Protein Overview: CE27708

General Information:
Name(s) found:	CE27708 [WormBase]
Description(s) found: Found 18 descriptions. SHOW ALL	WBGene00015943 locus:tiar-1 status:Confirmed UniProt:Q95QV8 protein_id:CCD65015.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	408 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA]
Biological Process:	morphogenesis of an epithelium [IMP] nematode larval development [IMP] embryonic development ending in birth or egg hatching [IMP] mRNA processing [IEA] growth [IMP]
Molecular Function:	nucleic acid binding [IEA] RNA binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFNPPANS NHGYNDDVNT GYNARMHSKL AEREGFHLGN GSDEPRTLYV GNLDSTVTED  60
   61 FIATLFNQIG SVTKTKVIFD GSNDPYAFVE FSDHGQASQA LQTMNKRLLL DREMKVNWAV 120
  121 EPGQQQSKID TTRHFHVFVG DLSSEVDNQK LREAFQPFGD VSDAKVIRDT NTTKSKGYGF 180
  181 VSYPKREEAE RAIEQMNGQW LGRRTIRTNW ATRKPGDQEK PSHYNEKSYD EIYNQTSGDN 240
  241 TSVYVGNIAS LTEDEIRQGF ASFGRITEVR IFKMQGYAFV KFDNKDAAAK AIVQMNNQDV 300
  301 GGQLVRCSWG KTGDTGKTPG GSYGYGYGNS SSGGNSQPYS GYGGGGAYGG GQGGGGHGGP 360
  361 GQQQSNANSQ YWQYYAQYYN NPQLMQQWSN YWQQQGGAPQ QQNSGGHQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	None Entered	No Comments	Cheeseman, I.M., et al. (2004)
View Run	hcp-1	hcp1 IP from december2004	Cheeseman, I.M., et al. (2005)
View Run	hcp-2	hcp2 ip from december	Cheeseman, I.M., et al. (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..214]	PSI-BLAST	46.154902	HNRNP A1 (RBD1,2) FROM HOMO SAPIENS
2	View Details	[215..311]	FFAS03	3.88	Solution structure of RRM domain in Nucleolysin TIAR
3	View Details	[312..408]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
RNA binding	6.73097473547076	bayes_pls_golite062009
	6.62953239642182	bayes_pls_golite062009
mRNA binding	5.29759606920196	bayes_pls_golite062009
nucleic acid binding	4.92126426323641	bayes_pls_golite062009
snRNA binding	4.06596327298973	bayes_pls_golite062009
binding	3.64400841800969	bayes_pls_golite062009
poly-pyrimidine tract binding	3.11990160533699	bayes_pls_golite062009
U1 snRNA binding	3.02511982045347	bayes_pls_golite062009
single-stranded RNA binding	2.93798024346416	bayes_pls_golite062009
transcription regulator activity	2.18211199677674	bayes_pls_golite062009
DNA binding	1.98418556946403	bayes_pls_golite062009
structural molecule activity	1.56454315220334	bayes_pls_golite062009
U2 snRNA binding	1.34078165372485	bayes_pls_golite062009
protein binding	1.12215421354121	bayes_pls_golite062009
transcription factor activity	1.07843408116687	bayes_pls_golite062009
mRNA 3'-UTR binding	0.824614388276642	bayes_pls_golite062009
sequence-specific DNA binding	0.383589644462932	bayes_pls_golite062009

2

Term	Confidence	Notes
	6.40066880991253	bayes_pls_golite062009
RNA binding	6.32219487559982	bayes_pls_golite062009
mRNA binding	4.87640532914983	bayes_pls_golite062009
nucleic acid binding	4.65259034341669	bayes_pls_golite062009
snRNA binding	3.77997752511163	bayes_pls_golite062009
binding	3.48033873254013	bayes_pls_golite062009
U1 snRNA binding	2.73908382552928	bayes_pls_golite062009
poly-pyrimidine tract binding	2.7133834347239	bayes_pls_golite062009
single-stranded RNA binding	2.55628738360472	bayes_pls_golite062009
transcription regulator activity	2.2045206027152	bayes_pls_golite062009
DNA binding	1.99030664201171	bayes_pls_golite062009
structural molecule activity	1.57342338925793	bayes_pls_golite062009
transcription factor activity	1.09958329302628	bayes_pls_golite062009
U2 snRNA binding	1.09350203162237	bayes_pls_golite062009
protein binding	1.05805521997665	bayes_pls_golite062009
mRNA 3'-UTR binding	0.462558743683805	bayes_pls_golite062009
sequence-specific DNA binding	0.327072171076297	bayes_pls_golite062009

3

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle