloroplast stroma [IDA]
    chloroplast [IDA]
    apoplast [IDA]
    chloroplast envelope [IDA]
    Biological Process: chlorophyll biosynthetic process [TAS]
    porphyrin biosynthetic process [TAS]
    defense response to bacterium [IEP]
    Molecular Function: hydroxymethylbilane synthase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDIASSSLSQ AHKVVLTRQP SSRVNTCSLG SVSAIGFSLP QISSPALGKC RRKQSSSGFV  60
   61 KACVAVEQKT RTAIIRIGTR GSPLALAQAY ETREKLKKKH PELVEDGAIH IEIIKTTGDK 120
  121 ILSQPLADIG GKGLFTKEID EALINGHIDI AVHSMKDVPT YLPEKTILPC NLPREDVRDA 180
  181 FICLTAATLA ELPAGSVVGT ASLRRKSQIL HKYPALHVEE NFRGNVQTRL SKLQGGKVQA 240
  241 TLLALAGLKR LSMTENVASI LSLDEMLPAV AQGAIGIACR TDDDKMATYL ASLNHEETRL 300
  301 AISCERAFLE TLDGSCRTPI AGYASKDEEG NCIFRGLVAS PDGTKVLETS RKGPYVYEDM 360
  361 VKMGKDAGQE LLSRAGPGFF GN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..382] PSI-BLAST 129.0 REDUCED FORM SELENOMETHIONINE-LABELLED HYDROXYMETHYLBILANE SYNTHASE DETERMINED BY MAD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.22743737647397 bayes_pls_golite062009
  • DNA binding
    		•  2.86883926687971 bayes_pls_golite062009
  • transcription factor activity
    		•  2.7948293378347 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.66637887681284 bayes_pls_golite062009
  • binding
    		•  2.63182502368928 bayes_pls_golite062009
  • hydroxymethylbilane synthase activity
    		•  2.03196514141563 bayes_pls_golite062009
  • catalytic activity
    		•  0.674312982669564 bayes_pls_golite062009
  • transcription activator activity
    		•  0.050905489018976 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle