Protein Overview: zag-1

General Information:
Name(s) found:	zag-1 / CE34546 [WormBase]
Description(s) found: Found 20 descriptions. SHOW ALL	WBGene00006970 locus:zag-1 Zinc finger E-box-binding homeobox protein zag-1 status:Confirmed UniProt:G5EBU4 protein_id:CCD70186.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	596 amino acids
Gene Ontology:
Cellular Component:	nucleus [IC][IEA] intracellular [IEA]
Biological Process:	locomotion [IMP] negative regulation of transcription [TAS] axon guidance [IMP] regulation of transcription, DNA-dependent [IEA] positive regulation of axon extension [IMP]
Molecular Function:	nucleic acid binding [IEA] transcription factor activity [IEA] zinc ion binding [IEA] sequence-specific DNA binding [IEA] transcription repressor activity [ISS][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDIAEAMPT TASSLPSDEA LRKFKCPECT KAFKFKHHLK EHIRIHSGEK PFECQQCHKR  60
   61 FSHSGSYSSH MSSKKCVQQA SPSMVTPFNP YQLMMYRNIM LQLQTPQVSF LPSTAANNMD 120
  121 YMSLLQANLF QSLENGTSPT PTQEPSAPAS PEPKIEVVDE PEVSSEVKTE VKTEVKTEDS 180
  181 VPEESITPAV SMSLSPAPEQ NGNESMNNGG SGSDGKSSPD WRPLRSRSFL NDSQVAVLQN 240
  241 HFKRNPFPSK YELSAVAEQI GVNKRVVQVW FQNTRAKERR SNRLPSMPRG SVASAAAAAA 300
  301 TSPTVWQTPV QLMAAWASQF SNGNNSLTAS QDERNNENTD EVMDHDGLKD GKETPLDLTL 360
  361 STDDTEPEWS PEKLIGFLDQ TGGVIQELLR QAGNGFVTNQ EDEEEKPIKA EESPVSSGSS 420
  421 SIWPSFIGQY PSILDSASLS VLEKALDQQK SSEDDASSLC SNESKLLKFP TTPLKEEEGL 480
  481 FSCDQCDKVF GKQSSLARHK YEHSGQRPYK CDICEKAFKH KHHLTEHKRL HSGEKPFQCD 540
  541 KCLKRFSHSG SYSQHMNHRY SYCKPYREQP ASPSDVLNGG SVTVSPSSSN TPPPST

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..128]	PSI-BLAST	4.045757	No description for 2dlkA was found.
2	View Details	[129..196]	deduced	N/A	No confident structure predictions are available.
3	View Details	[197..349]	PSI-BLAST	17.69897	Transcription factor IIIA, TFIIIA
4	View Details	[350..430]	FFAS03	0.983	SOLUTION STRUCTURE OF THE MU NER PROTEIN BY MULTIDIMENSIONAL NMR
5	View Details	[431..596]	PSI-BLAST	57.154902	No description for 2i13A was found.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
transcription regulator activity	3.14649486810497	bayes_pls_golite062009
DNA binding	2.89992872665011	bayes_pls_golite062009
nucleic acid binding	2.66588130528088	bayes_pls_golite062009
transcription factor activity	1.97913234583912	bayes_pls_golite062009
binding	1.7678140110688	bayes_pls_golite062009
transcription repressor activity	1.56441586442357	bayes_pls_golite062009
protein binding	1.33682539095771	bayes_pls_golite062009
catalytic activity	0.616333600617445	bayes_pls_golite062009
transcription activator activity	0.35578487491271	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.29294316958168	bayes_pls_golite062009

2

No functions predicted.

3

Term	Confidence	Notes
transcription regulator activity	3.14649486810497	bayes_pls_golite062009
DNA binding	2.89992872665011	bayes_pls_golite062009
nucleic acid binding	2.66588130528088	bayes_pls_golite062009
transcription factor activity	1.97913234583912	bayes_pls_golite062009
binding	1.7678140110688	bayes_pls_golite062009
transcription repressor activity	1.56441586442357	bayes_pls_golite062009
protein binding	1.33682539095771	bayes_pls_golite062009
catalytic activity	0.616333600617445	bayes_pls_golite062009
transcription activator activity	0.35578487491271	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.29294316958168	bayes_pls_golite062009

4

Term	Confidence	Notes
DNA binding	3.50333148278009	bayes_pls_golite062009
transcription regulator activity	3.22435490927648	bayes_pls_golite062009
nucleic acid binding	3.13941403740118	bayes_pls_golite062009
binding	2.1596228032617	bayes_pls_golite062009
transcription factor activity	2.10376028888832	bayes_pls_golite062009
transcription repressor activity	1.47303242361831	bayes_pls_golite062009
protein binding	0.835527357717776	bayes_pls_golite062009
catalytic activity	0.416161499675821	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.0407275201491086	bayes_pls_golite062009

5

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle