Protein Overview: unc-70

General Information:
Name(s) found:	unc-70 / CE28604 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00006803 locus:unc-70 status:Confirmed UniProt:G5EG85 protein_id:CCD72900.1 [WormBase] gi\|8118453\|gb\|AAF72996.1\|AF261891_1 beta-spectrin [Caenorhabditis elegans] [NCBI NR] gi\|71999955\|ref\|NP_001024052.1\| UNCoordinated family member (unc-70) [Caenorhabditis elegans] [NCBI NR] gi\|5734148\|gb\|AAD49859.1\|AF166170_1 beta-G spectrin [Caenorhabditis elegans] [NCBI NR] ref\|NP_504748.1\| beta-G spectrin, UNCoordinated locomotion UNC-70 (262.2 kD) (unc-70) [Caenorhabditis elegans] [NCBI NR] gi\|15011760\|gb\|AAK77611.1\|U64854_3 Hypothetical protein K11C4.3a [Caenorhabditis elegans] [NCBI NR] [wormpep67.fasta] CE28604 WBGene00006803 locus:unc-70 spectrin beta chain status:Confirmed TR:Q9U9J7 protein_id:AAK77611.1 [wormpep150.fasta] 28604 WBGene00006803 locus:unc-70 spectrin beta chain status:Confirmed TR:Q9U9J7 protein_id:AAK77611.1 [wormpep130-phg-ecoli-orf-rand.fasta] beta-G spectrin, UNCoordinated locomotion UNC-70 (262.2 kD) (unc-70) [Caenorhabditis elegans]gi\|15011760\|gb\|AAK77611.1\| Uncoordinated protein 70, isoform a [Caenorhabditis elegans]gi\|5734148\|gb\|AAD49859.1\| beta-G spectrin [Caenorhabditis elegans]gi\|811 [nrdb_11152004_Chlamydomonas] locus:unc-70 spectrin beta chain status:Confirmed TR:Q9U9J7 protein_id:AAK77611.1 [wormpep115.fasta.reversed] CE28604 locus:unc-70 spectrin beta chain status:Confirmed [wormpep80.hongbin] CE28604 WBGene00006803 locus:unc-70 spectrin beta chain status:Confirmed UniProt:Q9U9J7_CAEEL protein_id:AAK77611.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE28604 WBGene00006803 locus:unc-70 spectrin beta chain status:Confirmed UniProt:Q9U9J7_CAEEL protein_id:AAK77611.1\| [wormORF-contam.fasta] beta-spectrin [Caenorhabditis elegans] [nr-271106-contam.fasta] beta-G spectrin [Caenorhabditis elegans] [nr-271106-contam.fasta] Uncoordinated protein 70, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta] UNCoordinated family member (unc-70) [Caenorhabditis elegans] [nr-271106-contam.fasta] CE28604 WBGene00006803 locus:unc-70 spectrin beta chain status:Confirmed UniProt:Q9U9J7 protein_id:AAK77611.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE28604 WBGene00006803 locus:unc-70 spectrin beta chain status:Confirmed UniProt:G5EG85 protein_id:CCD72900.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE28604 WBGene00006803 locus:unc-70 status:Confirmed UniProt:G5EG85 protein_id:CCD72900.1 [wormpep246-ecoli-contam.fasta] Isoform of E0AHA7, Beta-G spectrin OS=Caenorhabditis elegans GN=unc-70 PE=1 SV=1 [CAEEL.fasta.20160308]
Organism:	Caenorhabditis elegans
Length:	2257 amino acids
Gene Ontology:
Cellular Component:	lateral plasma membrane [IDA] cytoplasm [IDA] cell junction [IDA] I band [IDA] smooth muscle dense body [IDA] M band [IDA] integrin complex [IDA] proteinaceous extracellular matrix [IEA]
Biological Process:	DNA repair [IEA] muscle cell homeostasis [IMP] locomotory behavior [IMP ] regulation of locomotion [IMP] nematode larval development [IMP] embryonic body morphogenesis [IGI] positive regulation of growth rate [IMP] cell adhesion [IEA] neuron development [IMP] blood coagulation [IEA] dendrite development [IMP] positive regulation of locomotion [IMP]
Molecular Function:	actin binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATVDGNSGA YTQDEDYDDN SSARLFERSR IKALADEREL VQKKTFTKWV NSHLVRVSCK  60
   61 VQDLYMDMRD GKMLLRLLAV LSGERLPKPT PGKMRIHCLE NVEKGLQFLR NQHVHLENLG 120
  121 SHDIVDGNSR LTLGLIWTII LRFQIQDITF EDADNHETRS AKEALLLWCQ MKTAGYPNVN 180
  181 VKNFSTSWRD GLAFNALIHK HRPDLVDYDN LQKSNALYNL QSAFDTAENQ LGLAKFLDAE 240
  241 DVNVDQPDEK SIITYVVTYY HYFNKLKQDN IQGKRIGKVI NELMENDKMI NRYETLSSDL 300
  301 LEWINAKIQL LNERHFENNL EGVQRQLTEF NDYRTQEKPP KFDEKGELEV LLFTLQSAMR 360
  361 ANNQRPFVPR EGKLIADINR AWQSLEKAEH ERELVLKEEL IRQEKLEQLA ARFNRKAEMR 420
  421 ETWLTENQRL VSQDNFGNDL SSVEAATKKH EAIETDIFAY EERVQAVVAV AGELEAENYH 480
  481 DQAKINERKE NVLQLWNYLF QLLLARRVRL ELSMAIQKIF HDMLLTLDLM DDIKSRLLSE 540
  541 DLGAHLMDVE DLLQKHALLE SDINIIGERV NNSIAQAQRF RNPDGPDGSG YKPVEPGTID 600
  601 ERSDVLQKRY KELLDLAAER KRRLEDNKRL CQFWWDVAEL EHGIKEQEQV LSSTDTGRDI 660
  661 VTVSHLLAKH KNAENNLRDL EKYLDRLDVS GKELQDESIP GSDNIPPRLA EIRDYINKLK 720
  721 ELSASRKERL AGGVEYYQFF TDADDVDRYL YDTLRVMSSE DVGKDEGTVQ LLLKKHDDVH 780
  781 DELQNFDQHI KVLHAKAESL PQEAREHPDI RQRLDTTLKQ KAELENLSQL RKQRLIDALS 840
  841 LYKLYSDADS VESWIDEKGK LLATLVPGRD IEEVEIMKHR FDTLEQDMKN QEAKVTNVND 900
  901 LARQLLNVEH PNSDDILHRQ NKLNARWAQL RDMVDQKRNE LERAHRLETF RIDCQETVTW 960
  961 IEDKTRVLED SDALTNDLSG VMKLQRRLSM MERDLGAIQA KLDSLHKEAD DIERERPQEA1020
 1021 QAIREDIKRI HQVWDILNKK VREHEAKLDE AGDLQRFLRD LDHFQAWLTA TQRQVASEEE1080
 1081 PQSLAEAEQL LNQHAAIREE IDGYAEDYKK MRAMGDRVTQ DQTDPQYMFL RQRLAGLQEG1140
 1141 WEELQRMWDN RQHLLSQGLN LQMFLRDAKQ AEVMLSQQEN YLAKDDIPQS LEQAENQLKR1200
 1201 HQDFITTMDA NDEKIRAVGM FGDQLCQDGH YAADKIHKKA RNIDERRGAN REKAQEVLKK1260
 1261 LKDALSLQQF LSDCDELREW IEEKMIRAQD ETYRDAKTIT SKFVRHQAFQ SELAANKERL1320
 1321 DQLKHAAINL GDDKPEYHGT IDPQIEELAT QWDELEKTTE EKGQKLFDAN RQQLYVQSIA1380
 1381 DMKEWATQLE NEMTREDQPG DLTTVNVAMQ KQHLIETEMI KKAQHIDQLM EMEPQLEELH1440
 1441 PDELENIKAH RLAVQEQLQR LQAPLDDRRK ALERKKAAFQ FGRDVDDEKL WISERLVLAK1500
 1501 AQNLGESLPD CHRLQKNLQL LSNEIDNHEP WINQICNNGQ ELIDEGHANG PAFEKKIQEL1560
 1561 RSAWQELKEA VKDRKGDLGE SEKAHQFLYD CGEAEAWMSE QELYMMQDER GKDEFSTKNQ1620
 1621 IKKHERLQSD IDKFADTIRA LATKAHKFVE EKSPLTEQIQ VRQAQIEKLY AGLQDLSKER1680
 1681 RKRLEETLEL YALHREIDDL LQWIADKEVV AGSQENGQDY EHVQMLQERF QQFARDTENI1740
 1741 GSERVANAND GCDTLIGHGH TDAPTIALWK DSLNEAWENL LELMDTRAQI LEASRLLHKF1800
 1801 YHDCRDCLSR IMEKTHAMPD DLGRDSSSVG ALSRKHQNYL KDIAAIGEQV AQIERDAAEL1860
 1861 RDGYAGDKAL DIGSRESEVV KAWRHLRGLC DARTSRLMDT SDLFKFMNMV RDLLLWMDEV1920
 1921 KREMNSQERP KDVSGVELLM NNHQSLKAEI DAREENFNAC ISLGRDLLNR KHYASSEIEK1980
 1981 KLIKLTTERA EMMRRWEDRW EYLQLILEVY QFARDAAVAE SWLFAQEPYL ISKEYGRNLE2040
 2041 ETIKLIKKHE AFEKSAFAQE ERFLALEKLT TFELKETQHR EEETAKRRGP AHIGSPSRST2100
 2101 PAAETSFGAQ DDGAKQGEAF EGTLIRKHTY ESLDRKAANR SWEKLYAVLR QNELSFYKDP2160
 2161 KHRDESVHGE PPMALPGCSV NVASDYQKKK NVLSLRLPIG AEYLFQCGSE EDMQRWLTEL2220
 2221 QVATGQAQLE EASRSQTLPA EGSATKKKGG FFSRGKK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	hcp-1	hcp1 IP from december2004	Cheeseman, I.M., et al. (2005)
View Run	hcp-2	hcp2 ip from december	Cheeseman, I.M., et al. (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: unc-70

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: