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Protein Overview: div-1

General Information:
Name(s) found: div-1 / CE28840 [WormBase]
Description(s) found:
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  • WBGene00001002 locus:div-1 DNA polymerase alpha subunit B status:Partially_confirmed UniProt:Q21625 protein_id:CAA83467.2 [WormBase]
  • gi|21431778|sp|Q21625.3|DPOA2_CAEEL RecName: Full=DNA polymerase alpha subunit B; AltName: Full=Division delayed protein 1 [NCBI NR]
  • gi|18136205|emb|CAA83467.2| C. elegans protein R01H10.1, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17554432|ref|NP_499268.1| cell DIVision defective family member (div-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|15718355|emb|CAA21753.2| C. elegans protein R01H10.1, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • DNA polymerase alpha subunit B OS=Caenorhabditis elegans GN=div-1 PE=3 SV=3 [Swiss-Prot]
  • (Q21625) Probable DNA polymerase alpha subunit B [Swiss-Prot]
  • [wormpep67.fasta]
  • CE28840 WBGene00001002 locus:div-1 DNA polymerase alpha associated subunit status:Partially_confirmed SW:Q21625 protein_id:CAA21753.2 [wormpep150.fasta]
  • 28840 WBGene00001002 locus:div-1 DNA polymerase alpha associated subunit status:Partially_confirmed SW:Q21625 protein_id:CAA21753.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • polymerase alpha, cell DIVision defective DIV-1, Cell Cycle Delay CCD-1 (64.1 kD) (div-1) [Caenorhabditis elegans]gi|18136205|emb|CAA83467.2| Hypothetical protein R01H10.1 [Caenorhabditis elegans]gi|15718355|emb|CAA21753.2| Hypothetical protein R01H10.1 [nrdb_11152004_Chlamydomonas]
  • locus:div-1 DNA polymerase alpha associated subunit status:Partially_confirmed SW:Q21625 protein_id:CAA21753.2 [wormpep115.fasta.reversed]
  • CE28840 DNA polymerase alpha associated subunit status:Partially_confirmed SW:Q21625 protein_id:CAA83467.2 [wormpep80.hongbin]
  • CE28840 WBGene00001002 locus:div-1 DNA polymerase alpha associated subunit status:Partially_confirmed UniProt:Q21625 protein_id:CAA83467.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE28840 WBGene00001002 locus:div-1 DNA polymerase alpha associated subunit status:Partially_confirmed UniProt:Q21625 protein_id:CAA83467.2| [wormORF-contam.fasta]
  • cell DIVision defective family member (div-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • DNA polymerase subunit alpha B (Division delayed protein 1) [nr-271106-contam.fasta]
  • Hypothetical protein R01H10.1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE28840 WBGene00001002 locus:div-1 status:Partially_confirmed UniProt:Q21625 protein_id:CAA83467.2 DNA polymerase alpha subunit B [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 581 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: DNA replication [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    DNA-directed DNA polymerase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYEFDLEDF NDNLEPFGFN CPAKDHFIEK LEGLCKTFRK SGEDIVDDVV SVMSNLGQKS  60
   61 VDSGILAKLE ENLEAQAQKT VHTPRSVKKP ARGRVPLAEK SGFILSGDPD DIEKPSHHLT 120
  121 NSAIAKLEGH FLDFSPFPGS PANEKFLKRA DPSHVVTTIR GKKYQDKGLK GSTKSDDTIR 180
  181 IISKTPSTLY GGDKSSMVIE AKAQRMADIA HRIQKSFEEI VDWGNPSIPS VDVVYTYGQV 240
  241 IHDETKDNEK FGEHSVALMI NDEDGTMIRM DFSKMTEDIT LFPGQIIAVR GTNETGEELQ 300
  301 VDKIFQPAAL PVNPVETDTT KEIWFACGPY TATDNCGYEH LCELLDKVVA EKPDILMLAG 360
  361 PFVDKKNTFL NKPTFNITYD NLLEDLLLKV KETLVGTKTQ VIIQPNASRD LCVPPVFPSA 420
  421 PFQQNRKLDK IKKELIFVAD PCIFRISGVE VAMTSSEPIQ ALSNTEFHRS ANQENIDRVA 480
  481 RLSSHLLTQQ CMYPLEPTEV PASMGDLLDV CCIGSTPHIV FAPTKLAPSA KCVNGSVFIN 540
  541 SSTLAKGPTG NYAKMSINLN AGELMPGETV ADYAQIQILK I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] MSA 1.062985 View MSA. No confident structure predictions are available.
    2 View Details [145..253] deduced N/A No confident structure predictions are available.
    3 View Details [254..581] FFAS03 1.7 Structure of Vacuolar Protein Sorting 29 from Cryptosporidium Parvum

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • hydrolase activity
    		•  1.92175568522677 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.74029033853014 bayes_pls_golite062009
  • catalytic activity
    		•  1.30037658165549 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.17916462117542 bayes_pls_golite062009
  • binding
    		•  0.908738313033381 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  0.768201004870964 bayes_pls_golite062009
  • transporter activity
    		•  0.738056916803442 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.463083693607652 bayes_pls_golite062009
  • protein binding
    		•  0.32656262395659 bayes_pls_golite062009
  • phosphatase activity
    		•  0.325160962990544 bayes_pls_golite062009
  • structural molecule activity
    		•  0.211411396269789 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.179830790414814 bayes_pls_golite062009
  • protein transporter activity
    		•  0.0516488968911069 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle