Protein Overview: ttb-1

General Information:
Name(s) found:	ttb-1 / CE27396 [WormBase]
Description(s) found: Found 20 descriptions. SHOW ALL	WBGene00006648 locus:ttb-1 Transcription initiation factor IIB status:Confirmed UniProt:O16991 protein_id:CCD74279.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	306 amino acids
Gene Ontology:
Cellular Component:	transcription factor complex [IEA]
Biological Process:	embryonic development ending in birth or egg hatching [IMP] regulation of transcription, DNA-dependent [IEA] transcription initiation [IEA] regulation of transcription [IEA]
Molecular Function:	zinc ion binding [IEA] transcription regulator activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAPVQCPIH PDVHLIEDHR AGDLVCPACG LVVGDRLVDV GTEWRSFSNE RSGNDPSRVG  60
   61 APENPLLSGG DLSTTIAVGF GGSDSDNSLA NAQRKSMNNT DRQMTAAMSL IREMSERIHL 120
  121 PRNIQDSASR IFKDVLESKA LRGKNNEAQA AACLYIACRK DGVPRTFKEI CAVSRVSKKE 180
  181 IGRCFKIIVR SLETNLEQIT SADFMSRFCG NLSLPNSIQA AATRIAKCAV DMDLVAGRTP 240
  241 ISIAAAAIYM ASQASAEKRS AKEIGDVAGA AEITVRQTYK LLYPKALELF PKDFRFVTPI 300
  301 DALPNS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..70]	FFAS03	3.1	RDC-derived models of the zinc ribbon domain of human general transcription TFIIB (zinc bound structures)
2	View Details	[71..306]	PSI-BLAST	39.69897	Transcription factor IIB (TFIIB), core domain

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	5.56373197054355	bayes_pls_golite062009
transcription elongation regulator activity	4.94644536450092	bayes_pls_golite062009
DNA-directed RNA polymerase activity	4.00205139503916	bayes_pls_golite062009
RNA polymerase activity	4.00205139503916	bayes_pls_golite062009
transcription regulator activity	3.26689775782701	bayes_pls_golite062009
nucleic acid binding	2.22680674586367	bayes_pls_golite062009
binding	2.0546846758949	bayes_pls_golite062009
DNA binding	2.01468878668039	bayes_pls_golite062009
positive transcription elongation factor activity	1.49227692053981	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.48570514124545	bayes_pls_golite062009
nucleotidyltransferase activity	1.10975425818967	bayes_pls_golite062009
protein binding	0.549662583711205	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.536637459961958	bayes_pls_golite062009
DNA primase activity	0.494157804587957	bayes_pls_golite062009
catalytic activity	0.433059249914853	bayes_pls_golite062009
RNA polymerase II transcription elongation factor activity	0.0384907163875292	bayes_pls_golite062009

2

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	6.34389570239956	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	3.19553060844126	bayes_pls_golite062009
protein kinase regulator activity	2.87088741581791	bayes_pls_golite062009
transcription regulator activity	2.795846725429	bayes_pls_golite062009
binding	2.4204867358489	bayes_pls_golite062009
nucleic acid binding	2.04886889839181	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.00665312545368	bayes_pls_golite062009
DNA binding	1.94297811210385	bayes_pls_golite062009
transcription elongation regulator activity	1.69439693414478	bayes_pls_golite062009
kinase regulator activity	1.65109787211976	bayes_pls_golite062009
protein binding	1.47106731485576	bayes_pls_golite062009
transcription factor activity	1.21921365719206	bayes_pls_golite062009
transcription factor binding	0.749278791251235	bayes_pls_golite062009
enzyme regulator activity	0.729629809946521	bayes_pls_golite062009
positive transcription elongation factor activity	0.42590121577004	bayes_pls_golite062009
transcription coactivator activity	0.138191616709499	bayes_pls_golite062009
transcription activator activity	0.0696060248241566	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle