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View Structure Prediction Details

Protein: lin-40
Organism: Caenorhabditis elegans
Length: 756 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lin-40.

Description E-value Query
Range
Subject
Range
lin-40 - status:Partially_confirmed UniProt:Q86S28 protein_id:AAO25984.1
548.0 [0..12] [754..12]

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Predicted Domain #1
Region A:
Residues: [1-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSSLSSTS TRVTYAVGDF VYFDDTSATD APYQIRKIEE LVKTEKGGVD ARCVVYLRRR  60
   61 DIPQHLLKIA DQAQRRFDNY YEVDKKKPEN FTTKGFIVVN GASEAAPEAA PEATEASAET 120
  121 SETKVKEDTD DVAEKMEEDE ECPAPVGQGR TSSTEEPSAS DAPAATAK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [169-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKKEEKEAKE NAKNLKETAE AEATKLIDWG DGGLPLGVDK LTPDQRLKLR QHEIFMTRQS  60
   61 EILPAAAIRG KCRVVLLGDG EEAQNYLPLD DTFYHSLVYD PNAQTLL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [276-410]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADKGAIRVGE KYQAVVDEWM EPADREAKEA KVLAEKVKKE EEEAKLKAEA EEDTENDGLT  60
   61 IAEDEEMPEL KNEEKEETKV EEEATTTDSE GEVGEVLVWH PHHALTDRDI DQYMIVARSV 120
  121 GLFARAIDGA SAPKL

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 11.49485
Match: PF01448.15
Description: No description for PF01448.15 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [411-464]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTLQLAAAFA SRDVTIFHAH AILHQANYDV GQAVKYLVPV ASRDTYPCQV DDSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [465-546]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLQTKTLGGP ILCRDQLEEW STPEMNLFED ALDKVGKDFN EIRAEYLPWK SIRDIVEYYY  60
   61 LMKASNRYTD RKKNKPSAGG GS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 2crgA
Description: Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.334577365229545 bayes_pls_golite062009
transcription regulator activity 0.0696342306231097 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [547-651]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STTTDEKFTN IYIPPFNKPI AASILPYNTS QTTLMNNDNP CENCGTLDAL NWYQWGGVGD  60
   61 KKVLCSTCWI QWKKFAGLNQ KHELERFDKT RPPPVEPVAP TPAAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.522879
Match: 4gatA
Description: Erythroid transcription factor GATA-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.270879137859077 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [652-756]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGTPASQKAA ATAAVNTLTP QQQQQQRAAA ANMLMTLNSG DKQNLLNVAK EALARGQITQ  60
   61 EQFLQLQKNF AQKIQAQIQQ QIQQQQQRQA QTTPQVVATP RVRIG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle