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Protein Overview: ace-2

General Information:
Name(s) found: ace-2 / CE28363 [WormBase]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • WBGene00000036 locus:ace-2 status:Confirmed UniProt:G5EDV9 protein_id:CCD73443.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 629 amino acids

    Gene Ontology:
    Cellular Component: cell [IDALink to PubMed article]
    Biological Process: synaptic transmission, cholinergic [IMPLink to PubMed article]
    regulation of locomotion [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    acetylcholine catabolic process [IDALink to PubMed article][IMPLink to PubMed article]
    acetylcholine catabolic process in synaptic cleft [ICLink to PubMed article]
    Molecular Function: protein homodimerization activity [IPILink to PubMed articleLink to PubMed article]
    acetylcholinesterase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRAPVIGRHL TYHVFCQFAL VTLFIVRRIE PRSIVRGDHV VHTPLGTIRG VGQTFDGAKV  60
   61 SAFLGVPYAK PPIGSRRFKM AEMIDRWSGE LEARTLAKTC YLTIDSAFPQ FPGAEMWNPP 120
  121 GAISEDCLNM NIWVPEDHDG SVMVWIYGGG FFSGTPSLDL YSGSVFAAKE HTIVVNVNYR 180
  181 LGPFGFLYFG DDSPIQGNMG LMDQQLALRW VHENIGAFGG DRSRVTLFGE SAGSASTTAH 240
  241 LFAPNSHKYF RNIIAKSGSI INSWASATPP TMLDLSFRLA KKVNCSSPDM NAIVKCLRSV 300
  301 PAHLVQAEAD NISGDIGPPM TFAYVPVSSD ANFFQGDVFQ KLANKQFKKD VNIIFGSVKD 360
  361 EGTYWLPYYM SLPKYGFAFN HTISAEDPHN RALITRDHYE ESMRAFMPYF AGSKLVLNAF 420
  421 MNSYEHVSTS NVPEERYRDG VARFLGDLFF TCSLIDFADL ISDNIFGNVY MYYFTYRSSA 480
  481 NPWPKWMGVM HGYEIEYAFG QPYWRPHLYD QTHLEDEKRL SSIIMQIWAN FANTGRTDSF 540
  541 WPQYNKIERK AIELGETTLQ GKHRIISDVH GGFCRMIDEA KAFVKQKNAN DCRTTRKSAS 600
  601 TEDLTSSSST TYLFSIIVYL SILISYISL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..629] PSI-BLAST 121.0 No description for 2pm8A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetylcholinesterase activity
    		•  6.01557374116734 bayes_pls_golite062009
  • cholinesterase activity
    		•  3.53190978140684 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.19190626066707 bayes_pls_golite062009
  • juvenile hormone epoxide hydrolase activity
    		•  2.90543792269229 bayes_pls_golite062009
  • laminin-1 binding
    		•  2.61620056180634 bayes_pls_golite062009
  • choline binding
    		•  2.44944581139315 bayes_pls_golite062009
  • acetylcholine binding
    		•  2.15366394064412 bayes_pls_golite062009
  • carboxylesterase activity
    		•  2.10340684157921 bayes_pls_golite062009
  • lipase activity
    		•  1.95656432876646 bayes_pls_golite062009
  • hydrolase activity
    		•  1.89798820741335 bayes_pls_golite062009
  • palmitoyl-(protein) hydrolase activity
    		•  1.63586830236611 bayes_pls_golite062009
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • sterol esterase activity
    		•  1.21262745914703 bayes_pls_golite062009
  • binding
    		•  0.978846093152455 bayes_pls_golite062009
  • peptidase activity
    		•  0.946698616106528 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  0.92549140936125 bayes_pls_golite062009
  • protein binding
    		•  0.890384359682543 bayes_pls_golite062009
  • receptor binding
    		•  0.845720597560984 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.786172015267385 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.715547007602635 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.527527404338 bayes_pls_golite062009
  • acylglycerol lipase activity
    		•  0.345658974420231 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.33062249657108 bayes_pls_golite062009
  • heparin binding
    		•  0.219437684278316 bayes_pls_golite062009
  • phospholipase activity
    		•  0.1336535306364 bayes_pls_golite062009
  • triglyceride lipase activity
    		•  0.05324087110088 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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