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Protein Overview: lin-40

General Information:
Name(s) found: lin-40 / CE33330 [WormBase]
Description(s) found:
Found 16 descriptions.
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  • WBGene00003025 locus:lin-40 status:Partially_confirmed UniProt:Q86S27 protein_id:CCD74257.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 756 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: negative regulation of vulval development [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    hermaphrodite genitalia development [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    oviposition [IMPLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSSLSSTS TRVTYAVGDF VYFDDTSATD APYQIRKIEE LVKTEKGGVD ARCVVYLRRR  60
   61 DIPQHLLKIA DQAQRRFDNY YEVDKKKPEN FTTKGFIVVN GASEAAPEAA PEATEASAET 120
  121 SETKVKEDTD DVAEKMEEDE ECPAPVGQGR TSSTEEPSAS DAPAATAKDK KEEKEAKENA 180
  181 KNLKETAEAE ATKLIDWGDG GLPLGVDKLT PDQRLKLRQH EIFMTRQSEI LPAAAIRGKC 240
  241 RVVLLGDGEE AQNYLPLDDT FYHSLVYDPN AQTLLADKGA IRVGEKYQAV VDEWMEPADR 300
  301 EAKEAKVLAE KVKKEEEEAK LKAEAEEDTE NDGLTIAEDE EMPELKNEEK EETKVEEEAT 360
  361 TTDSEGEVGE VLVWHPHHAL TDRDIDQYMI VARSVGLFAR AIDGASAPKL PTLQLAAAFA 420
  421 SRDVTIFHAH AILHQANYDV GQAVKYLVPV ASRDTYPCQV DDSSGLQTKT LGGPILCRDQ 480
  481 LEEWSTPEMN LFEDALDKVG KDFNEIRAEY LPWKSIRDIV EYYYLMKASN RYTDRKKNKP 540
  541 SAGGGSSTTT DEKFTNIYIP PFNKPIAASI LPYNTSQTTL MNNDNPCENC GTLDALNWYQ 600
  601 WGGVGDKKVL CSTCWIQWKK FAGLNQKHEL ERFDKTRPPP VEPVAPTPAA SNGTPASQKA 660
  661 AATAAVNTLT PQQQQQQRAA AANMLMTLNS GDKQNLLNVA KEALARGQIT QEQFLQLQKN 720
  721 FAQKIQAQIQ QQIQQQQQRQ AQTTPQVVAT PRVRIG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] MSA 2.03095 View MSA. No confident structure predictions are available.
    2 View Details [169..275] deduced N/A No confident structure predictions are available.
    3 View Details [276..410] Pfam 11.49485 No description for PF01448.15 was found. No confident structure predictions are available.
    4 View Details [411..464] deduced N/A No confident structure predictions are available.
    5 View Details [465..546] PSI-BLAST 15.0 Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein
    6 View Details [547..651] PSI-BLAST 6.522879 Erythroid transcription factor GATA-1
    7 View Details [652..756] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  0.334577365229545 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0696342306231097 bayes_pls_golite062009
    6
    Term Confidence Notes
  • binding
    		•  0.270879137859077 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle