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Protein Overview: daf-16

General Information:
Name(s) found: daf-16 / CE28772 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00000912 locus:daf-16 Forkhead box protein O status:Confirmed UniProt:O16850 protein_id:CCD71851.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 508 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article][IEALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: response to heat [IEPLink to PubMed article]
    dauer larval development [IGILink to PubMed article]
    insulin receptor signaling pathway [IDALink to PubMed article]
    determination of adult lifespan [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article][IEALink to PubMed article]
    protein binding [IPILink to PubMed article]
    sequence-specific DNA binding [IDALink to PubMed article][IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMEMLVDQGT DASSSASTST SSVSRFGADT FMNTPDDVMM NDDMEPIPRD RCNTWPMRRP  60
   61 QLEPPLNSSP IIHEQIPEED ADLYGSNEQC GQLGGASSNG STAMLHTPDG SNSHQTSFPS 120
  121 EMSESPDDTV SGKKTTTRRN AWGNMSYAEL ITTAIMASPE KRLTLAQVYE WMVQNVPYFR 180
  181 DKGDSNSSAG WKNSIRHNLS LHSRFMRIQN EGAGKSSWWV INPDAKPGRN PRRTRERSNT 240
  241 IETTTKAQLE KSRRGAKKRI KERALMGSLH STLNGNSIAG SIQTISHDLY DDDSMQGAFD 300
  301 NVPSSFRPRT QSNLSIPGSS SRVSPAIGSD IYDDLEFPSW VGESVPAIPS DIVDRTDQMR 360
  361 IDATTHIGGV QIKQESKPIK TEPIAPPPSY HELNSVRGSC AQNPLLRNPI VPSTNFKPMP 420
  421 LPGAYGNYQN GGITPINWLS TSNSSPLPGI QSCGIVAAQH TVASSSALPI DLENLTLPDQ 480
  481 PLMDTMDVDA LIRHELSQAG GQHIHFDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..102] MSA 2.316991 View MSA. No confident structure predictions are available.
    2 View Details [103..291] PSI-BLAST 24.522879 Afx (Foxo4)
    3 View Details [292..508] MSA 6.396996 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle