YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: pde-3
Organism: Caenorhabditis elegans
Length: 472 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pde-3.

Description E-value Query
Range
Subject
Range
gi|114600121 - gi|114600121|ref|XP_001138439.1| PREDICTED: similar to cyclic AMP phosphodiesterase isoform 6 [Pan t...
434.0 [0..3] [469..334]

Back

Predicted Domain #1
Region A:
Residues: [1-67]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSKVFKSKK NFCSYWKTEA SPSNNNEHET PVDLLRKISV SRKESGTHVD TVVTTIDGQR  60
   61 YDTRELD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [68-472]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDPDLAETAV WSFPIFQMSR KHPQTILSRL TYNIFQQAEL FRIFKVSPIK FFNFFHALEK  60
   61 GYWEIPYHNR IHAADVLHGC YYLSAHPVRS TFLTPKTPDS VLTPPHPHHQ HSSIMSQLST 120
  121 LELMALFTAA AMHDYDHPGR TNAFLVQVED KKAILYNDRS VLENHHAAES WKLLNKPENH 180
  181 FIENLDPAEM KRFRYLVLEY ILATDLKQHF EIIMTFTERL TEIDVQVETD RLLIGKLLIK 240
  241 MADINSPTKP YGLHRQWTDR ICEEFYEQGD DERRRGLPIT PYMDRGDAQV AKLQDSFIAH 300
  301 VVSPLATAMN ECGLLPILPG LDTSELIINM EHNHRKWKEQ IELENGGSYE AQITCNGGTA 360
  361 VNGVIEEESA STSDSPDPRR DSPLDSDLSQ VPFTICCSIA EEEYV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.045757
Match: 1so2A
Description: CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B In COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclic-nucleotide phosphodiesterase activity 2.9145758096876 bayes_pls_golite062009
3',5'-cyclic-nucleotide phosphodiesterase activity 2.80645470666968 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 2.4031735631386 bayes_pls_golite062009
phosphoric diester hydrolase activity 2.2478354053668 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.431522480252729 bayes_pls_golite062009
binding 0.0840884387362641 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.0469692618690128 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle