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Protein Overview: zyg-12

General Information:
Name(s) found: zyg-12 / CE28524 [WormBase]
Description(s) found:
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  • WBGene00006997 locus:zyg-12 Zygote defective protein 12 status:Confirmed UniProt:Q23529 protein_id:CCD73212.1 [WormBase]
  • gi|71998870|ref|NP_001022522.1| ZYGote defective: embryonic lethal family member (zyg-12) [Caenorhabditis elegans] [NCBI NR]
  • gi|45430244|gb|AAS60253.1| Zygote defective: embryonic lethal protein 12, isoform b [Caenorhabditis elegans] [NCBI NR]
  • gi|116242867|sp|Q23529.5|ZYG12_CAEEL RecName: Full=Zygote defective protein 12 [NCBI NR]
  • Zygote defective protein 12 OS=Caenorhabditis elegans GN=zyg-12 PE=1 SV=5 [Swiss-Prot]
  • [wormpep67.fasta]
  • Zygote defective: embryonic lethal protein 12, isoform b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE28524 WBGene00006997 locus:zyg-12 cytoskeletal linker protein status:Confirmed SW:Q23529 protein_id:AAS60253.1 [wormpep150.fasta]
  • 28524 WBGene00006997 locus:zyg-12 cytoskeletal linker protein status:Partially_confirmed protein_id:AAS60253.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE28524 WBGene00006997 locus:zyg-12 cytoskeletal linker protein status:Partially_confirmed protein_id:AAS60253.1 [wormpep132.fasta]
  • 28524 WBGene00006997 locus:zyg-12 cytoskeletal linker protein status:Confirmed SW:Q23529 protein_id:AAS60253.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE28524 WBGene00006997 locus:zyg-12 cytoskeletal linker protein status:Confirmed protein_id:AAS60253.1 [WormBase_C-elegans_na_01-20-2005_combined_reversed.fasta]
  • CE28524 status:Partially_confirmed TR:Q23529 protein_id:AAA68733.2 [wormpep80.hongbin]
  • CE28524 WBGene00006997 locus:zyg-12 cytoskeletal linker protein status:Confirmed UniProt:ZYG12_CAEEL protein_id:AAS60253.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE28524 WBGene00006997 locus:zyg-12 cytoskeletal linker protein status:Confirmed UniProt:ZYG12_CAEEL protein_id:AAS60253.1| [wormORF-contam.fasta]
  • Zygote defective protein 12 [nr-271106-contam.fasta]
  • ZYGote defective: embryonic lethal family member (zyg-12) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE28524 WBGene00006997 locus:zyg-12 cytoskeletal linker protein status:Confirmed UniProt:Q23529 protein_id:AAS60253.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • CE28524 WBGene00006997 locus:zyg-12 cytoskeletal linker protein status:Confirmed UniProt:Q23529 protein_id:CCD73212.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE28524 WBGene00006997 locus:zyg-12 status:Confirmed UniProt:Q23529 protein_id:CCD73212.1 Zygote defective protein 12 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 777 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    centrosome [IDALink to PubMed article]
    Biological Process: centrosome localization [IMPLink to PubMed article]
    pronuclear migration [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    oviposition [IMPLink to PubMed article]
    nucleus localization [IMPLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    Molecular Function: dynein light intermediate chain binding [IPILink to PubMed article]
    protein self-association [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDLTNKESE SSDNGNSKYE DSIDGREVGT SKPFKEERSL EDLQADLADM AVWMEGLDAT  60
   61 KLPLNDPQLL CNGRAFSEVL HNVDKNFFTD GWLETMPENR TTNIMVFRSC TRKLWRKMFD 120
  121 YVNHINRTVV SSRWTDIHER IDGIYESDLP AMVNLGMAVV TLAHIGKNAK RFVDYSKALT 180
  181 STHKSMMSNV AKMVTTVIDE MPENPCFHEI SELHGSQSEL NSLSESSGKL NGNGSSERRS 240
  241 NADQILVDAE LEIERLRTET ENQRKEIERL TKSFETAQHD MSSNSESGDI SILEKQNEEL 300
  301 RQKRRELEEK NLELDAAVDQ FKGIVFELTN ENDVLRRSDK ERQRLQTVLD AAQSDLDEWK 360
  361 TVANQYQKEA ELSKQQDKEI KELLSQNKAL KSRLDHHVKS ATLEDANKNG IAQLRTQVGG 420
  421 LTALNTELKA SLDSKKRCVE QLEIQLIQHK EKVKELEDRK DELIEERNRL ENQLIFKEAV 480
  481 TPRSLHESMF EAGNLSFEPF SEKNTLPLEI ENKRLTERIQ ELESLEPLKG ELITLKSKNG 540
  541 VLEEEKLFAT KQIEELQQQI EDLQENLLKN QEHASGDVVG LKIQLEKAEV EAQQMREAKM 600
  601 RAETNQAQVD EILKKRTAEL EVNATALQKA KAVIDELEYN SRPVSEDSMT SVQAFKEMKE 660
  661 ENEKLRQKVE KLEIELNTVT QGFEQENRLL TSASHQQVLN RSIDEVMSMR AHAGSEEPQT 720
  721 LLDTQKMSGA LPWRSLASET RRELPTAMAS ILVLGFLVFI AWMFININSA LNAPPNA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..206] PSI-BLAST 11.0 The solution structure of RSGI RUH-026, conserved domain of HOOK1 protein from mouse
    2 View Details [207..358] FFAS03 1.91 Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
    3 View Details [359..777] PSI-BLAST 17.0 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.77302826695282 bayes_pls_golite062009
  • protein binding
    		•  1.34258839710246 bayes_pls_golite062009
  • microtubule binding
    		•  0.26034159312323 bayes_pls_golite062009
  • tubulin binding
    		•  0.11464228697646 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle