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Protein Overview: pde-4

General Information:
Name(s) found: pde-4 / CE28641 [WormBase]
Description(s) found:
Found 19 descriptions.
SHOW ALL
  • WBGene00020114 locus:pde-4 Probable 3',5'-cyclic phosphodiesterase pde-4 status:Partially_confirmed UniProt:Q22000 protein_id:CCD69647.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 626 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: signal transduction [IEALink to PubMed article]
    Molecular Function: catalytic activity [IEALink to PubMed article]
    3',5'-cyclic-nucleotide phosphodiesterase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCGSRRHLRR NEDGMNGVAR RKQFKLRPWQ STALPSRHDH YSCAGSATAA DGLGGAHLTP  60
   61 SLSSSVHARR ESFLYRASDD LREASSLRPV SRASSIASNE HGHGDDLIVT PFAQLLASLR 120
  121 NVRSNLISIT NIQNSDDSRH ANRSAKRPPL HNIELPDDVV HCAHDTLEEL DWCLDQLETI 180
  181 QTHRSVSEMA SSKFRKMLNK ELSHFAESSK SGTQVSKFLI TTYMDKEEDE PSIEIEVPTE 240
  241 VQGPSTSGPM TLSILKKAQT AAMNKISGVR KLRAPSHDGH VPEYGVNCAR EIAVHMQRLD 300
  301 DWGPDVFKID ELSKNHSLTV VTFSLLRQRN LFKTFEIHQS TLVTYLLNLE HHYRNNHYHN 360
  361 FIHAADVAQS MHVLLMSPVL TEVFTDLEVL AAIFAGAVHD VDHPGFTNQY LINSNNELAI 420
  421 MYNDESVLEQ HHLAVAFKLL QDSNCDFLAN LSRKQRLQFR KIVIDMVLAT DMSKHMSLLA 480
  481 DLKTMVEAKK VAGNNVIVLD KYNDKIQVLQ SMIHLADLSN PTKPIELYQQ WNQRIMEEYW 540
  541 RQGDKEKELG LEISPMCDRG NVTIEKSQVG FIDYIVHPLY ETWADLVYPD AQNILDQLEE 600
  601 NREWYQSRIP EEPDTARTVT EDDEHK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] MSA 5.061987 View MSA. No confident structure predictions are available.
    2 View Details [154..229] MSA 2.13499 View MSA. No confident structure predictions are available.
    3 View Details [230..626] PSI-BLAST 125.0 Catalytic domain of cyclic nucleotide phosphodiesterase pde4d

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  2.9145758096876 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  2.80645470666968 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  2.4031735631386 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  2.2478354053668 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.431522480252729 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.328473240612263 bayes_pls_golite062009
  • binding
    		•  0.0840884387362641 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle