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Protein Overview: daf-12

General Information:
Name(s) found: daf-12 / CE27586 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00000908 locus:daf-12 status:Confirmed UniProt:G5EBZ6 protein_id:CAC42285.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 267 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: negative regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed article]
    regulation of development, heterochronic [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPTHGFQYQ SDPYQVPPAE RNINYQLNAA ELKALDAVRE AFYGMDDPME QGRQMQSFLK  60
   61 ANKTPADIMN IMDVTMRRFV KVAKGVPAFR EVSQEGKFSL LKGGMIEMLT VRGVTRYDAS 120
  121 TNSFKTPTIK GQNVSVNVDD MFAKLNANAQ AQKAKCLEFF GFFDEEIKKN ELAVYLVMLA 180
  181 VLFSVRSDPP MNENDVRIVT ERHNHFMSLL NRYLESLFGE QARRIFERIP KALGLLNEIA 240
  241 RNAGMLFMGT VRSGEAEELP GEFFKIK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..267] PSI-BLAST 53.39794 LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.15996699473685 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.46162010671465 bayes_pls_golite062009
  • protein binding
    		•  0.33427459029264 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.15459949087509 bayes_pls_golite062009
  • DNA binding
    		•  0.14395376162921 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle