Protein Overview: par-1

General Information:
Name(s) found:	par-1 / CE27768 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00003916 locus:par-1 Serine\/threonine-protein kinase par-1 status:Partially_confirmed UniProt:Q9TW45 protein_id:CAB54262.2 [WormBase] gi\|71997537\|ref\|NP_001024019.1\| abnormal embryonic PARtitioning of cytoplasm family member (par-1) [Caenorhabditis elegans] [NCBI NR] ref\|NP_741639.1\| serine/threonine kinase, establishes embryonic polarity; asymmetrically distributed., abnormal embryonic PARtitioning of cytoplasm PAR-1, ZYGote defective : embryonic lethal ZYG-14 (116.6 kD) (par-1) [Caenorhabditis elegans] [NCBI NR] gi\|14530522\|emb\|CAB54262.2\| C. elegans protein H39E23.1b, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|14530316\|emb\|CAB54178.2\| C. elegans protein H39E23.1b, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|1118007\|gb\|AAA83272.1\| serine/threonine kinase [NCBI NR] [wormpep67.fasta] CE27768 WBGene00003916 locus:par-1 status:Partially_confirmed TR:Q17368 protein_id:CAB54262.2 [wormpep150.fasta] 27768 WBGene00003916 locus:par-1 status:Confirmed TR:Q17368 protein_id:CAB54262.2 [wormpep130-phg-ecoli-orf-rand.fasta] serine/threonine kinase, establishes embryonic polarity; asymmetrically distributed., abnormal embryonic PARtitioning of cytoplasm PAR-1, ZYGote defective : embryonic lethal ZYG-14 (116.6 kD) (par-1) [Caenorhabditis elegans]gi\|14530522\|emb\|CAB54262.2\| Hy [nrdb_11152004_Chlamydomonas] CE27768 WBGene00003916 locus:par-1 status:Confirmed TR:Q17368 protein_id:CAB54262.2 [wormpep132.fasta] 27768 WBGene00003916 locus:par-1 status:Partially_confirmed TR:Q17368 protein_id:CAB54262.2 [wormpep150-phg-orf-ecoli-rand.fasta] status:Confirmed TR:Q17368 protein_id:CAB54262.2 [wormpep115.fasta.reversed] CE27768 status:Confirmed TR:Q17368 protein_id:CAB54262.2 [wormpep80.hongbin] CE27768 WBGene00003916 locus:par-1 status:Partially_confirmed UniProt:Q17368_CAEEL protein_id:CAB54262.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE27768 WBGene00003916 locus:par-1 status:Partially_confirmed UniProt:Q17368_CAEEL protein_id:CAB54262.2\| [wormORF-contam.fasta] serine/threonine kinase [nr-271106-contam.fasta] Hypothetical protein H39E23.1b [Caenorhabditis elegans] [nr-271106-contam.fasta] abnormal embryonic PARtitioning of cytoplasm family member (par-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] CE27768 WBGene00003916 locus:par-1 status:Partially_confirmed UniProt:Q9TW45 protein_id:CAB54262.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE27768 WBGene00003916 locus:par-1 status:Partially_confirmed UniProt:Q9TW45 protein_id:CAB54262.2 Serine\/threonine-protein kinase par-1 [wormpep246-ecoli-contam.fasta] Isoform of Q9TW45, Isoform b of Serine/threonine-protein kinase par-1 OS=Caenorhabditis elegans GN=par-1 [CAEEL.fasta.20160308]
Organism:	Caenorhabditis elegans
Length:	1096 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA] membrane [IDA]
Biological Process:	polarity specification of anterior/posterior axis [TAS] embryonic cleavage [IMP] vulval development [IMP] hermaphrodite genitalia development [IMP] establishment of mitotic spindle localization [IMP] asymmetric protein localization involved in cell fate determination [IMP] signal transduction [IEA] embryonic pattern specification [IGI][IMP] embryonic development ending in birth or egg hatching [IMP ] establishment of cell polarity [IMP] gamete generation [IMP] protein amino acid phosphorylation [IEA]
Molecular Function:	magnesium ion binding [IEA] ATP binding [IEA] protein tyrosine kinase activity [IEA] zinc ion binding [IEA] non-membrane spanning protein tyrosine kinase activity [IEA] protein kinase activity [IEA] protein serine/threonine kinase activity [IEA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRVSGYFMG ISKKNGQKKH PARPSTESST SSSHHRRPAQ EMNGTSTATA TGGGGTSGAT  60
   61 TTASSGAPAA SSGGSSARYS SSGRSHPTSG SSSSHARSTG QSGMSSRSAA RRNDQDVHVG 120
  121 KYKLLKTIGK GNFAKVKLAK HVITGHEVAI KIIDKTALNP SSLQKLFREV KIMKQLDHPN 180
  181 IVKLYQVMET EQTLYLVLEY ASGGEVFDYL VAHGRMKEKE ARAKFRQIVS AVQYLHSKNI 240
  241 IHRDLKAENL LLDQDMNIKI ADFGFSNTFS LGNKLDTFCG SPPYAAPELF SGKKYDGPEV 300
  301 DVWSLGVILY TLVSGSLPFD GQNLKELRER VLRGKYRIPF YMSTDCENLL KKFLVINPQR 360
  361 RSSLDNIMKD RWMNVGYEDD ELKPFIEPPK DQIDEQRIEK LIQIFQLGFN KAAILESVEK 420
  421 EKFEDIHATY LLLGERKSDP SRYSRSSATA TGASITAGSA LASAANAQKH QQSSAAPSSG 480
  481 SSSSRRSSQN DAAATAAGGT VVMSGTRHGG VQMRAQPTSR QATISLLQPP SYKPSSNTTQ 540
  541 IAQIPPLFNR NSTATSSAAQ PSTGITGTRK IADPKGRIPL NSTAVQGHRT ATGAVAANNG 600
  601 GIPSHRDHAQ QQQYMNQLTS STMMSKLINK TPAAGGTAAT SSSSSSSATS TAPLQKSGSQ 660
  661 ISHAPTEPVI REDDDENNSE NQNGNVPLIG GVGPQTSPAV QVPTEDATSS SDKEQQQQKA 720
  721 SSETPKESKP SMIHQSPSMP PSQMMTAMES LKLSESGQTG GPTVATGGPP QRATSQQMSR 780
  781 SATTNSANMG ASSGGAAAAA SATNQLSGAP SSTGASSQQY HPKAPSSSSS SSTNPPHQHQ 840
  841 LTHNASFSVT PSSYQIPTST AVNVTSTGMP TSSSSSAFPR NTRNRQTFHG KTEKDKGGDD 900
  901 SSDEIGETPG NVSIGATGPS ANNAEATIWS KLSKLTRRDH NRESMTQPVS GRAGTIGASQ 960
  961 GQQTAAALAA IREQSGPIAP GAGQVAPSLP IHEGDVKPRS LRFTWSMKTT SSLAPDDMMR1020
 1021 EIRKVLDANG CDYEQRERYM ILCVHGDPNT DSLVQWEMEV CKLPRLSLNG VRFKRISGTS1080
 1081 IGFKNIASKI AQELNL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	None Entered	No Comments	Cheeseman, I.M., et al. (2004)
View Run	gi\|7499968	No Comments	Cheeseman, I.M., et al. (2004)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.89

Protein Overview: par-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: