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Protein Overview: pde-3

General Information:
Name(s) found: pde-3 / CE32847 [WormBase]
Description(s) found:
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  • WBGene00008443 locus:pde-3 Probable 3',5'-cyclic phosphodiesterase pde-3 status:Partially_confirmed UniProt:Q8I0P7 protein_id:CAB07570.3 [WormBase]
  • gi|32564105|ref|NP_497084.2| PhosphoDiEsterase family member (pde-3) [Caenorhabditis elegans] [NCBI NR]
  • gi|26985918|emb|CAC35868.2| C. elegans protein E01F3.1a, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|26985840|emb|CAB07570.3| C. elegans protein E01F3.1a, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • [wormpep104.fasta]
  • CE32847 WBGene00008443 locus:pde-3 3'5'-cyclic nucleotide phosphodiesterases status:Partially_confirmed SW:Q8I0P7 protein_id:CAC35868.2 [wormpep150.fasta]
  • 32847 WBGene00008443 3'5'-cyclic nucleotide phosphodiesterases status:Partially_confirmed TR:Q9BH44 protein_id:CAC35868.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • 3'5'-cyclic nucleotide phosphodiesterase family member (54.2 kD) (2P237) [Caenorhabditis elegans]gi|26985840|emb|CAB07570.3| Hypothetical protein E01F3.1a [Caenorhabditis elegans]gi|26985918|emb|CAC35868.2| Hypothetical protein E01F3.1a [Caenorhabditis [nrdb_11152004_Chlamydomonas]
  • CE32847 WBGene00008443 3'5'-cyclic nucleotide phosphodiesterases status:Partially_confirmed TR:Q9BH44 protein_id:CAC35868.2 [wormpep132.fasta]
  • 32847 WBGene00008443 locus:pde-3 3'5'-cyclic nucleotide phosphodiesterases status:Partially_confirmed SW:Q8I0P7 protein_id:CAC35868.2 [wormpep150-phg-orf-ecoli-rand.fasta]
  • 3'5'-cyclic nucleotide phosphodiesterases status:Partially_confirmed TR:Q9BH44 protein_id:CAC35868.2 [wormpep115.fasta.reversed]
  • CE32847 WBGene00008443 locus:pde-3 3'5'-cyclic nucleotide phosphodiesterases status:Partially_confirmed UniProt:Q8I0P7 protein_id:CAC35868.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE32847 WBGene00008443 locus:pde-3 3'5'-cyclic nucleotide phosphodiesterases status:Partially_confirmed UniProt:Q8I0P7 protein_id:CAC35868.2| [wormORF-contam.fasta]
  • Hypothetical protein E01F3.1a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • PhosphoDiEsterase family member (pde-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE32847 WBGene00008443 locus:pde-3 3'5'-cyclic nucleotide phosphodiesterases status:Partially_confirmed UniProt:Q8I0P7 protein_id:CAB07570.3 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE32847 WBGene00008443 locus:pde-3 status:Partially_confirmed UniProt:Q8I0P7 protein_id:CAB07570.3 Probable 3',5'-cyclic phosphodiesterase pde-3 [wormpep246-ecoli-contam.fasta]
  • Isoform of Q8I0P7, Isoform a of Probable 3',5'-cyclic phosphodiesterase pde-3 OS=Caenorhabditis elegans GN=pde-3 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 472 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: signal transduction [IEALink to PubMed article]
    Molecular Function: catalytic activity [IEALink to PubMed article]
    3',5'-cyclic-nucleotide phosphodiesterase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSKVFKSKK NFCSYWKTEA SPSNNNEHET PVDLLRKISV SRKESGTHVD TVVTTIDGQR  60
   61 YDTRELDTDP DLAETAVWSF PIFQMSRKHP QTILSRLTYN IFQQAELFRI FKVSPIKFFN 120
  121 FFHALEKGYW EIPYHNRIHA ADVLHGCYYL SAHPVRSTFL TPKTPDSVLT PPHPHHQHSS 180
  181 IMSQLSTLEL MALFTAAAMH DYDHPGRTNA FLVQVEDKKA ILYNDRSVLE NHHAAESWKL 240
  241 LNKPENHFIE NLDPAEMKRF RYLVLEYILA TDLKQHFEII MTFTERLTEI DVQVETDRLL 300
  301 IGKLLIKMAD INSPTKPYGL HRQWTDRICE EFYEQGDDER RRGLPITPYM DRGDAQVAKL 360
  361 QDSFIAHVVS PLATAMNECG LLPILPGLDT SELIINMEHN HRKWKEQIEL ENGGSYEAQI 420
  421 TCNGGTAVNG VIEEESASTS DSPDPRRDSP LDSDLSQVPF TICCSIAEEE YV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..67] MSA 2.189994 View MSA. No confident structure predictions are available.
    2 View Details [68..472] PSI-BLAST 91.045757 CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B In COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  2.9145758096876 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  2.80645470666968 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  2.4031735631386 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  2.2478354053668 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.431522480252729 bayes_pls_golite062009
  • binding
    		•  0.0840884387362641 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.0469692618690128 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle