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Protein Overview: nhr-66

General Information:
Name(s) found: nhr-66 / CE31062 [WormBase]
Description(s) found:
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  • WBGene00003656 locus:nhr-66 status:Confirmed UniProt:Q8MXH0 protein_id:CCD63563.1 [WormBase]
  • gi|25148057|ref|NP_741464.1| Nuclear Hormone Receptor family member (nhr-66) [Caenorhabditis elegans] [NCBI NR]
  • gi|21450530|gb|AAM54167.1|AF047660_5 Nuclear hormone receptor family protein 66, isoform b [Caenorhabditis elegans] [NCBI NR]
  • [wormpep88.fasta]
  • CE31062 WBGene00003656 locus:nhr-66 status:Confirmed TR:Q8MXH0 protein_id:AAM54167.1 [wormpep150.fasta]
  • 31062 WBGene00003656 locus:nhr-66 status:Partially_confirmed TR:Q8MXH0 protein_id:AAM54167.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • nuclear Hormone Receptor (nhr-66) [Caenorhabditis elegans]gi|21450530|gb|AAM54167.1| Nuclear hormone receptor family protein 66, isoform b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE31062 WBGene00003656 locus:nhr-66 status:Partially_confirmed TR:Q8MXH0 protein_id:AAM54167.1 [wormpep132.fasta]
  • 31062 WBGene00003656 locus:nhr-66 status:Confirmed TR:Q8MXH0 protein_id:AAM54167.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • locus:nhr-66 status:Partially_confirmed TR:Q8MXH0 protein_id:AAM54167.1 [wormpep115.fasta.reversed]
  • CE31062 WBGene00003656 locus:nhr-66 status:Confirmed UniProt:Q8MXH0_CAEEL protein_id:AAM54167.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE31062 WBGene00003656 locus:nhr-66 status:Confirmed UniProt:Q8MXH0_CAEEL protein_id:AAM54167.1| [wormORF-contam.fasta]
  • Nuclear hormone receptor family protein 66, isoform b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Nuclear Hormone Receptor family member (nhr-66) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE31062 WBGene00003656 locus:nhr-66 status:Confirmed UniProt:Q8MXH0 protein_id:AAM54167.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE31062 WBGene00003656 locus:nhr-66 status:Confirmed UniProt:Q8MXH0 protein_id:CCD63563.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • Isoform of H2KYJ8, Nuclear Hormone Receptor family OS=Caenorhabditis elegans GN=nhr-66 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 526 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVIRLLDFM TASTDVFAAM DMSQKQSSPP GIFKIAKNEP SSSSNSQPGT PAMGDRRAVP  60
   61 ACAICGTDST GIHFGVDACA ACSAFFRRTV VLNKDYSCNK GGKCTVVKDG SAGQKCRACR 120
  121 FRKCISSGMD KNSVQHRRDA IGKYSAGVKR ELSPDAEFEP SAKVSTVSEP STSSGPSGGF 180
  181 NQNVSSPAGI PRVPSTLRTT QASTCMNSAC GQKSVLHELI CRQNFLTEQR QLFYAGCLGD 240
  241 WFRKPSSIEN QTLSELTDFS SCMFHLWKIE PRLAADFMNR NRYLDPLPIV EKLKIYRNFV 300
  301 IMRQSVEEPY LTWRHGGLEK RWFVMPNNTY IDFNNIAKYF ENGALKDLKL DYETTTNLFL 360
  361 PSFTHAMDTI GEKMKKNNIT ETELTILLGL VLLDPGIYGI HESTRKFLKR IRDQLIHDVY 420
  421 MYYEDEMSHL YDPEIRMADI FMLVAAIKIH SIKTSENMHM LRVFDLIPAD ACFNQMLDVE 480
  481 SVNVSPDGQK DSEAEQGPSP VSVPEAARGS YQDDDMPPVL EKNCDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] PSI-BLAST 24.69897 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
    2 View Details [184..526] PSI-BLAST 39.09691 Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.15996699473685 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.46162010671465 bayes_pls_golite062009
  • protein binding
    		•  0.33427459029264 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.15459949087509 bayes_pls_golite062009
  • DNA binding
    		•  0.14395376162921 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle