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Protein Overview: skn-1

General Information:
Name(s) found: skn-1 / CE31239 [WormBase]
Description(s) found:
Found 19 descriptions.
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  • WBGene00004804 locus:skn-1 Protein skinhead-1 status:Confirmed UniProt:P34707 protein_id:CCD62214.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 533 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article][IEALink to PubMed article]
    Biological Process: response to oxidative stress [IEPLink to PubMed article][IMPLink to PubMed article]
    response to heat [IEPLink to PubMed article][IMPLink to PubMed article]
    determination of adult lifespan [IMPLink to PubMed article]
    embryonic pattern specification [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    cell fate specification [IMPLink to PubMed article]
    mesendoderm development [TASLink to PubMed article]
    response to herbicide [IEPLink to PubMed article][IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    RNA polymerase II transcription factor activity, enhancer binding [IDALink to PubMed article]
    double-stranded DNA binding [IDALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    protein dimerization activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTDSNNRNF DEVNHQHQQE QDFNGQSKYD YPQFNRPMGL RWRDDQRMME YFMSNGPVET  60
   61 VPVMPILTEH PPASPFGRGP STERPTTSSR YEYSSPSLED IDLIDVLWRS DIAGEKGTRQ 120
  121 VAPADQYECD LQTLTEKSTV APLTAEENAR YEDLSKGFYN GFFESFNNNQ YQQKHQQQQR 180
  181 EQIKTPTLEH PTQKAELEDD LFDEDLAQLF EDVSREEGQL NQLFDNKQQH PVINNVSLSE 240
  241 GIVYNQANLT EMQEMRDSCN QVSISTIPTT STAQPETLFN VTDSQTVEQW LPTEVVPNDV 300
  301 FPTSNYAYIG MQNDSLQAVV SNGQIDYDHS YQSTGQTPLS PLIIGSSGRQ QQTQTSPGSV 360
  361 TVTATATQSL FDPYHSQRHS FSDCTTDSSS TCSRLSSESP RYTSESSTGT HESRFYGKLA 420
  421 PSSGSRYQRS SSPRSSQSSI KIARVVPLAS GQRKRGRQSK DEQLASDNEL PVSAFQISEM 480
  481 SLSELQQVLK NESLSEYQRQ LIRKIRRRGK NKVAARTCRQ RRTDRHDKMS HYI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] deduced N/A No confident structure predictions are available.
    2 View Details [94..248] MSA 2.159996 View MSA. No confident structure predictions are available.
    3 View Details [249..449] MSA 4.165982 View MSA. No confident structure predictions are available.
    4 View Details [450..533] PSI-BLAST 19.221849 Skn-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56528092116191 bayes_pls_golite062009
  • DNA binding
    		•  4.39236205038451 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.27517034548789 bayes_pls_golite062009
  • transcription factor activity
    		•  3.86034396858961 bayes_pls_golite062009
  • binding
    		•  3.28937567198027 bayes_pls_golite062009
  • protein binding
    		•  2.82801305666365 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.80824533696213 bayes_pls_golite062009
  • transcription activator activity
    		•  2.80670414213103 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  1.87549895714075 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.4553301455216 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.12585390480455 bayes_pls_golite062009
  • transcription factor binding
    		•  0.495155180229128 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle