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View Structure Prediction Details

Protein: pde-4
Organism: Caenorhabditis elegans
Length: 626 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pde-4.

Description E-value Query
Range
Subject
Range
gi|73956336 - gi|73956336|ref|XP_536678.2| PREDICTED: similar to phosphodiesterase 4B, cAMP-specific (phosphodiest...
674.0 [0..13] [623..44]

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Predicted Domain #1
Region A:
Residues: [1-153]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCGSRRHLRR NEDGMNGVAR RKQFKLRPWQ STALPSRHDH YSCAGSATAA DGLGGAHLTP  60
   61 SLSSSVHARR ESFLYRASDD LREASSLRPV SRASSIASNE HGHGDDLIVT PFAQLLASLR 120
  121 NVRSNLISIT NIQNSDDSRH ANRSAKRPPL HNI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [154-229]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELPDDVVHCA HDTLEELDWC LDQLETIQTH RSVSEMASSK FRKMLNKELS HFAESSKSGT  60
   61 QVSKFLITTY MDKEED

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [230-626]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EPSIEIEVPT EVQGPSTSGP MTLSILKKAQ TAAMNKISGV RKLRAPSHDG HVPEYGVNCA  60
   61 REIAVHMQRL DDWGPDVFKI DELSKNHSLT VVTFSLLRQR NLFKTFEIHQ STLVTYLLNL 120
  121 EHHYRNNHYH NFIHAADVAQ SMHVLLMSPV LTEVFTDLEV LAAIFAGAVH DVDHPGFTNQ 180
  181 YLINSNNELA IMYNDESVLE QHHLAVAFKL LQDSNCDFLA NLSRKQRLQF RKIVIDMVLA 240
  241 TDMSKHMSLL ADLKTMVEAK KVAGNNVIVL DKYNDKIQVL QSMIHLADLS NPTKPIELYQ 300
  301 QWNQRIMEEY WRQGDKEKEL GLEISPMCDR GNVTIEKSQV GFIDYIVHPL YETWADLVYP 360
  361 DAQNILDQLE ENREWYQSRI PEEPDTARTV TEDDEHK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 125.0
Match: 1oynA
Description: Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclic-nucleotide phosphodiesterase activity 2.9145758096876 bayes_pls_golite062009
3',5'-cyclic-nucleotide phosphodiesterase activity 2.80645470666968 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 2.4031735631386 bayes_pls_golite062009
phosphoric diester hydrolase activity 2.2478354053668 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.431522480252729 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.328473240612263 bayes_pls_golite062009
binding 0.0840884387362641 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle