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Protein Overview: ars-1

General Information:
Name(s) found: ars-1 / CE28096 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00000196 locus:aars-1 Alanine--tRNA ligase, mitochondrial status:Confirmed UniProt:Q23122 protein_id:CAA91396.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 793 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: alanyl-tRNA aminoacylation [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    translation [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    alanine-tRNA ligase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIGSKILEN NIQKSISLGF YHSHSELRKS FYEFFKSKNH EILRSSSVIP DENDGTLLFT  60
   61 NAGMNQFKPL ILSSTESRRV ANIQKCIRAG GKHNDLDDVG KDLHHQTFFE MMGNWSFNDA 120
  121 FSKEEACRYA WEYLVEILGI NADRLYVSYF GGIEKLGLPE DRECREIWKR IGVSSNRILP 180
  181 FVAENFWEMG AAGPCGPCTE IHYDRIGGRD ASRLVNIDDS VVEIWNIVFM SSVRDSCGQI 240
  241 RHLGKNHIDT GMGFERLLSV VQNKTSNFDT DVFTPILEKT SELAKKQYTG SLDSRQDATF 300
  301 RLVADHIRAA TVAISDGAVP DGTGCGFIVR KMMRRAFLQG ISKLGIERYA MSELVPVVAS 360
  361 TMKEVYPEIH DTSTHIRKIF NDEEAQFWKT VDKAKKMFDS VAAESKSPII SGRKAFNLFE 420
  421 THGLPLAVTV ELARNIGREV DETEFERCRL EAQKVSQKAS QFKLPISADD FPSHSDKEKY 480
  481 SYVFRNGKYE FPQVKTRILQ VYKDQQKAES LEANDRGFLV LEECQFYGEQ GGQTSDTGHL 540
  541 LIDGREVFEV ENAKKIAGGA VTVLFGRALL PIRRDLRVEQ KLDETRREGV MRAHSATHLL 600
  601 NWALQKLGVG SGQKGSSVDC DRFRFDYSTG DEDLSKEQRT ELLIKCEMKM REFIQNGGFT 660
  661 EIIETSLEEA KKIENLQSDV KEDRIGGASV RVVALGSGAD VPVECCSGTH IHDVRVIDDV 720
  721 AIMSDKSMGQ RLRRIIVLTG KEAAACRNYT KSIYEDLRST DPKERSKTGK NIDWKRVPIA 780
  781 DQARISILLK QKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..492] PSI-BLAST 178.0 The crystal structure of the catalytic fragment of the alanyl-tRNA synthetase
    2 View Details [493..793] PSI-BLAST 65.39794 Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  6.00693881794242 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  2.76416144738864 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.17047432052132 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.07594942154162 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • binding
    		•  0.705666054154871 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle