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Protein Overview: ptp-1

General Information:
Name(s) found: ptp-1 / CE31450 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00004213 locus:ptp-1 Tyrosine-protein phosphatase 1 status:Partially_confirmed UniProt:P28191 protein_id:CAD44107.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 589 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEALink to PubMed article]
    cytoplasm [IEALink to PubMed article]
    extrinsic to membrane [IEALink to PubMed article]
    Biological Process: protein amino acid dephosphorylation [IEALink to PubMed article]
    dephosphorylation [IEALink to PubMed article]
    Molecular Function: protein binding [IEALink to PubMed article]
    protein tyrosine phosphatase activity [IEALink to PubMed article]
    phosphatase activity [IEALink to PubMed article]
    cytoskeletal protein binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRRRTARTS ESSAPSLRQQ RLSKEAIYYG TQESCDEKSW TPSMACTSTS PGIHASTASV  60
   61 RPVSSGSTPN GASRKSANSG YSGYGYATQT QQPTSTTNAS YSPYLNGTIS RSSGAAVAKA 120
  121 AARGLPPTNQ QAYNTSSPRN SVASYSSFAS AGIGGSPPRS KRSPQSNKSS SPVGEDQVVT 180
  181 IKMRPDRHGR FGFNVKGGAD QNYPVIVSRV APGSSADKCQ PRLNEGDQVL FIDGRDVSTM 240
  241 SHDHVVQFIR SARSGLNGGE LHLTIRPNVY RLGEEVDEPD STMVPEPARV ADSVPNSDKL 300
  301 SKSLQLLADS LNSGKVVDHF EMLYRKKPGM SMNICRLTAN LAKNRYRDVC PYDDTRVTLQ 360
  361 ASPSGDYINA NYVNMEIPSS GIVNRYIACQ GPLAHTSSDF WVMVWEQHCT TIVMLTTITE 420
  421 RGRVKCHQYW PRVFETQEYG RLMIKCIKDK QTTNCCYREF SIRDRNSSEE RRVTQMQYIA 480
  481 WPDHGVPDDP KHFIQFVDEV RKARQGSVDP IVVHCSAGIG RTGVLILMET AACLVESNEP 540
  541 VYPLDIVRTM RDQRAMLIQT PGQYTFVCES ILRAYHDGTI KPLAEYSKR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] MSA 7.173997 View MSA. No confident structure predictions are available.
    2 View Details [155..279] PSI-BLAST 11.154902 Solution structure of PDZ domain of Protein tyrosine phosphatase, non-receptor type 4
    3 View Details [280..589] PSI-BLAST 75.045757 No description for 2i75A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein binding
    		•  3.40921081688513 bayes_pls_golite062009
  • binding
    		•  3.2595117613307 bayes_pls_golite062009
  • phosphatase activity
    		•  2.36315753814254 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  2.3400854724675 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.31425709018481 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.0332243159956 bayes_pls_golite062009
  • kinase activity
    		•  1.60310055540266 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.42576125485675 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.37626136403014 bayes_pls_golite062009
  • transporter activity
    		•  1.18978519116375 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  1.10674192505247 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07211582292329 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.06018756723145 bayes_pls_golite062009
  • signal transducer activity
    		•  1.06018756723145 bayes_pls_golite062009
  • transferase activity
    		•  1.02891276124789 bayes_pls_golite062009
  • PDZ domain binding
    		•  0.87883331498113 bayes_pls_golite062009
  • receptor binding
    		•  0.867295068429704 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.755223974149211 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.740091060781601 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.64214865642772 bayes_pls_golite062009
  • peptidase activity
    		•  0.555029889463539 bayes_pls_golite062009
  • protein kinase binding
    		•  0.54934142458843 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.549085929250683 bayes_pls_golite062009
  • kinase binding
    		•  0.541050170070789 bayes_pls_golite062009
  • hydrolase activity
    		•  0.534910002338727 bayes_pls_golite062009
  • enzyme binding
    		•  0.46071739042312 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.403457741099606 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.281958912690177 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252733105474942 bayes_pls_golite062009
  • phosphatase binding
    		•  0.24515474358339 bayes_pls_golite062009
  • structural molecule activity
    		•  0.153277808949873 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0187659836234897 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle