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Protein Overview: lgc-33

General Information:
Name(s) found: lgc-33 / CE30056 [WormBase]
Description(s) found:
Found 15 descriptions.
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  • WBGene00021941 locus:lgc-33 status:Partially_confirmed UniProt:Q8WTK7 protein_id:AAK68534.3 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 444 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic membrane [IEALink to PubMed article]
    integral to membrane [IEALink to PubMed article]
    Biological Process: ion transport [IEALink to PubMed article]
    Molecular Function: extracellular ligand-gated ion channel activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVASKKIGMM AFTKLACLLL LFYQFSLVSS ISQNELNELS RKFKYYHSAV RPAAPDNFVS  60
   61 DRNGTFFNIP VEIHLLATRI VNRNLYLEVI IVMTWIDERL RLRELQDRFS MPSEYPPWHP 120
  121 SLVFAPPVTS KYTTLAPTSG TVNSYNTIKT TVECQTNAWK YPFESFTCTL SVGPEGDETL 180
  181 TVAQFHDLRS HTQKLLTNVF LGDYPTCSLE FIFKSEWPRA LLSSFLPSIL IVSSVFFAQW 240
  241 KRRKIQILVS LAAMLCSQRP YTSTTLMDLW LCANFIHSVF LVFVDLTLPA RRVRYTLMVH 300
  301 VDEEKKQANP VKIMTSGRFF GCSSASFEFI KKLSTNKLCT IKFHTISGNL HSVSLRLSSS 360
  361 HTIYLADTEH SGPLRYVNHV IDYLMKKEHK PRTTIVTACP GPTPIQRQIT TAMLGNRKRA 420
  421 ALFCIFLSYL TFLLIYAIIV IVID

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..308] PSI-BLAST 48.522879 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
    2 View Details [309..444] PSI-BLAST 21.39794 Acetylcholine receptor protein, beta chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transporter activity
    		•  0.8634160537398 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.85769987951557 bayes_pls_golite062009
  • channel activity
    		•  0.82494017759356 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.82494017759356 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.699135829541381 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.69403270260693 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.68865958955334 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.67623695447613 bayes_pls_golite062009
  • ion channel activity
    		•  0.675765443996379 bayes_pls_golite062009
  • gated channel activity
    		•  0.60374435462213 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.60262355448371 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.60262355448371 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.544647628998121 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.537135922480839 bayes_pls_golite062009
  • cation channel activity
    		•  0.53391585932077 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  0.463355765957441 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  0.463355765957441 bayes_pls_golite062009
  • nicotinic acetylcholine-activated cation-selective channel activity
    		•  0.26375810963714 bayes_pls_golite062009
  • binding
    		•  0.227765742225932 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle