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Protein Overview: hcf-1

General Information:
Name(s) found: hcf-1 / CE26914 [WormBase]
Description(s) found:
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  • WBGene00001827 locus:hcf-1 status:Confirmed UniProt:G5EC23 protein_id:CCD66593.1 [WormBase]
  • gi|3851534|gb|AAD12580.1| host cell factor 1 [Caenorhabditis elegans] [NCBI NR]
  • gi|17539228|ref|NP_501279.1| human HCF1 related family member (hcf-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|14550352|gb|AAB03147.2| Human hcf1 related protein 1, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • pir||T43277 host cell factor 1 - Caenorhabditis elegans [NCBI NR]
  • [wormpep67.fasta]
  • CE26914 WBGene00001827 locus:hcf-1 status:Confirmed TR:Q18654 protein_id:AAB03147.2 [wormpep150.fasta]
  • 26914 WBGene00001827 locus:hcf-1 status:Confirmed TR:Q18654 protein_id:AAB03147.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • human HCF1 related (87.4 kD) (hcf-1) [Caenorhabditis elegans]gi|14550352|gb|AAB03147.2| Human hcf1 related protein 1 [Caenorhabditis elegans]gi|3851534|gb|AAD12580.1| host cell factor 1 [Caenorhabditis elegans]gi|11359757|pir||T43277 host cell factor 1 [nrdb_11152004_Chlamydomonas]
  • locus:hcf-1 status:Confirmed TR:Q18654 protein_id:AAB03147.2 [wormpep115.fasta.reversed]
  • CE26914 locus:hcf-1 status:Confirmed [wormpep80.hongbin]
  • CE26914 WBGene00001827 locus:hcf-1 status:Confirmed UniProt:Q18654_CAEEL protein_id:AAB03147.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE26914 WBGene00001827 locus:hcf-1 status:Confirmed UniProt:Q18654_CAEEL protein_id:AAB03147.2| [wormORF-contam.fasta]
  • human HCF1 related family member (hcf-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Human hcf1 related protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • host cell factor 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE26914 WBGene00001827 locus:hcf-1 status:Confirmed UniProt:Q18654 protein_id:AAB03147.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE26914 WBGene00001827 locus:hcf-1 status:Confirmed UniProt:G5EC23 protein_id:CCD66593.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • HCF1 related OS=Caenorhabditis elegans GN=hcf-1 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 782 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: response to oxidative stress [IMP]
    determination of adult lifespan [IGI][IMP]
    dauer exit [IGI]
    response to metal ion [IMP]
    negative regulation of transcription by transcription factor localization [IMP]
    Molecular Function: protein binding [IEALink to PubMed article]
    transcription factor binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEDVGLEAT NYSRGDESRS EEQEKNVVRW RIVQQSTGPN PKPRHGHRAV VLKELIVIFG  60
   61 GGNEGMIDEL HAYNTQKREW TAPQCCGDVP TPAAAFGAIS LGNKIYRFGG MTEYGKYTND 120
  121 LYELQSTRWE WRRLNPRVHS NGHLPCPRIG HSFVVSQKSQ KAYVFGGLSN DLNDPKRNVP 180
  181 HYLDDLYVIN LSGPQHLIWE KLNATGPGPI SRESHTAVIY EKDSISRMVV YGGMNGVRLG 240
  241 DLWYLNLNTL HWTEIKFDDP RTGIPPMPRS LHSSVLIGDK MFVYGGWVPL LEHASTEQQT 300
  301 EKEWKCTSSL GCWNITEDRW VPLHLYCSDE DTIPRGRAGH CAAAVGDRMY IWSGRDGYRK 360
  361 AWSNQVCCRD MWLLDTILPE QPGKVQLGRA GFNSLEISWP IVQGASGYFL QIGFGDAKEQ 420
  421 SVSPIKRATT SPRKQPSIVP PSQKETEQSP KKPQGTAPSI ISTQGTTYTA PADPKPATDE 480
  481 GGLPQDLFED TEKNETASPK RSNDAQSADS STCEQKKTDE SGLEEDSEKD QKPSDAGETD 540
  541 EMKEENGDDD LPWFDVGIID KATINVTHYF NDRQQSLEKQ LNDLIDHNAF KCVNDSVFTT 600
  601 EDKIPLINGQ SYRFRVSAIN GLGKGAWSET ASCKTCVPGY PSAPSSIRIT KSHEGAQLTW 660
  661 EPPSNTNISG KIIEYSVYLA VKNQSANSAD SQLAFMRVYC GPQADCQVLQ SNLGTAFVDQ 720
  721 TNKPAIIFRI AARNEKGYGP ATQVRWLQDQ QKIPVRTNYP NNSGFIYQQH GGQQKRARFD 780
  781 HQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..378] PSI-BLAST 41.522879 1.35 angstrom structure of the Kelch domain of Keap1
    2 View Details [379..638] FFAS03 2.33 No description for 2ibgA was found.
    3 View Details [639..782] PSI-BLAST 16.0 Solution structure of C-terminal fibronectin type III domain of mouse 1700129L13Rik protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • receptor activity
    		•  2.70893613307252 bayes_pls_golite062009
  • binding
    		•  2.6879427326284 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.63145351876028 bayes_pls_golite062009
  • protein binding
    		•  2.21770026586875 bayes_pls_golite062009
  • cytokine binding
    		•  1.90627686584923 bayes_pls_golite062009
  • signal transducer activity
    		•  1.54896140065204 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.54896140065204 bayes_pls_golite062009
  • cytokine receptor activity
    		•  1.32127809692757 bayes_pls_golite062009
  • growth factor binding
    		•  1.07003653734093 bayes_pls_golite062009
  • receptor binding
    		•  0.44321055668528 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0111639672367196 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle